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Immuno-Oncology Setbacks: Billions Lost on TIGIT Targeted Therapies
Pharma's once-promising TIGIT immuno-oncology target has collapsed after costly clinical failures, leading to billions lost. Key players including Bristol Myers Squibb, Gilead, GSK, and Novartis...
Ultrarare Disease Gene Therapies: Advances and Challenges
Recent advances in gene-editing technologies and regulatory approaches are enabling the development of therapies for ultrarare diseases affecting fewer than one in 50,000 people. A landmark case...
Alzheimer’s M&A Soars Post-Leqembi, Kisunla Approvals
Following FDA approvals of monoclonal antibodies Leqembi and Kisunla for Alzheimer’s disease, dealmaking in the space has surged dramatically. GlobalData reports Alzheimer’s M&A deal values jumped...
AI-Driven Drones and Precision Farming Innovations
Researchers at The Hebrew University of Jerusalem and partners have developed advanced drone systems integrating hyperspectral, thermal, and RGB sensors with AI algorithms to detect nitrogen and...
Breakthroughs in RNA Therapy Delivery and Efficacy
A University of Basel study published in Nature Communications reveals novel intracellular mechanisms restricting antisense oligonucleotide (ASO) therapies' effectiveness and identifies strategies...
Cancer Treatment Advances: New Targets and Radiotheranostics
Recent developments in oncology include Amgen’s FGFR2b-targeting antibody showing significant overall survival gains in a Phase 3 stomach cancer trial, albeit with ocular side effects raising...
Biotech Financing and Restructuring: Navigating Market Pressures
Applied DNA Sciences has restructured to focus on synthetic DNA manufacturing by closing its clinical lab and cutting 27% of staff, aiming to reduce costs and scale nucleic acid therapy...
AI and Biotech Integration: Accelerating Drug Discovery and Clinical Development
Innovative AI models developed by an OpenAI-backed startup have exhibited superior success in designing antibodies experimentally, outperforming existing protein modeling tools. Pfizer enhanced...
AbbVie’s $2.1 Billion Bet on In Vivo CAR-T - Capstan Deal
AbbVie has executed a major acquisition by purchasing Capstan Therapeutics for up to $2.1 billion, marking its entrance into the in vivo CAR-T therapy market. Capstan, founded in 2022, focuses on...
Moderna’s Flu Vaccine Wins Phase 3, FDA Submissions Expected
Moderna announced compelling phase 3 results for its mRNA-1010 influenza vaccine, demonstrating 26.6% improved efficacy over a licensed standard-dose comparator in adults 50 years and older. The...
Applied DNA Sciences Restructures to Prioritize Synthetic DNA Manufacturing
Applied DNA Sciences announced a strategic shift to focus exclusively on synthetic DNA manufacturing through its LineaRx subsidiary. The company ceased operations at its molecular and genetic...
Tempus AI Raises $400 Million to Reduce Debt Burden
Tempus AI announced plans to raise $400 million through convertible senior notes to pay down existing debt and reduce interest costs. The offering, maturing in 2030, includes an option for an...
Breakthroughs in Brain Disease Research: Glycogen’s Role in Neurodegeneration
Researchers at the Buck Institute have uncovered that neuronal glycogen accumulation exacerbates tauopathies like Alzheimer’s disease by impairing oxidative stress management. Restoration of...
AI Advances in Antibody Discovery and Drug Modeling
A San Francisco startup supported by OpenAI launched AI models capable of designing antibodies with significantly higher lab success rates compared to existing protein models. Concurrently, Pfizer...
Thermo Fisher’s Integrated CRO-CDMO Model Slashes Oncology Development Time
According to a Tufts University study commissioned by Thermo Fisher Scientific, the company’s Accelerator solutions integrating CRO and CDMO services reduce cancer drug development timelines by up...
New Radiotheranostics and Targeted Cancer Therapies Show Progress
Actinium Pharmaceuticals presented promising data for ATNM-400, a radioconjugate targeting a non-PSMA tumor antigen in prostate cancer and other tumors, using actinium-225. Additionally, Vitsgen...
Microbiome Preservation and Environmental Biosensing Innovations
The Microbiota Vault Initiative celebrated a significant phase in its effort to ethically preserve global microbial diversity amid threats from human activities. The project outlined principles...
FDA Clears Rocket Pharmaceuticals’ Gene Therapy IND for Cardiomyopathy
The U.S. FDA has approved Rocket Pharmaceuticals’ investigational new drug application for RP-A701, a gene therapy candidate based on the AAVrh.74 vector targeting BAG3-associated dilated...
AI Transforms Antibody Discovery with New Protein Models
Chai Discovery, a San Francisco-based startup, has introduced cutting-edge AI models for de novo antibody generation that demonstrate significantly improved success rates compared to existing...
Neuronal Glycogen Breakdown Offers New Hope Against Tauopathies
Researchers from the Buck Institute and collaborators have identified how neuronal glycogen breakdown mitigates tau pathology associated with neurodegenerative diseases like Alzheimer's and...