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FDA greenlights gene therapy for respiratory papillomatosis: Precigen scores rapid full approval
The U.S. Food and Drug Administration granted a swift and full approval to Precigen Inc.'s gene therapy, Papzimeos (zopapogene imadenovec), targeting recurrent respiratory papillomatosis (RRP)....
Pfizer’s sickle cell candidate fails Phase 3 trial: Setback for Global Blood Therapeutics asset
Pfizer announced the failure of its Phase 3 trial for inclacumab, a sickle cell disease candidate acquired through its $5.4 billion deal for Global Blood Therapeutics. The investigational drug did...
Human embryo implantation captured live in 3D: Novel imaging reveals early developmental biomechanics
Researchers at the Institute for Bioengineering of Catalonia and Dexeus University Hospital achieved the first ever real-time three-dimensional imaging of human embryo implantation into a collagen...
T cell therapy reshapes immunotherapy: Treg cells enhance pro-inflammatory Th17 response via IL-2
New research led by Cheng, Nan, and Ji uncovers a paradoxical immunological mechanism wherein regulatory T cells (Tregs) boost the pro-inflammatory T helper 17 (Th17) cell population through an...
Nab-paclitaxel and cisplatin combo shows superiority over gemcitabine regimen in biliary tract cancer
A multicenter randomized phase II trial published in BMC Cancer revealed that nab-paclitaxel combined with cisplatin outperforms gemcitabine plus cisplatin as chemotherapy in patients with...
Cell therapy manufacturing scales up: Made Scientific's new GMP facility in Princeton boosts capacity
Made Scientific celebrated the opening of a new 60,000-square-foot GMP-compliant manufacturing facility and headquarters in Princeton, New Jersey, enhancing its capabilities in cell therapy...
Genomill Health advances targeted NGS sample prep with Bridge Capture for clinical oncology
Finnish biotech Genomill Health introduced Bridge Capture, a novel targeted next-generation sequencing sample preparation technique enabling simple, cost-effective, and automatable detection of...
AI accelerates RNA vaccine delivery design: MIT reveals breakthroughs in lipid nanoparticle optimization
Massachusetts Institute of Technology researchers employed artificial intelligence to revolutionize the design of lipid nanoparticles (LNPs), crucial delivery vehicles for RNA vaccines and...
Platelets assume novel roles beyond clotting: Emerging evidence of DNA surveillance and cancer detection
Recent scientific investigations have expanded the understanding of platelets, traditionally known for their role in blood clotting, revealing unexpected functions in DNA damage surveillance and...
Loneliness linked to depression in adolescent and young adult cancer survivors
A recent study published in BMC Cancer explores the psychological aftermath of cancer survivorship among adolescents and young adults (AYAs), highlighting loneliness as a significant contributor...
FDA Approves Precigen’s Gene Therapy for Rare Respiratory Disease
The U.S. FDA has granted full and expedited approval to Precigen Inc.’s gene therapy, Papzimeos (zopapogene imadenovec), targeting recurrent respiratory papillomatosis (RRP), a rare disease marked...
Pfizer’s Sickle Cell Drug Fails Phase 3 Trial
Pfizer’s sickle cell disease candidate, inclacumab, failed to meet primary endpoints in a pivotal Phase 3 clinical trial, signaling a setback for the company's portfolio in hematology. This...
AI and Generative Models Transform Drug Discovery
Researchers at MIT and collaborators have pioneered the application of generative artificial intelligence to design novel antibiotic molecules capable of targeting drug-resistant pathogens such as...
Breakthrough Imaging Captures Human Embryo Implantation in 3D
Scientists from the Institute for Bioengineering of Catalonia and Dexeus University Hospital have, for the first time ever, recorded human embryo implantation in real time and three-dimensional...
Strategies and Advances in Cancer Immunotherapy
New clinical trials and studies reveal advancements in cancer immunotherapy across multiple tumor types. A Phase II trial showed the combination of nab-paclitaxel and cisplatin outperforming...
Innovations in Neonatal and Pediatric Care
Promising advancements emerged in neonatal and pediatric healthcare. Airway Therapeutics announced an expanded multinational Phase III trial for zelpultide alfa, targeting bronchopulmonary...
Breakthroughs in Materials Science and Energy Storage
Recent innovations in materials science demonstrate significant potential for energy and manufacturing sectors. Researchers unveiled one-dimensional titanate nanotubes designed to enhance...
Regulatory and Funding Developments in Biotech and Healthcare
Notable regulatory and funding developments shape the biotech landscape. The reinstatement of the U.S. childhood vaccine safety task force aims to enhance vaccine monitoring amid controversial...
Emerging Discoveries in Immunology and Cellular Biology
Cutting-edge research deepens understanding of immune mechanisms and cellular dynamics. Studies reveal that genetically engineered regulatory T cells with chimeric antigen receptors can...
Advances in Diagnostic and Analytical Technologies
Innovations in diagnostic technologies enhance precision medicine and research capabilities. Bionano Genomics reported advancements in optical genome mapping software with AI-driven variant...