Get the Daily Brief
Latest Biotech News
Guardant patent fight remanded: appeals court sends case back to PTAB
The U.S. Court of Appeals for the Federal Circuit remanded Guardant Health’s patent dispute with TwinStrand Biosciences and the University of Washington to the Patent Trial and Appeal Board for...
Diploid Genomics launches: Venter‑led spinout promises AI genomics analytics
A new JCVI spinout, Diploid Genomics, cofounded by J. Craig Venter and seeded by Healthier Capital, launched with plans to build an AI‑driven genomics analytics and diagnostics platform. The...
Macrophage‑targeted CAR T: Trojan horse approach reprograms solid tumor microenvironment
Researchers at the Icahn School of Medicine and collaborators reported IL‑12‑producing CAR T cells that target tumor‑associated macrophages (TAMs) and remodel the immunosuppressive tumor...
SPARK trial posts activity: sitravatinib plus tislelizumab shows signals in TNBC
A cohort in the SPARK trial reported activity for the combination of sitravatinib and tislelizumab in locally recurrent or metastatic triple‑negative breast cancer. The multi‑cohort phase II...
Moderna pulls back from late‑stage vaccine trials amid political pushback
Moderna said it is curbing investments in late‑stage infectious disease vaccine trials following political backlash in the U.S., a move reported amid industry concerns about the policy environment...
NVIDIA, Lilly Build $1B AI Lab—Drug Discovery Reboot
NVIDIA and Eli Lilly announced a $1 billion collaboration to build an AI-powered drug discovery laboratory in the San Francisco Bay Area. The partnership will combine NVIDIA’s AI hardware and...
Wegovy Pill Ramps Up... Prescriptions Spike 500% Week Two
Novo Nordisk reported a rapid initial uptake for its oral Wegovy weight‑loss pill, with prescriptions ramping up roughly 500% in the product’s second week on the market. Analysts flagged strong...
Erasca Upsized Offering—$258.8M Raised
Erasca closed an upsized public offering, selling 25,875,000 shares at $10 per share to raise approximately $258.8 million in gross proceeds. The clinical‑stage precision oncology company said the...
Sanofi to File for Eczema Drug Despite Mixed Phase III Data
Sanofi said it will seek regulatory approval for amlitelimab in atopic dermatitis despite mixed Phase III results across trials. The company reported that one pivotal study met primary endpoints...
Trojan‑Horse CAR T: Macrophage Targeting Reshapes Tumors
Researchers at the Icahn School of Medicine at Mount Sinai reported that IL‑12‑producing CAR T cells targeting tumor‑associated macrophages (TAMs) improved survival in aggressive mouse models of...
Protein Sequencing Startup Encodia Shuts Down—Lab Assets Up for Sale
Encodia, a San Diego protein‑sequencing company that developed a DNA‑tagging ProteoCode approach, ceased operations late last year and has begun auctioning laboratory equipment, GenomeWeb...
Appeals Court Remands Guardant Patent Ruling to PTAB
The U.S. Court of Appeals for the Federal Circuit remanded a patent infringement dispute involving Guardant Health, TwinStrand Biosciences and the University of Washington back to the Patent Trial...
FDA Targets Cuffless Blood‑Pressure Monitors in New Draft Guidance
The FDA’s Center for Devices and Radiological Health issued draft guidance focused on cuffless blood‑pressure monitoring devices, signaling tighter oversight as over‑the‑counter, cuffless products...
Moderna Scales Back Late‑Stage Vaccine Trials—Political Backlash Cited
Moderna is curbing investments in late‑stage vaccine trials following backlash in the U.S., according to reporting that cited the company’s CEO. The move reflects mounting political and public...
Venter Cofounder Launches Diploid Genomics—AI Meets Clinical Sequencing
A new JCVI spinout, Diploid Genomics, cofounded by J. Craig Venter, launched with seed funding from Healthier Capital to build an AI‑driven genomics analytics platform for research and...
Erasca upsized offering: nets $258.8M
Erasca closed an upsized public offering, selling 25,875,000 shares at $10.00 each and generating approximately $258.8 million in gross proceeds. The company said all shares were sold by Erasca...
Corxel draws $287M to advance oral GLP‑1
Corxel Pharmaceuticals completed a $287 million Series D to fund global development of CX‑11, an oral small‑molecule GLP‑1 receptor agonist for obesity and overweight patients. The financing will...
Mendra raises $82M Series A – AI‑driven rare disease play
Mendra secured $82 million in Series A financing to build a company focused on acquiring, developing and commercializing therapies for rare diseases. The round, co‑led by OrbiMed, 8VC and 5AM...
NVIDIA, Eli Lilly build $1B AI lab: drug discovery gets heavy bet
NVIDIA and Eli Lilly announced a $1 billion partnership to create an AI‑powered drug discovery laboratory in the San Francisco Bay Area. The collaboration combines NVIDIA’s computing platforms and...
Sanofi to file for amlitelimab despite mixed phase 3
Sanofi said it will pursue global regulatory submissions for amlitelimab in atopic dermatitis based on the totality of data even though additional phase III results showed mixed outcomes across...