Latest Biotech News

Japan regulators approved AmoyDx’s lung cancer test as a companion diagnostic for Hernexeos, extending the tool’s use in HER2-positive non-small cell lung cancer. The approval positions Hernexeos...

AstraZeneca ended a Phase 3 volrustomig trial after failing to show benefit versus an existing standard in lung cancer, marking another retreat in its late-stage oncology pipeline. The decision...

Argenx reported a Phase 3 win for Vyvgart Hytrulo in autoimmune myositis, but the company said the drug missed the mark in a key patient subgroup. The subcutaneous therapy is intended for a rare...

Evaxion scrapped its next-gen solid tumor vaccine program EVX-03 and redirected resources toward a Duke-partnered brain cancer candidate, tightening focus after EVX-03 failed to progress into...

Cretostimogene grenadenorepvec produced complete responses in three-quarters of patients with high-risk, BCG-unresponsive non–muscle-invasive bladder cancer with carcinoma in situ in a Phase 3...

Researchers identified new Plasmodium falciparum genetic variants linked to decreased susceptibility to antimalarial drugs after sequencing parasites collected from infected people in Uganda. The...

A critique published in the Journal of Perinatology raises concerns about how nutritional confounding and reporting gaps limited conclusions from the JASMINE trial. B.C. King and co-authors...

Researchers reported virus-like particles that enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, a step toward higher-throughput functional genomics in...

A new industry perspective argues that healthcare organizations are deploying AI tools but are not yet prepared to manage AI agents inside everyday clinical workflows. The article frames the gap...

Two preclinical studies add mechanistic detail to how tumors survive therapy and how ferroptosis pathways can be modulated. One study links VRK2 to gemcitabine resistance in pancreatic cancer...

AstraZeneca has halted its phase 3 lung cancer trial of volrustomig (a bispecific combination strategy) after interim data showed it was unlikely to improve survival versus pembrolizumab...

AstraZeneca revealed it has stopped another phase 3 lung cancer trial in the same period, citing interim findings that its volrustomig program, when combined with chemotherapy, was unlikely to...

Cretostimogene grenadenorepvec (a BCG-unresponsive intravesical oncolytic immunotherapy) produced complete responses in three-quarters of patients in the phase III BOND-003 cohort C trial for...

Fujifilm Biotechnologies has highlighted progress at its Holly Springs, North Carolina manufacturing footprint as part of broader capacity buildouts for cell culture drug substance and product....

Researchers reported that virus-like particles can enable efficient targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, with the work published in Nature...

A study published on long-term GLP-1 exposure describes how pancreatic beta cells undergo a reprogramming-like shift in gene expression through phosphorylation of a key protein, according to the...

Researchers in npj Parkinson’s Disease reported that a peripheral diagnostic panel can help decode clinical masking in SAA-positive Parkinson’s disease, aiming to address diagnostic ambiguity even...

A preclinical study in Cell Death Discovery reports that blocking PHGDH can overcome dabrafenib resistance through metabolic rewiring in BRAF V600E anaplastic thyroid carcinoma models. The work,...

Whole-genome sequencing of Plasmodium falciparum from hundreds of infected people in Uganda has identified a rapidly spreading cluster of polymorphisms associated with decreased susceptibility to...

A new publicly available tumor organoid biobank has mapped clinically annotated cancer cell dependencies across 256 organoids, using whole-genome/transcriptome sequencing and genome-wide...