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Combined Electrical and Brain Stimulation Boosts Early Post-Stroke Recovery
A pioneering clinical study demonstrates that integrating contralateral controlled functional electrical stimulation (CCFES) with transcranial direct current stimulation (tDCS) significantly...
Study Links Maternal Obesity and Infant Growth via Milk Leptin Levels
New findings published in Pediatric Research reveal how maternal obesity alters leptin concentrations in breast milk, influencing infant growth trajectories in the first six months. This research...
Sage’s Zurzuvae Deal Fails After Biogen Acquisition Bid Rebuffed
Following FDA setbacks for its depression drug Zurzuvae and pipeline failures, Sage Therapeutics pursued partnerships throughout 2024, ultimately entering a $795 million acquisition agreement with...
FDA Drops CAR T Therapy Guardrails – CGT Community Applauds Move
The FDA has removed Risk Evaluation and Mitigation Strategies (REMS) for six CAR T cell therapies targeting BCMA and CD19 antigens, marking a significant shift in regulatory policy. This decision...
CRISPR Edits Out Down Syndrome Chromosome in Lab Cells
Scientists at Mie University in Japan have successfully utilized CRISPR-Cas9 to remove the extra chromosome 21 responsible for Down syndrome in cultured human cells. This allele-specific gene...
Noninvasive Gene Methylation Test Advances Nasopharyngeal Cancer Detection
Researchers have developed a novel, non-invasive diagnostic method for nasopharyngeal carcinoma by analyzing DNA methylation biomarkers from bilateral nasal swabs processed automatically. This...
Metabolic Reprogramming Shapes Melanoma Immunotherapy Resistance
Recent studies have revealed the critical role of metabolic dynamics within the melanoma tumor microenvironment in mediating immune evasion and limiting immunotherapy effectiveness. Alterations in...
AI Framework Deciphers Gut Microbiome-Metabolite Interactions
Scientists at the University of Tokyo have introduced VBayesMM, an advanced artificial intelligence platform utilizing variational Bayesian neural networks to elucidate complex interactions...
Heat Accelerates FKF1 to Trigger Plant Flowering Mechanisms
Researchers have identified that elevated temperatures enhance the activity of FKF1, a key protein regulating the floral transition in plants. This environmental cue integrates with photoperiod...
Robotic Probe Accelerates Evaluation of Novel Semiconductor Materials
An autonomous robotic system developed at MIT enables rapid, reliable assessment of critical properties in new semiconductor materials for solar technologies. This innovation addresses bottlenecks...
Glucose Metabolism Directs CD4+ T Cell Differentiation Pathways
New research highlights how glucose metabolism critically influences the fate decisions of naive CD4+ T lymphocytes upon antigenic stimulation. Metabolic shifts regulate differentiation into...
Link Between Serum LDH Levels and Cancer Mortality Revealed
A large retrospective cohort study published in BMC Cancer demonstrates a U-shaped association between serum lactate dehydrogenase (LDH) levels and all-cause mortality in cancer patients. Both...
Human Gut Bacteria Can Capture and Remove PFAS Chemicals
Researchers have identified specific human gut bacterial strains capable of accumulating perfluoroalkyl and polyfluoroalkyl substances (PFAS), commonly known as 'forever chemicals,' which are...
FDA Drops CAR T Therapy Guardrails – CGT Fields React
The FDA has removed Risk Evaluation and Mitigation Strategies (REMS) for six CAR T cell therapies targeting BCMA and CD19 antigens in multiple myeloma and hematologic malignancies. This decision...
CRISPR Erases Extra Chromosome in Down Syndrome Cells
Scientists in Japan have achieved a pioneering breakthrough by utilizing CRISPR-Cas9 to selectively remove the extra chromosome 21 responsible for Down syndrome in lab-grown human stem and skin...
Linking Metabolism and Immune Cell Fate in Cancer and Infection
Recent studies have elucidated critical metabolic mechanisms shaping immune cell behavior. Research highlights glucose metabolism's central role in steering CD4+ T cell differentiation,...
Noninvasive Cancer Diagnostics Advance via Epigenetic Biomarkers
Innovations in cancer detection are progressing with novel noninvasive tests leveraging gene methylation patterns. A method utilizing automatically processed bilateral nasal swabs can detect...
Neuroscience Reveals New Insights Into Brain Plasticity and Resilience
Groundbreaking neuroscience research reveals how thalamocortical structural connectivity develops alongside cortical plasticity hierarchies, expanding understanding of brain maturation. Additional...
Gut Microbiome Tackles Environmental Toxins and Disease
Emerging research reveals key roles of gut bacteria in environmental and clinical contexts. Certain human gut strains have been identified to accumulate and remove PFAS ‘forever chemicals,’...
Innovations in Oncology: CAR-NKT Cells and GBM Immunotherapies
Novel therapeutic modalities show promise in oncology. Brightpath Biotherapeutics’ BCMA CAR-natural killer T cell candidate BP-2202 received FDA orphan drug designation for multiple myeloma,...