Get the Daily Brief
Latest Biotech News
Crossbow closes $77m Series B to push T‑cell engager into clinic
Crossbow Therapeutics closed a $77 million Series B to advance its T‑Bolt platform and complete the Phase I study of CBX‑250, the company said. CEO Briggs Morrison told BioXconomy the financing...
Novartis inks up to $3B deal for mutant‑selective PI3Kα program
Novartis agreed to acquire Pikavation Therapeutics for up to $3 billion to add SNV4818, a pan‑mutant selective PI3Kα inhibitor, to its oncology pipeline. Novartis framed the deal as a move to...
CytomX posts 32% ORR in mCRC dose expansion; shares roller‑coaster
CytomX reported positive dose‑expansion data for varsetatug masetecan (varseta‑M) in metastatic colorectal cancer, delivering a 32% overall response rate and median progression‑free survival of...
Reinforced biotubes unveiled as off‑the‑shelf regenerative vascular grafts
Researchers published reinforced biotubes in Nature Communications, describing a new class of regenerative vascular grafts engineered to mimic native vessel scaffolding and support host...
Alectinib plus CAR T shows synergy in ALK‑driven neuroblastoma models
Preclinical work found that the ALK inhibitor alectinib enhances CAR‑T cell cytotoxicity against ALK‑mutant neuroblastoma, the study reports. Investigators demonstrated improved tumor cell killing...
HKUST deciphers how DICER trims microRNAs with single‑nucleotide precision
A research team at The Hong Kong University of Science and Technology revealed the molecular mechanism by which human DICER processes microRNAs with single‑nucleotide accuracy. The work elucidates...
ADA2 deficiency linked to rampant cell death and metabolic collapse
A study in Cell Death Discovery reported that cells lacking adenosine deaminase 2 (ADA2) show markedly increased cell death accompanied by severe metabolic dysfunction. Authors mapped metabolic...
Acinetobacter capsule biology alters antibiotic resistance and host immunity
Researchers dissected how capsular polysaccharides in Acinetobacter species modulate drug resistance and immune evasion. The paper details capsule‑dependent effects on antibiotic penetration,...
New antimalarial dimers discovered in deep‑sea fungus
Scientists isolated two novel dimeric compounds, piperasagamines A and B, from a deep‑sea Aspergillus strain (FKJ‑0404) and reported antimalarial activity in early studies. The structures...
Pocket DART scope and Human Organ Atlas push faster, label‑free molecular imaging
Two imaging innovations promise to speed molecular mapping in biology and clinical research. A deep‑UV DART pocket‑scope delivers fast, label‑free imaging of DNA and proteins using deep‑UV light,...
Crossbow raises $77M to advance T‑cell engager program
Crossbow Therapeutics closed a $77 million Series B to advance its T‑cell engager pipeline, the company said. Cambridge, Massachusetts–based Crossbow will use the funds to complete a Phase I trial...
Novartis inks up to $3B deal for mutant‑selective PI3Kα asset
Novartis agreed to acquire Pikavation Therapeutics for up to $3 billion to add SNV4818, a mutant‑selective PI3Kα inhibitor, to its oncology pipeline. The deal includes roughly two‑thirds of the...
Positive colorectal data sends CytomX shares on a rollercoaster
CytomX reported positive dose‑expansion data from a Phase I trial of varsetatug masetecan (varseta‑M) in metastatic colorectal cancer, prompting sharp intraday stock moves. At the 10 mg/kg dose...
Alectinib boosts CAR T efficacy in ALK‑driven neuroblastoma models
Preclinical work shows the ALK inhibitor alectinib can enhance CAR T‑cell cytotoxicity against ALK‑driven neuroblastoma, researchers report. The study details combination experiments where...
UK trial finds no extra benefit from surfactant in severe infant bronchiolitis
A UK‑led randomized clinical trial concluded that surfactant therapy provided no additional clinical advantage for infants with severe bronchiolitis who required mechanical ventilation....
Nearly one‑in‑five pediatric hospital deaths linked to sepsis — JAMA study
A national study published in JAMA estimated that nearly 20% of pediatric hospital deaths in the U.S. are associated with sepsis, providing the first standardized assessment of pediatric sepsis...
Reinforced biotubes offer off‑the‑shelf vascular graft alternative
Researchers published Nature Communications results describing reinforced biotubes as a regenerative vascular graft option designed for ready availability. The team, led by Cheng, Zhi, and...
HKUST reveals DICER’s single‑nucleotide precision in microRNA processing
A team at The Hong Kong University of Science and Technology delineated how the human enzyme DICER achieves single‑nucleotide precision when processing microRNAs, advancing mechanistic...
Acinetobacter capsule structure drives resistance and immune evasion
Researchers reported that structural variations in Acinetobacter capsules modulate both antibiotic resistance and host immune responses, shedding light on pathogenicity mechanisms of A. baumannii....
Blood–brain barrier remains leaky years after contact sports — long‑term risk signal
A study in Science Translational Medicine found that retired contact‑sport athletes showed persistent blood–brain barrier leakiness years after play, and that barrier disruption correlated with...