Get the Daily Brief
Latest Biotech News
Cutting-Edge Materials and Technologies for Biomedicine and Energy
Innovation at the intersection of material science and biotechnology progresses with new breakthroughs. Researchers created water-insensitive near-infrared down-shifting nanoparticles enhancing...
Biotech Funding and Industry Challenges Amid Regulatory and Market Dynamics
The biotech sector faces a challenging funding environment amid regulatory shifts and market uncertainties. Year-to-date capital raises for biopharma companies reveal mixed investment trends, and...
FDA Removes CAR T Therapy Risk Guardrails... Community Shift Accelerates
The FDA has eliminated Risk Evaluation and Mitigation Strategies (REMS) for six CAR T therapies targeting BCMA and CD19 antigens used in multiple myeloma and certain leukemias and lymphomas. This...
Dizal's Lung Cancer Pill Gains FDA Nod Ahead of PDUFA Date
Dizal Pharmaceutical's sunvozertinib (Zegfrovy) received accelerated approval from the FDA for treating adults with metastatic non-small-cell lung cancer harboring EGFR exon 20 insertion mutations...
CRISPR Erases Extra Chromosome in Down Syndrome Cells
Japanese researchers at Mie University have demonstrated the first use of CRISPR-Cas9 gene-editing technology to selectively remove the trisomy 21 chromosome responsible for Down syndrome in...
AI Model AlphaGenome Unifies Genome Variant Effect Predictions
Google DeepMind unveiled AlphaGenome, an AI foundation model that predicts the effects of genetic variants on multiple molecular genomic properties, including gene expression, splicing, and...
Engineering Gut Bacteria to Detoxify Toxic PFAS Chemicals
Scientists discovered that nine strains of human gut bacteria can effectively accumulate per- and polyfluoroalkyl substances (PFAS), notorious 'forever chemicals' with significant health risks....
Breakthrough Method Generates Lung Cells Without Stem Technology
Researchers in Japan have developed a novel technique to swiftly produce lung alveolar epithelial type 2-like cells from mouse embryonic fibroblasts without employing stem cell technologies. This...
FDA Approves Regeneron’s Multiple Myeloma Drug Lynozyfic
Regeneron Pharmaceuticals received FDA approval for Lynozyfic, a bispecific antibody for multiple myeloma treatment, distinguished by enhanced dosing flexibility over competitors from Johnson &...
Advances in Cancer Research Identify Molecular Drivers and Biomarkers
Multiple studies have revealed key molecular targets that drive cancer progression and may improve diagnostics. Insights include: the role of S100A4 in liver cancer metastasis via NMIIa...
CAR T Cell Therapies Show Enhanced Tumor Penetration and Immune Modulation
Cutting-edge research focuses on improving the delivery and efficacy of CAR T cell immunotherapies in solid tumors. Breakthroughs include gene engineering methods to armor CAR T cells with...
Synthetic DNA Nanoparticles Accelerate Gene Therapy Screening
Dr. Divita Mathur’s team at Case Western Reserve University has pioneered synthetic DNA nanoparticles facilitating efficient intracellular delivery and gene editing, supported by a National...
CRISPR Erases Extra Chromosome in Down Syndrome Cells
Japanese scientists led by Dr. Ryotaro Hashizume at Mie University have successfully used CRISPR-Cas9 gene editing to remove the extra chromosome 21 responsible for Down syndrome in lab-grown...
Dizal’s Lung Cancer Drug Gains Accelerated FDA Approval
Dizal Pharmaceutical secured accelerated FDA approval four days ahead of schedule for sunvozertinib (Zegfrovy), targeting non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations...
Advances in CAR-T and Immunotherapy for Solid Tumors
Pioneering studies reveal advances in CAR-T therapies targeting solid tumors like glioblastoma and multiple myeloma. Milan’s San Raffaele-Telethon Institute developed engineered CAR-T cells with...
Groundbreaking Imaging and AI in Cancer Diagnostics
Advancements in imaging and AI-driven models are enhancing cancer diagnostics and treatment predictions. A novel CT radiomics model improves discrimination between liver tumor types prior to...
Novel Molecular Insights and Therapeutic Targets in Cancer
Recent studies illuminate new molecular mechanisms and targets across various cancer types. Research identifies EMP1 as a driver in pancreatic cancer progression, CYP26A1 enzyme linked to folate...
Climate Change and Its Biological and Health Impacts
Studies reveal early fingerprints of climate change and its wide-ranging effects on biology and health. Thought experiments using historical climate models determine when scientists could have...
Breakthroughs in Neuroscience and Neurogenesis
Groundbreaking neuroscience research provides new insights into brain plasticity and neurogenesis. A study reveals that human thalamocortical connections develop following a hierarchical cortical...
Innovations in Stem Cell and Regenerative Medicine
New techniques in stem cell alignment and progenitor cell biology advance regenerative medicine. Researchers engineered aligned stem cell sheets that significantly enhance protein secretion,...