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Roche’s Astegolimab Fails Phase 3 in COPD, Delaying Approval Prospects
Roche announced its anti-ST2 monoclonal antibody astegolimab failed to reduce flare-ups in a pivotal Phase 3 study for chronic obstructive pulmonary disease (COPD). The setback significantly dims...
Cloudbreak Pharma Eyes Phase 3 After Positive Phase 2 Eye Drop Trial
Cloudbreak Pharma achieved its primary endpoint in Phase 2 for eye disease candidate CBT-004, an eye drop formulation. Encouraged by this mid-stage success, the company plans to advance CBT-004...
Seegene’s CURECA System: Toward Fully Unattended PCR Automation
Seegene is developing CURECA, the world’s first fully unattended PCR automation platform designed for continuous, 24/7 operation without human intervention. Addressing critical workflow gaps like...
Click Chemistry Used Safely in Humans to Target Tumors
Researchers have applied click chemistry, a Nobel Prize-winning technique, for the first time in human cancer patients to selectively deliver chemotherapy directly to tumors. This approach...
Phylogenetic Approach Uncovers Regulatory Roles of Transposons in Primate Genomes
A new study published in Science Advances by Kyoto University and McGill University researchers used phylogenetic analysis and cross-species conservation to annotate transposable element...
Hookipa Pharma to Liquidate After Asset Sales and Merger Collapse
Hookipa Pharma announced plans to delist from Nasdaq and fully liquidate following the sale of its key vaccine assets to Gilead and the cancellation of a merger with Poolbeg Pharma. With no...
Sarepta Shares Dive Post Patient Death in LGMD Gene Therapy Trial
Sarepta Therapeutics’ shares plummeted 36% after a third patient treated with its LGMD gene therapy SRP-9004 died from acute liver failure in a Phase 1 trial. This follows two earlier patient...
Seegene Launches CURECA: Fully Automated PCR System
Seegene is pioneering an end-to-end PCR automation platform named CURECA intended to revolutionize molecular diagnostics workflows. Unlike conventional automation that addresses isolated steps,...
Sarepta Gene Therapy Death Spurs Investor Selloff
Sarepta Therapeutics experienced a 36% stock drop after disclosure of a third patient death linked to its gene therapies this year. The latest fatality involved a 51-year-old treated with SRP-9004...
Engineered E. coli Produces Milk Proteins for Vegan Dairy
Scientists have genetically modified E. coli bacteria to synthesize key proteins found in milk, creating potential for producing vegan cheese and yogurt without animal-derived ingredients. This...
Novel Click Chemistry Used Safely for Cancer Treatment in Humans
Researchers have successfully applied Nobel Prize-winning click chemistry technology for the first time in humans, enabling targeted delivery of chemotherapy drugs directly to tumors. This method...
PathoPlex Multiplexing Transforms Kidney Disease Mapping
A new high-dimensional multiplexing technology named PathoPlex offers unprecedented insight into immune-mediated kidney diseases by allowing spatially resolved cellular and molecular mapping. This...
Single-Cell Atlas Reveals Chemokine Links in Type 2 Diabetes
A groundbreaking single-cell study has unveiled crucial immunological disruptions in type 2 diabetes, linking specific chemokines to disease progression. By dissecting immune cell populations and...
Xeltis Reports Positive EU Clinical Data for Coronary Bypass Conduit
Xeltis has announced encouraging results from a European clinical trial evaluating Xabg, an artificial coronary artery bypass conduit that gradually transitions to living tissue through...
Solid Oxide Cells Advance with Monolithic Gyroidal 3D Printing
Researchers have introduced a novel 3D-printed monolithic gyroidal design for solid oxide cells, significantly enhancing their efficiency, durability, and structural integration. Moving beyond...
Machine Learning Deciphers Sorghum Mold Resistance Genetics
Applying machine learning techniques, scientists have unraveled the complex genetic basis for mold resistance in sorghum, a key cereal crop. This approach accelerates identification of resistance...
FDA Approval Process Under Scrutiny Amid Mifepristone Report Debate
A recent report challenging the FDA's approval of mifepristone has ignited controversy, though the medication remains one of the most extensively reviewed and safely used drugs over 25 years....
Sarepta Gene Therapy Deaths Spike: Stock Tumbles 36%
Sarepta Therapeutics faces a crisis after the death of a third patient linked to its gene therapies this year. The latest fatality involved a 51-year-old man with limb girdle muscular dystrophy...
Gene Therapy Safety Crisis Sparks Industry Reckoning
The recent fatalities linked to Sarepta’s gene therapies evoke parallels with the historic Jesse Gelsinger case, reigniting scrutiny of safety in AAV-mediated treatments. Industry experts and FDA...
Patient Voices Urge Duchenne Therapeutics Progress Despite Risks
Mothers of Duchenne muscular dystrophy patients provide poignant testimony amid escalating fatalities linked to gene therapies. They underscore the harsh realities faced by families confronting a...