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Breakthrough Imaging Identifies Early Parkinson’s via Speech Fusion Architecture
Advancements integrating artificial intelligence with neurological diagnostics have led to the development of a fusion architecture leveraging semi-supervised speech embeddings for early detection...
FDA Leadership Shakeup in Cell and Gene Therapy Division Sparks Industry Concern
The Food and Drug Administration has placed the director and deputy of its cell and gene therapy office on administrative leave, escorting both out of the agency. This sudden leadership departure,...
Lanthanide-carbon triple bond stabilized inside fullerene cage
Researchers at the frontier of coordination and organometallic chemistry have synthesized a unique lanthanide–carbon triple bond encapsulated within an endohedral fullerene cage, specifically a...
Therapeutic Potential of Menin Inhibition in Acute Leukemias
Acute leukemias, notably acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), are aggressive hematologic malignancies characterized by dysregulated hematopoietic proliferation,...
In vivo creation of CAR T cells via targeted lipid nanoparticles
Researchers have innovated a novel immunotherapeutic strategy enabling the in vivo generation of chimeric antigen receptor (CAR) T cells, bypassing traditional ex vivo cell manufacturing....
Advancements in nanoparticle drug delivery with protein-polymer coassembly
Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have developed a novel nanoparticle system by coassembling PLGA, a biodegradable medical polymer, with albumin, a naturally...
Gilead gains FDA approval for twice-yearly HIV PrEP injection Yeztugo
The FDA has approved Gilead Sciences’ lenacapavir (Yeztugo) as the first twice-yearly injection for pre-exposure prophylaxis (PrEP) against HIV. Clinical trials demonstrated nearly 100% efficacy...
Virtual Reality Enhances Stroke Rehabilitation Outcomes
A comprehensive Cochrane review encompassing 190 trials and over 7,000 stroke patients highlights virtual reality (VR) as a beneficial adjunct therapy for improving arm motor function during...
FDA Commissioner Makary pushes for modernized drug review pathways
FDA Commissioner Martin Makary unveiled a pilot Commissioner’s National Priority Voucher (CNPV) program aiming to accelerate drug reviews for medicines addressing U.S. national priorities such as...
New insights into PTSD brain cell communication deficits
Using advanced single-nucleus RNA sequencing and chromatin accessibility assays, researchers mapped over two million nuclei from human prefrontal cortex samples from PTSD patients, depressed...
Advancements in 3D immunohistochemistry with nanobody conjugates
Researchers at Juntendo University have developed a novel 3D immunohistochemistry technique enhancing rapid and deep tissue imaging, significantly reducing traditional processing times. The method...
Lanthanide–Carbon Triple Bond Discovery Locked in Fullerene Cage
Researchers have synthesized a lanthanide–carbon triple bond encapsulated within an endohedral fullerene cage, specifically a cerium–carbide cluster [Ce≡CSc2] inside a C80 fullerene. This...
FDA Launches Commissioner’s National Priority Voucher to Expedite Drug Reviews
The U.S. Food and Drug Administration (FDA) announced a pilot program offering Commissioner’s National Priority Vouchers (CNPVs) that enable certain drugs addressing national health priorities to...
Gilead Secures FDA Approval for Twice-Yearly HIV Prevention Injection
Gilead Sciences achieved a landmark FDA approval for lenacapavir (brand name Yeztugo), the first HIV pre-exposure prophylaxis (PrEP) drug administered twice yearly by injection. This long-acting...
In Vivo Generation of CAR T Cells Using Targeted Lipid Nanoparticles
A novel immunotherapy approach enables direct in vivo creation of CAR T cells using targeted lipid nanoparticles (tLNPs), bypassing complex ex vivo cell engineering processes. This strategy...
Parkinson’s Disease Sleep Dysfunction Ameliorated by Butyrate Through BDNF Pathway
A study demonstrates that butyrate, a short-chain fatty acid produced by gut microbiota, restores abnormal sleep architecture in a Parkinson’s disease mouse model by activating the brain-derived...
Patient-Centric Focus Drives Biotech Innovation at BIO 2025 Convention
At the 2025 BIO International Convention, industry leaders reiterated the centrality of patients to biotechnology innovation. Panels highlighted the vital role of patient advocacy, including...
New Scheduling Model Enhances Neonatal Intensive Care Efficiency and Staff Wellbeing
A cutting-edge hours-based scheduling system tailored for neonatal intensive care units (NICUs) has been developed to improve patient outcomes and provider wellbeing. Departing from traditional...
Critical Gaps in Environmental Chemical Monitoring Threaten Aquatic Ecosystem Safety
Recent investigations reveal substantial shortcomings in chemical monitoring programs, with under 1% of the estimated 300,000 chemicals of environmental concern regularly assessed in U.S. surface...
Zealand Pharma’s Dual GLP-1/GLP-2 Agonist Demonstrates Robust Weight Loss in Phase 1b
Zealand Pharma reported updated phase 1b results for its dapiglutide, a dual glucagon-like peptide-1 and peptide-2 receptor agonist, showing an average body weight reduction of 11.6% after 28...