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Human Gut Bacteria Can Capture and Remove PFAS Chemicals
Researchers have identified specific human gut bacterial strains capable of accumulating perfluoroalkyl and polyfluoroalkyl substances (PFAS), commonly known as 'forever chemicals,' which are...
FDA Drops CAR T Therapy Guardrails – CGT Fields React
The FDA has removed Risk Evaluation and Mitigation Strategies (REMS) for six CAR T cell therapies targeting BCMA and CD19 antigens in multiple myeloma and hematologic malignancies. This decision...
CRISPR Erases Extra Chromosome in Down Syndrome Cells
Scientists in Japan have achieved a pioneering breakthrough by utilizing CRISPR-Cas9 to selectively remove the extra chromosome 21 responsible for Down syndrome in lab-grown human stem and skin...
Linking Metabolism and Immune Cell Fate in Cancer and Infection
Recent studies have elucidated critical metabolic mechanisms shaping immune cell behavior. Research highlights glucose metabolism's central role in steering CD4+ T cell differentiation,...
Noninvasive Cancer Diagnostics Advance via Epigenetic Biomarkers
Innovations in cancer detection are progressing with novel noninvasive tests leveraging gene methylation patterns. A method utilizing automatically processed bilateral nasal swabs can detect...
Neuroscience Reveals New Insights Into Brain Plasticity and Resilience
Groundbreaking neuroscience research reveals how thalamocortical structural connectivity develops alongside cortical plasticity hierarchies, expanding understanding of brain maturation. Additional...
Gut Microbiome Tackles Environmental Toxins and Disease
Emerging research reveals key roles of gut bacteria in environmental and clinical contexts. Certain human gut strains have been identified to accumulate and remove PFAS ‘forever chemicals,’...
Innovations in Oncology: CAR-NKT Cells and GBM Immunotherapies
Novel therapeutic modalities show promise in oncology. Brightpath Biotherapeutics’ BCMA CAR-natural killer T cell candidate BP-2202 received FDA orphan drug designation for multiple myeloma,...
Environmental and Climate Science Unveil Emerging Risks and Mechanisms
Cutting-edge environmental research details intense climate change impacts and human vulnerability. Studies demonstrate early detectable climate fingerprints using extensive simulations,...
Plant Biology Deciphers Environmental Signal Integration and Defense
Advances in plant molecular biology elucidate mechanisms of environmental responsiveness and defense. Research demonstrates how temperature elevations boost FKF1 protein to trigger flowering,...
Clinical and Therapeutic Advances in Liver and Bladder Cancer
Significant progress has been made in targeting liver and bladder malignancies. Identification of S100A4’s role in driving hepatocellular carcinoma metastasis via interaction with NMIIA elucidates...
CRISPR Erases Extra Chromosome in Down Syndrome Cells
Japanese researchers at Mie University have successfully used CRISPR-Cas9 gene editing to remove the extra chromosome 21 responsible for Down syndrome in cultured human stem and skin cells. This...
FDA Removes REMS from CAR-T Therapies to Enhance Access
The FDA has eliminated Risk Evaluation and Mitigation Strategies (REMS) from six approved CAR-T cell therapies targeting BCMA and CD19 antigens used in multiple myeloma and certain leukemias and...
New Noninvasive Gene Methylation Test Detects Nasopharyngeal Cancer Early
Researchers developed a novel, noninvasive diagnostic technique utilizing DNA methylation biomarkers obtained from bilateral nasal swabs processed automatically to detect nasopharyngeal carcinoma....
Metabolic Reprogramming Drives Immune Evasion in Melanoma Therapy
New insights into melanoma tumor metabolism reveal metabolic reprogramming as a significant barrier to effective immunotherapy. Complex interactions within the tumor microenvironment inhibit...
Gene Editing Advances Target Aggressive Bladder Cancer Pathways
Researchers uncovered the role of transcription factor TCF3 in bladder cancer progression via modulation of the TMBIM6-Ca²⁺ ferroptosis pathway. This novel mechanism offers potential therapeutic...
AI-Powered Framework Deciphers Gut Microbiome and Metabolite Interactions
A team from the University of Tokyo introduced VBayesMM, an advanced artificial intelligence platform employing variational Bayesian neural networks, to analyze complex relationships between human...
Long-Acting Injectable Combo Shows Promise for HIV Treatment in Africa
A recent study published in Nature Communications evaluated the efficacy and cost-effectiveness of combining long-acting injectable antiretrovirals lenacapavir and cabotegravir for HIV treatment...
Novel Plasma Method Converts Air into Ammonia for Sustainable Production
Researchers at the University of Sydney developed an innovative plasma-driven technique to synthesize ammonia directly from atmospheric nitrogen, bypassing traditional energy-intensive Haber-Bosch...
Synthetic Gait Data Enhances Musculoskeletal Healthcare Applications
A 2025 Nature Communications study presents the utility of synthetic musculoskeletal gait data generated through AI for clinical and research purposes. By simulating diverse gait patterns, this...