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Parkinson’s Disease Research Yields Insights on Protein Aggregates and Therapies
New studies illuminate molecular mechanisms central to Parkinson’s disease (PD). Investigations reveal that parkin-deficient human dopaminergic neurons derived from iPSCs generate α-synuclein...
Gilead’s HIV Prevention Injection Yeztugo Approved—A Biannual PrEP Milestone
Gilead Sciences attained FDA approval for Yeztugo (lenacapavir), the first twice-yearly injectable pre-exposure prophylaxis (PrEP) drug for HIV prevention. Clinical trials demonstrated up to 100%...
Breakthroughs in Neuroblastoma Therapy Using Human Amniotic Membrane Extracts
A pioneering study demonstrates that extracts from the human amniotic membrane (hAME) significantly potentiate the anti-cancer efficacy of doxorubicin in neuroblastoma cells by impeding...
Novel In Vivo CAR T Cell Generation via Targeted Lipid Nanoparticles
A transformative immunotherapy approach enables in vivo generation of chimeric antigen receptor (CAR) T cells directly within patients using antibody-conjugated lipid nanoparticles (tLNPs). These...
Cerium–Carbon Triple Bond Confined in Fullerene Cage
Researchers have achieved a landmark synthesis of a cerium–carbon triple bond encapsulated inside an endohedral fullerene, specifically a Ce≡CSc2 cluster within a C80 carbon cage. This work,...
FDA Review and Regulatory Innovations
The U.S. Food and Drug Administration (FDA) has initiated a pilot program led by Commissioner Martin Makary aimed at streamlining and accelerating the drug review process for medicines addressing...
Transformative Advances in Alzheimer’s Disease and Neurodegeneration
Recent discoveries have provided new insights into molecular mechanisms underlying Alzheimer's and Parkinson's diseases. Researchers have elucidated the pivotal role of α2,6-sialylation in...
Innovations in Cancer Therapies and Resistance Prediction
Significant progress is underway in cancer research focusing on acute leukemias, colorectal cancer, and drug resistance mechanisms. A novel therapeutic target combining histone acetyltransferases...
AI and Computational Advances in Biotech and Medicine
Emerging artificial intelligence (AI) and computational frameworks are revolutionizing biotechnological research and healthcare. At the 2025 BIO International Convention, novel AI-driven drug...
Pediatric and Neonatal Health Breakthroughs
Pediatric and neonatal care is witnessing critical advancements addressing infectious diseases, developmental challenges, and therapeutic monitoring. Studies in neonatal intensive care units have...
Advanced Drug Delivery and Pharmaceutical Technologies
The pharmaceutical field is seeing remarkable progress in drug delivery and synthesis methodologies. A novel nanoparticle system combining PLGA polymer with albumin exhibits ultrahigh colloidal...
Microbiome and Environmental Health Insights
Cutting-edge research links microbiome composition and environmental chemical monitoring to health outcomes. Studies reveal gut microbiota's influence on cardiac health in breast cancer patients,...
Structural and Functional Molecular Biology Breakthroughs
Molecular biology is advancing with discoveries in protein transport, chromosomal stability, and neural development. Key findings include transit peptides that enhance plastid protein import...
Regeneron Launches Major Proteomics Project With Geisinger Cohort
Regeneron's Genetics Center has initiated a large-scale proteomics study analyzing 200,000 blood samples from the Geisinger Health Study to enhance understanding of complex diseases and accelerate...
FDA Expands Indications for Dupixent and Monjuvi, Novartis Launches Mariana Oncology
The U.S. Food and Drug Administration has approved label expansions for Sanofi's Dupixent, extending its use to rare autoimmune conditions such as bullous pemphigoid, and Incyte's Monjuvi,...
Gene Solutions Partners With Chinese Firms to Commercialize Cancer Diagnostics
Gene Solutions has inked memoranda of understanding with two Chinese diagnostics companies, ZaoDx and MagicBiotech, to deploy its SPOT-MAS multi-cancer early detection test and next-generation...
Nanoparticle Drug Delivery System Enhances Stability and Loading Capacity
Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have developed a novel protein-polymer coassembly supraparticle by combining PLGA with human serum albumin, yielding...
Gilead’s Lenacapavir Approved as Twice-Yearly HIV Prevention Shot
The FDA has approved Gilead Sciences' lenacapavir (Yeztugo) for pre-exposure prophylaxis (PrEP) as the first twice-yearly injectable drug for HIV prevention. Clinical trials involving diverse...
Prothena Cuts Workforce After Amyloidosis Drug Failure
Prothena announced a major restructuring involving layoffs of approximately 63% of staff following the unsuccessful phase 3 trial of birtamimab, a monoclonal antibody aimed at treating advanced AL...
Neuroscience Study Identifies Thalamic Neurons Governing Sleep Recovery
Researchers at Johns Hopkins University have identified a subset of excitatory neurons in the thalamic nucleus reuniens (mRE) as key regulators of sleep homeostasis. Activation of these neurons in...