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Breakthrough Molecular Insights Reshape Leukemia Treatment Strategies
A study published in Nature Cancer has revealed that the developmental stage of B cells at leukemia onset critically affects therapy response in pediatric B-cell acute lymphoblastic leukemia...
Vetter Invests $285M in New Clinical Manufacturing Site in Illinois
German contract development and manufacturing organization Vetter has commenced construction of a 160,000-square-foot clinical manufacturing facility in Des Plaines, Illinois, marking a strategic...
UMass Chan Study Deciphers Molecular Basis of Ciliopathies
Researchers at UMass Chan Medical School have elucidated critical molecular mechanisms governing cilia development, shedding light on severe human ciliopathies caused by defects in the TMEM67...
ColdBrew Algorithm Enhances Drug Discovery via Water Dynamics Modeling
Scientists at St. Jude Children’s Research Hospital developed ColdBrew, an innovative computational algorithm that accurately models water molecule positioning in protein binding sites at...
Wholomics Advances Multi-Cancer Detection with Metabolomic Profiling
Startup Wholomics, originating from Dana Farber and University College London collaborations, has presented early data showcasing a novel metabolomic platform for multi-cancer detection in serum...
Neurological Insights Link SLC13A5 Mutations to Severe Epileptic Encephalopathy
Groundbreaking work from the CeMM Research Center has decoded how mutations in the SLC13A5 citrate transporter disrupt neuronal metabolism, causing developmental epileptic encephalopathy (DEE)....
Pesticide Impact on Gut Microbiome Revealed in High-Resolution Study
Researchers at The Ohio State University have published a detailed molecular atlas describing how widespread pesticides affect human gut bacterial species and their metabolism. Exposing...
New Urine-Based Tumor DNA Test Forecasts Bladder Cancer Recurrence
A multi-institutional study published in European Urology introduces a novel urine-based tumor DNA assay to predict recurrence risk in bladder cancer patients undergoing atezolizumab...
FDA Boosts CAR-T Therapy Access – Removes Safety Hurdles
The FDA has significantly eased regulatory constraints on CAR T-cell therapies used for blood cancers like leukemia and lymphoma. The agency eliminated the Risk Evaluation and Mitigation...
Calico Life Sciences Secures $571M Deal for Anti-aging Therapy
Alphabet’s Calico Life Sciences has inked a licensing deal worth up to $571 million with China-based Mabwell Bioscience to acquire exclusive global rights (excluding greater China) to 9MW3811, a...
Breakthrough in Breast Milk Production with Lab-Grown Tissue Model
Researchers at ETH Zurich have developed a volumetric bioprinting method to create 3D replicas of human lactating breast tissue, enabling in vitro study of milk synthesis. Using laser sculpting...
New Computational Tool Illuminates Water’s Role in Drug Discovery
Scientists at St. Jude Children’s Research Hospital introduced ColdBrew, a novel algorithm that predicts the behavior and placement of water molecules in protein binding sites at physiological...
Advances in Rare Disease Regulatory Policy and FDA Dynamics
Landmark upcoming FDA approval decisions will test the agency's commitment to biomarker-based accelerated approvals for orphan drugs, potentially reshaping rare disease regulatory frameworks....
Multicancer Detection Startup Wholomics Pursues Metabolomic Precision
Wholomics, founded by researchers from Dana Farber and University College London, presented new data demonstrating its serum-based metabolomic platform’s ability to detect multiple cancers at...
New Genetic ‘Dimmer Switch’ Regulates Embryonic Gene Expression
Researchers at the MRC London Institute of Medical Sciences identified a novel DNA attenuator element that precisely modulates the duration and strength of Cdx2 gene expression during early...
Severe Epilepsy Linked to SLC13A5 Citrate Transporter Mutations
A comprehensive functional and structural analysis led by Giulio Superti-Furga at CeMM uncovered how mutations in the citrate transporter SLC13A5 disrupt neuronal metabolism, causing a severe...
Novel Urine-Based DNA Test Enhances Bladder Cancer Immunotherapy
A multi-institutional study published in European Urology demonstrated that quantification of urine tumor DNA (utDNA) can accurately predict recurrence risk in patients with high-risk...
Vetter Launches $285M Clinical Manufacturing Facility in Illinois
German contract development and manufacturing organization Vetter initiated construction of a new 160,000-square-foot clinical production site in Des Plaines, Illinois, with an estimated...
FDA Unwinds Safety Barriers for CAR-T Therapies – Access Boosted
The FDA has removed previous safety monitoring requirements and loosened administration restrictions for approved CAR-T therapies, signaling a significant shift in regulatory policy to improve...
Alphabet’s Calico Locks in $596M Mabwell Deal for Age-Related Drug
Alphabet's Calico Life Sciences inked an exclusive licensing deal with Mabwell Bioscience for up to $596 million targeting interleukin-11 therapeutics. Calico gains global rights, excluding...