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Roche builds biggest AI factory in pharma — supercomputing push underway
Roche announced a large-scale investment to build an AI-driven discovery and development engine and signed a partnering agreement with Nvidia to secure the computing backbone for it. The Swiss...
White House lifts NIH spending hold — grants and hiring to restart
The White House lifted an Office of Management and Budget hold that had constrained the National Institutes of Health (NIH) from obligating its 2026 research budget. NIH Director Jayanta...
Federal court pauses HHS vaccine overhaul — ACIP and new schedule blocked
A federal judge issued a stay that halts major components of Health and Human Services Secretary Robert F. Kennedy Jr.’s changes to U.S. childhood vaccine policy and enjoined votes by the...
Structure's oral GLP‑1 posts injectable‑like results — Phase II data out
Structure Therapeutics released Phase II results showing its oral GLP‑1 candidate aleniglipron achieved substantial weight loss at 44 weeks, with analyses characterizing the pill’s efficacy as...
Masked ADCs show activity — CytomX updates as Astellas ends big collaboration
CytomX Therapeutics reported an encouraging expansion‑cohort response rate for its masked EpCAM ADC Varsetatug masetecan (Varseta‑M) in advanced colorectal cancer—data that included objective...
Bicycle Therapeutics shrinks after regulatory setback — lead ADC deprioritized
Bicycle Therapeutics said regulatory feedback forced it to abandon the accelerated approval path for its lead ADC zelenectide, converting a planned phase 2/3 registrational trial to phase 2 and...
Base editors advance: precision ABEs and in‑vivo rescue reported
Researchers reported two complementary advances in adenine base editing. First, a mutation‑reversion study produced minimally evolved ABEs with narrowed editing windows, improved on‑target...
Engineered E. coli drives intratumoral nitric oxide — tumors sensitized to PD‑L1 blockade
Two linked papers in Nature Biotechnology describe an engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine‑nitric oxide (NO) circuit that sustains intratumoral NO...
Manufacturing bottlenecks: integrated cell‑therapy systems and AI for gene‑therapy scale
Two industry moves targeted long‑standing manufacturing constraints for cell and gene therapies. Sartorius unveiled the Eveo Cell Therapy Platform, an integrated modular system meant to compress...
Diagnostics: FDA OKs Myriad MyChoice CDx and CMS covers NeoGenomics liquid biopsy
Myriad Genetics secured FDA approval for its MyChoice CDx as the companion diagnostic for GSK's PARP inhibitor Zejula, validating the test's genomic instability scoring and BRCA assessment for...
White House clears NIH apportionment: grants to resume
The Office of Management and Budget lifted a year-long restriction that had limited the National Institutes of Health to essential spending, allowing NIH to begin awarding new research grants. NIH...
Roche bets on an AI factory: Nvidia collab to power drug R&D
Roche announced plans to build a large-scale internal AI laboratory and struck a strategic deal with Nvidia to provision the computing infrastructure that will underpin the project. The...
Oral GLP-1s heat up: Structure posts 'injectable-like' Phase 2 win
Structure Therapeutics reported Phase 2 data showing its oral GLP-1 candidate aleniglipron achieved up to 16% placebo‑adjusted weight loss at 44 weeks, positioning the pill as a potential oral...
Masked ADC shows activity in CRC... Investors take notice
CytomX updated clinical data for its conditionally activated (masked) EpCAM-targeting ADC, Varsetatug masetecan (Varseta‑M), reporting objective response rates of about 32% at a 10 mg/kg dose in...
Astellas walks away: $1.6B CytomX pact ends
Astellas Pharma terminated its multi‑target collaboration with CytomX that originally carried up to $1.6–$1.7 billion in milestones. The partnership—launched in 2020 to apply CytomX’s Probody...
Metapipeline‑DNA standardizes sequencing: automated genomics at scale
A team from Sanford Burnham Prebys and UCLA released metapipeline‑DNA, a Nextflow‑based automated pipeline for germline and somatic genomics that standardizes and scales DNA sequencing analysis...
AlphaFold expands to complexes: millions of protein interactions added
EMBL‑EBI, DeepMind, NVIDIA and collaborators released a massive expansion of AI‑predicted protein complex structures to the AlphaFold Database, providing millions of models for multi‑protein...
PerturbAI releases 8M‑cell CRISPR atlas—startup emerges from stealth
PerturbAI announced the public release of an in vivo Perturb‑seq CRISPR atlas mapping gene function across 8 million brain cells and emerged from stealth with undisclosed pre‑seed funding. The...
FDA clears Myriad MyChoice as Zejula companion: ovarian CDx approved
Myriad Genetics received FDA approval for its MyChoice CDx test as a companion diagnostic to identify homologous recombination deficiency (HRD) and BRCA mutations in patients eligible for GSK’s...
FDA rejects Aldeyra again: third CRL for reproxalap
The FDA issued a third complete response letter to Aldeyra Therapeutics for reproxalap, the company’s dry eye disease candidate, citing inconsistent and insufficient evidence of efficacy across...