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Novel Molecular Glue Degrader Programs Propel Cancer Drug Development
Targeted protein degradation gains momentum as Kymera Therapeutics expands partnerships and clinical candidates. The company’s collaboration with Sanofi pivots to advancing a new IRAK4 degrader...
FDA and NIH Publish Unified Real-World Evidence Glossary to Standardize Research
The FDA and NIH jointly released the Modernizing Research and Evidence (MoRE) Consensus Definitions draft glossary to harmonize terminology in clinical and real-world evidence (RWE) research....
Generative AI Enhances Cancer Care at City of Hope
City of Hope has introduced a novel generative AI platform, HopeLLM, that leverages extensive oncology data and advanced models to streamline patient onboarding, personalize clinical trial...
Kymera Therapeutics Targets CDK2 in Cancer With New Partnerships
Kymera Therapeutics has signed a deal with Gilead Sciences to develop molecular glue degraders targeting cyclin-dependent kinase 2 (CDK2) for solid tumors including breast cancer, potentially...
FDA Investigates Sarepta’s Duchenne Gene Therapy After Patient Deaths
The FDA is reviewing safety concerns related to Sarepta Therapeutics’ gene therapy Elevidys for Duchenne muscular dystrophy following two patient deaths attributed to acute liver failure. Both...
Breakthroughs in Mitochondrial DNA Base Editing for Disease Models
Researchers from University Medical Center Utrecht and collaborators have successfully applied mitochondrial base editing to correct pathogenic mitochondrial DNA mutations in patient-derived human...
Advances in AI for Drug Discovery and Genomics
Gero introduced ProtoBind-Diff, a structure-free diffusion language model that designs drug-like molecules guided solely by protein amino acid sequences. Trained on over a million protein-ligand...
Immunotherapy Insights in Brain and Tumor Microenvironments
Studies reveal critical immune mechanisms influencing cancers in the central nervous system and glioblastoma. Hernandez-Barranco and Joyce identified interferon-gamma-activated dendritic cells...
Precision Diagnostics and Clinical Guidelines Impacting Cancer Care
Adaptive Biotechnologies’ stock rose following new NCCN multiple myeloma guidelines recommending baseline clonotype identification or aspirate storage at diagnosis to facilitate minimal residual...
Innovations in Renewable Energy and Environmental Technologies
Researchers have advanced perovskite solar cells optimized for indoor fluorescent light, enabling efficient electrical power generation in artificial lighting conditions. Another team developed a...
AI and Machine Learning Streamline Cell Therapy and Medical Device Testing
Cutting-edge approaches integrate machine learning with UV absorbance spectroscopy to rapidly detect microbial contamination in cell therapies within 30 minutes, enhancing sterility assurance...
Human ENS Cell Transplants Restore Gut Motility in Mice
Researchers have demonstrated the successful transplantation of human pluripotent stem cell (hPSC)-derived nitrergic neurons into the colonic wall of immunocompromised mice deficient in nitric...
Mexico Fortifies Ban on Genetically Modified Corn, Sparking Scientific Debate
Mexico has constitutionally expanded its ban on genetically modified (GM) corn to include all genetic engineering techniques such as CRISPR, intensifying controversy among scientists. The move...
Axolotl Limb Regeneration Decoded Through Molecular Positional Memory
A study published in Nature elucidates the molecular mechanisms by which axolotl limb cells retain positional memory after amputation, guiding accurate regeneration. Researchers identified key...
US CDC Vaccine Panel Overhaul Raises Concerns Over Childhood Vaccination Policies
The Advisory Committee on Immunization Practices (ACIP), recently reshaped by Health Secretary Robert F. Kennedy Jr., held its first meeting marking a significant shift in vaccine oversight. The...
Medicare Drug Spending Growth to Decelerate Due to Inflation Reduction Act
Economists at the Centers for Medicare & Medicaid Services (CMS) project a slowdown in Medicare prescription drug spending growth between 2028 and 2033, attributable to drug price negotiation...
Nuclear CDK Activation in Cell Division Initiates in the Nucleus, Not Cytoplasm
Contrary to prevailing models, recent research reveals that cyclin-dependent kinase (CDK) activation triggering mitosis occurs primarily within the cell nucleus rather than at cytoplasmic...
AI Model ProtoBind-Diff Enables Drug-Like Molecule Design from Protein Sequences
Gero has introduced ProtoBind-Diff, a masked diffusion language model that generates novel drug-like molecules conditioned solely on protein amino acid sequences, foregoing the need for structural...
TTYH2 and APOE Interaction Illuminates Endosomal Lipid Transfer Mechanisms
Structural biology studies employing cryo-electron microscopy and biochemical reconstitution have revealed how the membrane protein TTYH2 interacts with disc-shaped APOE-containing lipoprotein...
AI Enhances Breast Cancer Detection with Largest Open-Source MRI Dataset
Researchers from The City College of New York and Memorial Sloan Kettering Cancer Center developed an interpretable deep learning model achieving high accuracy in detecting and localizing breast...