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Takeda’s narcolepsy drug posts twin phase 3 victories, FDA filing imminent
Takeda Pharmaceutical is advancing its orexin receptor 2 (OX2R)-selective agonist toward regulatory submission after achieving two positive phase 3 trial outcomes. These results position the drug...
AstraZeneca’s $1.3B CinCor acquisition validated by hypertension phase 3 success
AstraZeneca's sizable $1.3 billion investment in CinCor Pharmaceuticals gains justification with a positive phase 3 trial of baxdrostat, an aldosterone synthase inhibitor. Conducted in 796...
Repligen and Univercells unite on real-time viral vector biomanufacturing monitoring
Repligen Technologies and Univercells Technologies announced a collaboration integrating Repligen’s MAVEN® Real Time Glucose Control Platform into Univercells' scale-X bioreactors to deliver...
Genetic diversity influences tumor response to immunotherapy, mouse model reveals
Research using the Collaborative Cross mouse model, designed for genetic variability, elucidates how inherited genetic differences impact tumor response to immune checkpoint inhibitors. Findings,...
Novel ubiquitination pathway modulated by cypin shapes synaptic plasticity for brain therapeutics
A Rutgers University study uncovers the role of the protein cypin in regulating synaptic content through K63-linked polyubiquitination (polyUb), a post-translational modification previously...
Emerging Alzheimer’s research reveals hundreds of misfolded proteins beyond amyloids
Johns Hopkins researchers employing limited proteolysis mass spectrometry (LiP-MS) identified over 200 misfolded proteins associated with cognitive decline in aged rat models, challenging the...
Study links wildfire smoke exposure to heightened cardiovascular events and mortality
A large-scale study analyzing 3.2 million adults in Northern California found a significant increase in cardiovascular hospitalizations and mortality during the 2018 Mendocino Complex wildfire...
Marathon running induces reversible decreases in brain myelin content, study finds
Magnetic resonance imaging of 10 marathon runners revealed significant short-term reductions in myelin water fraction, a proxy for myelin, in key white matter regions immediately post-race. These...
Fecal microbiota transplantation explored beyond C. difficile for broad therapeutic potential
Fecal microbiota transplantation (FMT), originally validated for recurrent Clostridioides difficile infection, is gaining investigation across diverse conditions including alopecia, depression,...
Urgency in pharma drives data integration to resolve speed-trust paradox in decision making
Pharmaceutical organizations face mounting pressure to accelerate drug development while maintaining regulatory trust and patient safety. Despite digital investments, fragmented data systems...
AstraZeneca’s $1.3B Bet Pays Off: Baxdrostat’s Phase 3 Win in Hypertension
AstraZeneca announced positive phase 3 results for baxdrostat, a blood pressure drug acquired from CinCor Pharma. In a late-stage trial with 796 patients suffering uncontrolled hypertension,...
Mitochondrial NAD+ Pools Crucial in Aging Cell Metabolism
New research from the University of Bergen reveals that mitochondrial nicotinamide adenine dinucleotide (NAD+) pools are critical in cellular aging. Employing a model of constitutive NAD+...
Wildfire Smoke Elevates Cardiovascular Events and Mortality in Northern California
A study by Kaiser Permanente cardiology researchers linked wildfire smoke exposure to increased cardiovascular hospitalizations and mortality. Analysis of over 3 million adults during 2018...
Genetic Variability Influences Tumor Response to Immunotherapy
A collaborative study at The Jackson Laboratory employed genetically diverse mouse models to elucidate how inherited variation affects tumor response to immune checkpoint inhibitors. Their...
Repligen and Univercells Integrate Real-Time Monitoring for Viral Vector Manufacturing
Repligen has partnered with Univercells Technologies to integrate MAVEN® glucose and lactate real-time monitoring into scale-X bioreactors for adherent cell culture. This process analytical...
Proteomic Study Uncovers Widespread Misfolded Proteins in Alzheimer’s Model
Johns Hopkins researchers using limited proteolysis mass spectrometry identified over 200 types of misfolded proteins associated with age-related cognitive decline in rats, suggesting amyloid-beta...
Synaptic Plasticity Control via Cypin and K63-Linked Polyubiquitination Unveiled
Rutgers University scientists discovered that the neuronal protein cypin regulates synaptic protein content through modulation of K63-linked polyubiquitination. This process affects proteasome...
Brain Myelin Temporarily Depletes After Marathon Running but Recovers
A study involving MRI scans of marathon runners documented significant short-term decreases in myelin water fraction, a proxy for myelin content, in key white matter regions immediately post-race....
FDA Publishes Over 200 Drug Rejection Letters to Enhance Transparency
The FDA released more than 200 complete response letters (CRLs) as part of efforts to modernize and increase transparency in drug regulatory communications. While this step represents a...
Aging Cells Regulate NAD+ via Mitochondria to Maintain Metabolism
Research from the University of Bergen details how aging cells manage declining nicotinamide adenine dinucleotide (NAD+) levels through mitochondrial pools. Using a chronic depletion model, the...