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Novel therapeutic discoveries inaugurate new options in oncology and autoimmune diseases
Emerging therapies showcase advances in difficult diseases. Cytokine-induced killer cell therapy improves survival in colorectal cancer patients versus standard treatments. Hybrid combination...
Gene Therapy Extends Survival in Neurodegenerative Disease Model
A research team demonstrated a novel gene therapy using adeno-associated virus (AAV) to deliver RNA interference targeting the ataxin-2 gene, significantly extending survival and mitigating...
FDA Investigates Safety of Duchenne Gene Therapy After Patient Deaths
The FDA is investigating deaths related to liver failure following administration of Sarepta Therapeutics’ gene therapy for Duchenne muscular dystrophy. The regulator is assessing whether further...
AI Advances Semiconductor Growth with Autonomous Molecular Beam Epitaxy
The Paul Drude Institute and Bizmuth MBE Ltd. unveiled a collaborative project integrating large language models and multimodal AI technologies to autonomously control molecular beam epitaxy (MBE)...
City of Hope Launches Generative AI Platform to Personalize Cancer Care
City of Hope developed HopeLLM, a generative AI platform leveraging extensive oncology data to streamline clinical workflows and enhance patient personalization. The platform automates new patient...
Revolution Medicines Secures $2 Billion Royalty Deal to Fuel RAS(ON) Inhibitor Development
Revolution Medicines (Revmed) closed a landmark $2 billion flexible funding agreement with Royalty Pharma to support late-stage development and commercialization of its RAS(ON) multi-selective...
Nektar Therapeutics' Rezpeg Shows Promise in Atopic Dermatitis Phase 2b Trial
Nektar Therapeutics announced successful Phase 2b results for rezpegaldesleukin (rezpeg), an IL-2 pathway agonist, in moderate to severe atopic dermatitis. The drug hit primary and secondary...
Cidara Therapeutics Advances Long-Lasting Antiviral Against Influenza
Cidara Therapeutics reported positive mid-stage data for CD388, a drug-Fc conjugate antiviral providing season-long prophylaxis against influenza A and B viruses. Phase 2b results showed that a...
Deep Learning Improves Prediction of Walking Forces with Knee Alignment Data
Researchers demonstrated that incorporating detailed knee alignment parameters into deep learning models significantly enhances the accuracy of predicting ground reaction forces during walking....
Mitochondrial Base Editing Corrects Pathogenic Mutations in Human Cells
A team led by the University Medical Center Utrecht successfully applied mitochondrial base editing (mtBE) using a DddA-derived cytosine base editor (DdCBE) to precisely correct deleterious...
Advanced AI Tool Dissects Tumor Cellular Heterogeneity to Guide Cancer Treatment
An international consortium including the Garvan Institute developed AAnet, an artificial neural network leveraging single-cell gene expression data to resolve the diverse cellular populations...
FDA Probes Sarepta Duchenne Gene Therapy After Patient Deaths
The FDA is investigating Sarepta Therapeutics' gene therapy for Duchenne muscular dystrophy following patient deaths linked to liver failure. This regulatory scrutiny highlights concerns over...
Revolution Medicine Secures $2 Billion for RAS(ON) Cancer Drug Development
Revolution Medicines closed a flexible funding agreement with Royalty Pharma for up to $2 billion to accelerate late-stage development and commercialization of its RAS(ON) inhibitors, including...
Nektar Therapeutics' Rezpegaldesleukin Shows Promise in Atopic Dermatitis Phase 2b Trial
Nektar Therapeutics reported positive Phase 2b results for rezpegaldesleukin in moderate to severe atopic dermatitis, achieving primary and secondary endpoints. The immunomodulatory biologic...
Vertex Pharmaceuticals Demonstrates Durable Islet Cell Therapy Effect for Type 1 Diabetes
Vertex Pharma disclosed one-year data indicating durable blood glucose control with their stem cell-derived islet cell therapy (zimislecel) in Type 1 diabetes patients. Most participants achieved...
Artificial Intelligence Advances Material Science and Semiconductor Research
Pioneering AI methods are revolutionizing materials science, including semiconductor thin-film growth and composite material design. Collaborations between institutes are integrating large...
Gene Editing Breakthroughs in Mitochondrial Disease Models
Researchers in the Netherlands successfully applied mitochondrial base editing using DdCBE technology to correct pathogenic mitochondrial DNA mutations in patient-derived models. This advancement...
Innovations in Cancer Diagnostics and Therapeutics: AI and Cellular Immunotherapy
Advanced AI tools have emerged to dissect intratumoral heterogeneity with precision, potentially transforming cancer treatment personalization. Meanwhile, CAR-T cell therapy advances confront...
Breakthrough Molecular Imaging Probes for Cancer and Infectious Diseases
New PET tracers targeting PD-L1 for head and neck cancer and glypican-3 for early hepatocellular carcinoma detection have shown enhanced specificity and imaging clarity. Concurrently, novel...
Regulatory and Leadership Shifts at the FDA amid Increased Agency Turnover
The FDA experiences a rapid turnover of senior leadership, including the administrative leave and departure of key executives within the Center for Biologics Evaluation and Research and Center for...