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Financing for respiratory antibody programs
Windward Bio raised $165M to fund late-stage work across respiratory programs, including a lead long-acting antibody in development for asthma and COPD. The financing also supports a second...
Moderna’s reported entry into hantavirus vaccination
Reports say Moderna has initiated earliest-stage work on a hantavirus vaccine, driving a sharp market reaction. Coverage tied the move to potential collaboration with the US Army Medical Research...
Regulatory scrutiny and enforcement on healthcare fraud
The US Department of Justice escalated healthcare fraud enforcement by standing up a new West Coast strike force targeting Arizona, Nevada and Northern California. DOJ said the effort will focus...
FDA leadership shake-up
A report says President Trump plans to fire FDA Commissioner Marty Makary, potentially ending his turbulent tenure marked by sharp policy disputes and unusual turnover. The Wall Street Journal...
Cell spatial transcriptomics platform launch
10x Genomics introduced Atera, a new in situ spatial biology platform designed to deliver whole-transcriptome spatial analysis with single-cell sensitivity at scale. The company debuted the system...
Precision immunology in psoriasis
Researchers reported that epidermal MHC-II drives recruitment of natural killer cells in psoriasis, triggering pyroptosis in keratinocytes and fueling disease pathology. The findings connect...
Metformin mechanism tied to gut mitochondrial metabolism
A Northwestern University-led preclinical study in mice found metformin’s glucose-lowering effects are driven primarily by gut cell biology rather than liver-centric mechanisms. In Nature...
AI risk prediction for chemoresistance in bladder cancer
Researchers used machine learning to predict chemoresistance in muscle-invasive bladder cancer, according to a study published in Experimental & Molecular Medicine. The approach integrates...
Biomarker engineering for cancer cachexia
Researchers unveiled a computational and protein-engineering strategy to design binders targeting GDF15 for cancer cachexia, described as a new route for diagnosis and potential intervention. The...
Cancer immunotherapy combo for cancer of unknown primary
A phase II trial reported promising results for a second-line combination in cancer of unknown primary: an anti-PD-1 immune checkpoint inhibitor plus nab-paclitaxel. The study was led by Zhang and...
Company financing for clinical programs
Windward Bio secured $165 million in financing to fund clinical trials for its respiratory antibody pipeline, including a lead long-acting program aimed at asthma, COPD and related indications....
Infectious disease vaccine R&D signals
Reports say Moderna has started early-stage work on a hantavirus vaccine, a move that immediately sparked investor interest given there is currently no approved vaccine for hantavirus disease....
New diagnostics and lab authorization moves
Caris Life Sciences submitted an application to the New York State Department of Health for CLEP authorization to run its Caris Assure blood-based genomic profiling test on specimens from New...
Biotech IPO and capital for immunology pipeline development
Odyssey Therapeutics completed its IPO and raised $304 million for its quest to develop immunology drugs, with ulcerative colitis named as the lead indication for an internally discovered pipeline...
Biopharma market infrastructure and financing tracking
A new update tracks Odyssey’s move to Nasdaq and situates the listing among broader biotech equity activity, including follow-ons by multiple clinical-stage companies. The report notes that...
Drug-candidate discovery platform execution
Researchers reported a phase II signal in cancer of unknown primary (CUP) using a second-line regimen that pairs an anti–PD-1 immune checkpoint inhibitor with nab-paclitaxel. The work, led by...
Cell-free DNA diagnostic technology
Researchers unveiled a technique that dissects cell-free DNA fragment-size patterns to detect tumor-linked nucleosomal alterations. The approach leverages “fragmentomics”—the relationship between...
Therapeutic R&D: cardio-metabolic biology insights with metformin
A Northwestern University-led study reported preclinical evidence that metformin’s glucose-lowering effects in mice are tied primarily to action in the gut rather than solely the liver. Published...
Regulatory and enforcement shifts affecting healthcare and digital health
The US Department of Justice announced a new “West Coast” healthcare fraud strike force covering Arizona, Nevada and Northern California, targeting rising risks tied to Medicaid, hospice, and...
Regulatory leadership uncertainty at the FDA
Multiple reports say President Donald Trump plans to fire FDA Commissioner Marty Makary, though the plan is not finalized. If executed, the move would end Makary’s tenure, which has included...