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Lilly, Innovent sign $8.8B oncology‑immunology pact – $350M upfront
Eli Lilly expanded its collaboration with China’s Innovent Biologics under a deal worth up to $8.8 billion, including $350 million in upfront payments to jointly develop oncology and immunology...
Aerska raises $39M — back‑to‑back financing to ferry siRNA past the blood‑brain barrier
Aerska Therapeutics, a startup developing 'brain shuttle' technology to deliver larger molecules across the blood‑brain barrier, raised $39 million in a follow‑on financing, the company told STAT....
Phage‑antibiotic combo defeats resistant peritonitis in study
Researchers reported in Nature Communications that combining bacteriophage therapy with traditional antibiotics cleared refractory Klebsiella pneumoniae peritonitis in a preclinical model of...
Cell and gene therapy supply chains: navigating scale, cold chain and identity
A sector briefing from Catalent and industry analysts highlighted the acute complexity of cell and gene therapy (CGT) supply chains—ranging from collection and chain‑of‑identity to manufacturing,...
Illegal biolab raid in Las Vegas: Israeli national arrested after 'deathly ill' exposures
Las Vegas police arrested an Israeli citizen following a raid on an alleged illicit biolab where multiple people reportedly became 'deathly ill.' Authorities seized more than 1,000 samples,...
OpenEvidence hits $12B valuation — clinician uptake and ad model draw scrutiny
OpenEvidence reached a reported $12 billion valuation as investors rewarded rapid clinician adoption of its AI medical search tool, which the company says is used regularly by more than 430,000...
Lilly plunks down $350M: Expands Innovent tie on cancer and immune drugs
Eli Lilly agreed to expand its collaboration with Innovent Biologics via a new deal that includes a $350 million upfront payment to develop oncology and immunology programs. The agreement—reported...
Hims halts GLP‑1 rollouts... regulators and rivals push back
Telehealth firm Hims & Hers said it will stop offering a compounded version of Novo Nordisk’s Wegovy following legal pressure from regulators and industry challengers. The company faced federal...
Roivant’s brepocitinib clears proof‑of‑concept: Pivotal testing next
Roivant Sciences’ subsidiary Priovant Therapeutics reported that brepocitinib, a dual JAK1/TYK2 inhibitor licensed from Pfizer, met the goals of a proof‑of‑concept study in cutaneous sarcoidosis....
Sanofi unpacks failed tolebrutinib Phase 3 – retreat from PPMS
Sanofi presented data from a failed Phase 3 trial of the BTK inhibitor tolebrutinib in primary progressive multiple sclerosis (PPMS), explaining the company’s decision to withdraw from that...
Las Vegas biolab raid: FBI seizes samples after residents fall "deathly ill"
Las Vegas police arrested an Israeli national and seized more than 1,000 samples and laboratory equipment from a residential property after several people reported becoming “deathly ill,”...
Phage plus antibiotic defeats resistant Klebsiella peritonitis – study
Researchers published a Nature Communications study showing a combination of bacteriophages and antibiotics effectively treated refractory peritoneal dialysis‑related peritonitis caused by...
Metabolism drives fungal invasion: CCMB identifies therapeutic levers
Researchers at the Centre for Cellular and Molecular Biology (CCMB) reported that metabolic pathways underlie fungal invasion and influence responses to antifungal therapy. The team identified...
Triple blockade ignites CXCL16–CXCR6 tumor immunity – STING, TGF‑β, PD‑L1 targeted
A research team reported that simultaneous modulation of STING, TGF‑β, and PD‑L1 pathways markedly enhanced antitumor responses via the CXCL16–CXCR6 signaling axis. The triple‑targeting approach...
Inflammasome protein ASC rewires pancreatic cancer metabolism – Nature Communications
A Nature Communications study led by Chey, Kashgari, and McLeod identified the inflammasome‑associated protein ASC as a central regulator connecting innate immune signaling to mitochondrial...
3D gut‑brain‑vascular model maps bidirectional disease mechanisms
Researchers published a Nature Communications report introducing a 3D gut‑brain‑vascular platform that models communication among the gut, brain, and vasculature. The system reproduces key...
Brepocitinib proof-of-concept clears cutaneous sarcoidosis – Roivant advances to pivotal
Roivant subsidiary Priovant reported that brepocitinib, a dual JAK1/TYK2 inhibitor licensed from Pfizer, met the primary goals of a proof-of-concept study in cutaneous sarcoidosis. The trial...
Sanofi data drop: tolebrutinib misses primary in PPMS – program retreats
Sanofi disclosed data from a failed Phase 3 trial of the BTK inhibitor tolebrutinib in primary progressive multiple sclerosis (PPMS), prompting the company to retreat from that indication. The...
Phage plus antibiotic defeats MDR Klebsiella peritonitis – new combo therapy shown
Researchers published a Nature Communications study showing a bacteriophage–antibiotic combination cured refractory peritoneal dialysis–related peritonitis caused by multidrug-resistant Klebsiella...
ASC inflammasome links immune sensing to metabolism in pancreatic cancer
A Nature Communications paper by Chey, Kashgari, McLeod and colleagues identified the inflammasome-associated protein ASC as a central regulator connecting innate immune signaling to mitochondrial...