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Neprilysin gene transfer lowers Aβ and rescues behavior in Alzheimer models
A study in BMC Neuroscience demonstrated that neprilysin gene transfer reduces amyloid‑β (Aβ) burden and improves behavioral outcomes in animal models of Alzheimer’s disease. Researchers used...
Menin inhibitors: targeted strike on KMT2A leukemia
Researchers and clinicians are intensifying efforts to develop menin inhibitors as a targeted therapy for KMT2A‑rearranged acute leukemia. The development addresses a genetically defined,...
FDA biosimilar push stalls at patent office — regulatory tug‑of‑war
The FDA announced plans to streamline biosimilar approvals to mirror generic drug pathways, aiming to cut time and cost for biosimilar developers. Industry executives said the policy could reduce...
Jumbo phage attacks MBL Pseudomonas — a new MDR weapon
Researchers led by Paranos and colleagues report a jumbo bacteriophage with activity against metallo‑β‑lactamase (MBL)‑producing Pseudomonas aeruginosa, a pathogen frequently resistant to...
ACE2 decoy receptor neutralizes SARS‑CoV‑2 variants
Lin and collaborators developed an engineered ACE2 decoy receptor that neutralizes multiple SARS‑CoV‑2 variants, including mutant strains with altered spike proteins. The decoy binds viral spike...
CRISPR assay detects BK and JC viruses after kidney transplant
A CRISPR‑based diagnostic developed by Liu, Xu and Cao detects BK virus and JC virus in post‑kidney transplant patients, offering a rapid molecular tool for monitoring viral reactivation in...
mTORC1 in ILC2s: a neuro‑immune switch for allergic lung disease
Wang, Hu, Chen and colleagues reported in Nature Communications that mTORC1 signaling within group 2 innate lymphoid cells (ILC2s) mediates neuro‑immune communication driving allergic lung...
Sepsis: ferroptosis mechanism and IgG as prognostic biomarker
Two independent studies converge on actionable sepsis biology. First, researchers delineated ferroptosis — an iron‑dependent form of regulated cell death — as a contributing mechanism in sepsis...
T‑cell receptor therapy stalls in ovarian cancer — hurdles persist
Investigators surveying the state of T‑cell receptor (TCR) therapy for ovarian cancer report persistent translational challenges despite promising biology. Obstacles include antigen heterogeneity...
Wearables flag preflare physiology in rheumatoid arthritis
A multi‑institutional study finds that wearable sensors can detect physiological changes that precede symptomatic inflammatory and symptomatic flares in rheumatoid arthritis patients. The devices...
Fucosidase is required for rotavirus and norovirus replication
Parsons and co‑authors demonstrate that rotavirus and norovirus replication depends on host fucosidase activity required for processing fucose‑containing glycans used by these viruses during...
FDA plan to speed biosimilars: patent office tightening could stall rollout
The FDA announced a proposal to streamline biosimilar regulation to mirror generic drug pathways, aiming to cut development time and cost for copycat biologics. Industry leaders including Stefan...
ACE2 decoy receptor... neutralizes mutant SARS‑CoV‑2 variants
Researchers led by Lin et al. designed an ACE2 decoy receptor that neutralizes multiple SARS‑CoV‑2 variants, demonstrating activity against mutant spike proteins in preclinical assays. Published...
Single 2‑ml mirikizumab injection matches two 1‑ml doses — administration simplified
A pharmacokinetic study led by Otani, Payne and Loftus demonstrated that a single 2‑ml subcutaneous injection of mirikizumab is bioequivalent to two 1‑ml injections in healthy participants. The...
Sibiriline halts two cell‑death programs — a dual inhibitor emerges
Scientists reported a novel small molecule, Sibiriline, that simultaneously inhibits necroptosis and ferroptosis in preclinical models. The study describes Sibiriline’s biochemical activity...
mTORC1 in ILC2s links nerves to allergic lung inflammation
Wang, Hu, Chen and colleagues published a Nature Communications paper demonstrating that mTORC1 signaling in group 2 innate lymphoid cells (ILC2s) couples neuro‑immune inputs to allergic lung...
Plasma LPS levels forecast mortality in acutely ill children
A multicenter study in low‑ and middle‑income countries found that plasma lipopolysaccharide (LPS) concentrations strongly predict mortality among acutely ill children. Researchers measured...
CRISPR assay flags BK and JC viruses after kidney transplant
Liu, Xu, Cao and team developed a CRISPR‑based diagnostic that detects BK and JC polyomaviruses in post‑kidney transplant patients. The assay combines sequence‑specific CRISPR detection with rapid...
Genetic evidence ties gut microbiota to human bone mass
A 2025 Nature Communications study used human genetic analyses to link gut microbiota composition with bone mass regulation. The authors leveraged population genetics and host‑microbe association...
Ferroptosis implicated in sepsis and gastric cancer — targets multiply
Two independent studies highlighted ferroptosis as a central mechanism in both sepsis pathogenesis and gastric cancer therapy resistance. One paper describes how ferroptotic cell death pathways...