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AbbVie Expands In Vivo CAR-T Portfolio with Capstan Acquisition
AbbVie announced a $2.1 billion acquisition of Capstan Therapeutics, gaining rights to a phase 1-stage in vivo CAR-T therapy targeting CD19 and Capstan’s proprietary targeted lipid nanoparticle...
Moderna’s mRNA Flu Vaccine Achieves Phase 3 Superiority
Moderna reported positive Phase 3 data for its seasonal influenza vaccine mRNA-1010, demonstrating a 26.6% relative efficacy over a standard-dose comparator in adults 50 years and older across...
Genetic and Molecular Insights into Cancer and Neurological Disorders
Recent studies have uncovered key mechanisms impacting various cancers and neurodegenerative diseases. Groundbreaking research highlights the role of mutant p53 and SH3BGRL in cancer cell...
Advances in AI and Diagnostics in Healthcare
Innovations in artificial intelligence are reshaping diagnostics and therapy. A new AI-driven system from Kindai University enhances classification of facial pigmented lesions, while University of...
Continued Challenges and Setbacks in Drug Development Pipelines
Pharma companies face notable hurdles as INmune Bio’s Alzheimer’s disease program missed key Phase 2 endpoints despite subgroup benefits, and Pfizer terminated one of two CD47 drug trials from its...
Microbiome and Environmental Health Discoveries
New research reveals critical roles for microbiota and environmental factors in human and ecological health. A mouse study demonstrated that human gut bacteria can bioaccumulate “forever...
Innovations in Genetic Engineering and Genome Editing
Recent innovations in genome editing reveal transformative potential. Researchers introduced a near-infrared-activated chemically induced CRISPR system enabling precise spatiotemporal control of...
SGLT2 Inhibitors and Cancer Survival Insights
New clinical evidence expands indications for existing classes of drugs. A retrospective cohort study published in BMC Cancer suggests sodium-glucose cotransporter-2 inhibitors (SGLT2i), typically...
Market and Industry Developments in Biotech and Healthcare
The biotech sector reflects mixed trends: Sage Therapeutics plans massive layoffs following its acquisition by Supernus Pharmaceuticals amid pipeline challenges. Major venture capital disputes...
AbbVie’s $2.1B Bet on In Vivo CAR-T Platform Signals Immunotherapy Push
AbbVie has agreed to acquire Capstan Therapeutics in a deal valued up to $2.1 billion, advancing the pharma giant’s in vivo CAR-T therapy ambitions. Capstan’s technology enables direct engineering...
Moderna’s mRNA Flu Vaccine Surpasses Competitor in Large Phase 3 Trial
Moderna’s seasonal influenza vaccine candidate, mRNA-1010, demonstrated a 26.6% relative vaccine efficacy over a licensed standard-dose seasonal influenza vaccine in adults aged 50 and older...
Sage Therapeutics to Slash Workforce After Supernus Acquisition
Sage Therapeutics, soon to be acquired by Supernus Pharmaceuticals, plans to lay off approximately 338 employees, representing the vast majority of its workforce. This decision follows Supernus’s...
AI Advances Early Detection and Prognosis in Pancreatic Cancer
Researchers at the University of Sharjah have developed novel artificial intelligence models capable of early-stage pancreatic cancer detection as well as disease prognosis prediction. Given...
Novel Gene Editing Control with Near-Infrared Activated CRISPR System
Researchers have engineered a chemically induced CRISPR system activated by near-infrared light, enabling precise spatiotemporal genome editing control. This platform expands upon the specificity...
Breakthrough Study Links Gut Microbiota to Miscarriage Risk in PCOS
At the 41st Annual Meeting of the European Society of Human Reproduction and Embryology, investigators revealed associations between altered gut microbiota and amino acid metabolism with increased...
Thermo Fisher-Tufts Study Shows CRO-CDMO Integration Cuts Cancer Drug Timelines
A white paper by Tufts Center for the Study of Drug Development, commissioned by Thermo Fisher Scientific, highlights that integrated contract development and manufacturing organization (CDMO) and...
Groundbreaking Luminescent Sensor Developed for Early Liver Cancer Detection
Scientists at the Indian Institute of Science have introduced a terbium-based paper sensor that exhibits high sensitivity for detecting the liver cancer biomarker β-glucuronidase. The novel...
Alzheimer’s Research Investment Surges After New Monoclonal Antibody Approvals
Following the FDA approvals of monoclonal antibodies Leqembi and Kisunla, investment and M&A deals in Alzheimer’s research soared by 780% from $2 billion in 2022 to $18 billion in 2024, according...
Breakthrough Links Genetic Ancestry to Dengue Severity via Skin Immune Responses
A collaborative study from the University of Pittsburgh and Brazilian institutes has for the first time demonstrated that genetic ancestry significantly influences inflammatory responses in human...
Moderna’s mRNA Flu Vaccine Beats Competitor in Phase 3 Trial
Moderna has reported positive phase 3 clinical trial results for its seasonal influenza vaccine mRNA-1010, demonstrating a 26.6% relative vaccine efficacy over a licensed standard-dose vaccine in...