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FDA clears Diasorin four‑plex assay: LIAISON Nes becomes CLIA‑waived
The US Food and Drug Administration issued 510(k) clearance and a CLIA waiver for Diasorin’s four‑plex molecular assay for Flu A/B, RSV and SARS‑CoV‑2 to run on the company’s new LIAISON Nes...
Potent cross‑neutralizing antibodies discovered: Marburg and Ravn targeted
Researchers reported discovery of a new class of potent antibodies that neutralize both Marburg virus and the related Ravn virus, findings published in npj Viruses. The study characterizes...
CAR‑T vs bispecifics... meta‑analysis contrasts treatments in relapsed B‑cell NHL
A new meta‑analysis compared outcomes of CAR‑T cell therapy and bispecific antibody therapy in relapsed or refractory indolent B‑cell non‑Hodgkin’s lymphomas. The study aggregates efficacy and...
RNA‑guided STAT3 reprograms T‑cell fate in lung cancer
A team uncovered an RNA‑guided mechanism by which STAT3 signaling shapes CD4+ T helper cell fate in non‑small‑cell lung cancer (NSCLC), detailing coordinated epigenetic and epitranscriptomic...
HiSTaR maps tissue architecture: hierarchical spatial transcriptomics
Researchers Yu, J., Yuan, J., Yi, Q. and colleagues introduced HiSTaR, a hierarchical spatial transcriptomics variational autoencoder, to map spatial domains and cellular interactions in complex...
Conformal silicon Hall sensors... early 3‑D tumor monitoring
A team published a conformal, ultrathin crystalline‑silicon Hall sensor array designed for early monitoring of three‑dimensional tumor tissues. Presented in npj Flexible Electronics, the device...
AI spots hidden arrhythmia: paroxysmal AF detected from sinus‑rhythm ECGs
Researchers developed AI software that detects paroxysmal atrial fibrillation (PAF) from ECG recordings taken during sinus rhythm, addressing a major diagnostic blind spot. The model was trained...
Ovarian cancer mechanisms: DJ‑1 autophagy link and lncRNA m6A regulation
Two independent studies identified molecular drivers that promote ovarian cancer progression. One team showed that the oncogene DJ‑1 regulates autophagy through the JNK signaling pathway,...
Multi‑omics spatial map identifies lung repair niches in pediatric ARDS
A multi‑omics study led by Song, Liu, Bai and colleagues in the Journal of Translational Medicine profiled spatial compartments in pediatric acute respiratory distress syndrome (ARDS) to identify...
Maternal methylation signatures flag gestational diabetes across pregnancy
An interdisciplinary team reported DNA methylation signatures in maternal blood that associate with gestational diabetes at multiple pregnancy stages. The study tracked methylation changes...
FDA clears Diasorin four‑plex assay — molecular PCR goes point‑of‑care
The FDA issued a 510(k) clearance and a CLIA waiver for Diasorin’s four‑plex molecular assay on the Liaison Nes platform, enabling rapid differentiation of Flu A/B, RSV and SARS‑CoV‑2 at the point...
White House proposes 40% NIH cut: researchers brace for disruptions
A detailed retrospective traces the NIH’s origins and warns that widespread grant terminations in 2025 and a White House proposal to cut the NIH budget by 40% for 2026 threaten the agency’s...
New antibodies neutralize Marburg...and Ravn
Researchers reported in npj Viruses the discovery of potent cross‑neutralizing antibodies that can neutralize both Marburg virus and the closely related Ravn virus. The antibodies target conserved...
CAR‑T vs bispecific antibodies: meta‑analysis compares efficacy in relapsed B‑cell NHL
A new meta‑analysis aggregated clinical data comparing CAR‑T cell therapies and bispecific antibody treatments in relapsed or refractory indolent B‑cell non‑Hodgkin’s lymphoma. The study performs...
AI flags paroxysmal AF from sinus‑rhythm ECGs — new detection software
A research team developed AI software designed to detect paroxysmal atrial fibrillation (PAF) from ECG traces recorded during sinus rhythm, addressing a key diagnostic blind spot for intermittent...
Conformal silicon Hall sensors...catch 3D tumors early
A multidisciplinary team published a conformal, ultrathin crystalline‑silicon Hall sensor array that enables early‑stage monitoring of three‑dimensional tumor tissues. Reported in npj Flexible...
RNA‑guided STAT3 reprograms CD4+ T cells in NSCLC — immunotherapy angle
Researchers uncovered a mechanism by which RNA‑guided modulation of STAT3 influences CD4+ T helper cell fate in non‑small cell lung cancer, reshaping epigenetic and epitranscriptomic programs. The...
CGMs cut costs ~20% but 80% of eligible patients still don’t use them
A new analysis reported that continuous glucose monitors (CGMs) reduce overall healthcare costs by roughly 20% for insulin‑dependent diabetes patients—primarily by cutting hospitalizations and ED...
Multi‑omics maps lung repair niches in pediatric ARDS — distinct spatial compartments found
A multi‑omics spatial study in pediatric acute respiratory distress syndrome (ARDS) identified discrete lung compartments associated with tissue repair, providing a molecular atlas of cellular...
LncRNA CYTOR drives metastasis and drug resistance in triple‑negative breast cancer
Investigators reported that the long non‑coding RNA CYTOR modulates pathways linked to metastasis and chemoresistance in triple‑negative breast cancer (TNBC), revealing a potential molecular lever...