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Compass Pathways' Psilocybin Therapy Achieves Phase 3 Endpoint in Depression Trial
Compass Pathways reported positive outcomes from the largest-ever trial of psilocybin for treatment-resistant depression, meeting its primary endpoint of a significant reduction in depression...
Eli Lilly's Bimagrumab Enhances Fat Loss and Preserves Lean Mass with Wegovy
Data presented at the American Diabetes Association meeting showed that combining Eli Lilly's investigational drug bimagrumab with Novo Nordisk's obesity treatment Wegovy resulted in greater fat...
Closed-Loop Electrical Stimulation Stops Epileptic Seizures and Protects Memory
A novel closed-loop stimulation system was demonstrated to halt focal epilepsy progression by delivering real-time, precisely timed electrical pulses to epileptogenic brain regions upon detecting...
Advanced AI and Neural Recording Techniques Unveil Brain-Wide Primate Activity
Neuroscientists have pioneered a method enabling high-density neural recordings across the entire brain of awake nonhuman primates, integrating ultra-high-density microelectrode arrays implanted...
Reprogramming CAR T Cells In Vivo via Targeted mRNA Delivery for Cancer Therapy
Capstan Therapeutics reported data on a novel in vivo engineering approach that uses targeted lipid nanoparticles (LNPs) to deliver mRNA encoding chimeric antigen receptors (CARs) directly to...
Proteomics and Multiomics Expansion Propel Biotech Growth and Innovation
Recent corporate moves and technological advances illustrate biotechnology’s rapid expansion into proteomics and multiomics. Illumina’s acquisition of SomaLogic assets and collaborators’...
Closed-Loop Stimulation Halts Epilepsy and Safeguards Memory
Researchers have developed a novel closed-loop electrical stimulation system that interrupts focal epilepsy seizures while preserving long-term memory, as detailed in Nature Neuroscience. Unlike...
Cholinergic Neurons Mediate Brain Blood Flow and CSF Dynamics
A study published in Nature Communications reveals that basal forebrain cholinergic neurons regulate both cerebral blood flow and cerebrospinal fluid (CSF) movement. Using optogenetic activation...
Genomic Test Predicts Chemotherapy Resistance in Cancer Patients
Researchers at the Spanish National Cancer Research Centre, collaborating with Cambridge University and Tailor Bio, developed a genomic test that predicts patient resistance to standard...
Fungal-Derived Peptides from Aspergillus flavus Signal New Cancer Therapies
University of Pennsylvania scientists discovered novel ribosomally synthesized and post-translationally modified peptides (RiPPs) from Aspergillus flavus with potent activity against leukemia...
GLP-1 Drugs Redefine Weight Loss Treatments but Raise Concerns
GLP-1 receptor modulators, initially developed for diabetes, have emerged as effective weight loss therapies inducing 15-20% body weight reduction. Experts emphasize their use in conjunction with...
FDA Approves Gilead’s Twice-Yearly HIV Prevention Injection Lenacapavir
The FDA approved lenacapavir (Yeztugo) for HIV prevention, marking a milestone after decades of development. This long-acting injectable offers biannual dosing, improving adherence and prevention...
Mitochondrial Hyperactivation Identified as a Target in Aggressive Melanoma
A comprehensive proteomic study has revealed that lethal melanomas overexpress mitochondrial protein synthesis and metabolic pathways that sustain tumor growth. Targeting these pathways with...
Swedish Study Links Advanced Maternal Age to Neonatal Risks
Analysis of over 300,000 Swedish births indicates that maternal age above 40 significantly increases risks of stillbirth, prematurity, low birth weight, and neonatal hypoglycemia. Using data from...
Linköping University Advances Solar-Driven Green Hydrogen Production
Researchers developed an innovative three-layer composite material that enhances solar water splitting efficiency by eightfold, boosting sustainable green hydrogen generation. Combining cobalt...
Nrf2-HMOX1 Pathway Identified as Key to Cisplatin Resistance in Lung Cancer
A study reveals that the Nrf2-HMOX1 axis plays a central role in non-small cell lung cancer’s resistance to cisplatin by suppressing ferroptosis, a regulated form of cell death linked to...
Genomic Test Predicts Chemotherapy Resistance: CNIO and Cambridge Collaboration
Scientists at the Spanish National Cancer Research Centre (CNIO), in collaboration with the University of Cambridge and biotech startup Tailor Bio, have developed a genomic test that predicts...
Fungal-Derived Peptides Offer New Leukemia Drug Pathways
Researchers at the University of Pennsylvania have isolated novel anticancer peptides from the toxic fungus Aspergillus flavus, transforming a historically harmful microbe into a promising drug...
GLP-1 Receptor Drugs Shift Weight Loss Landscape Amid Demand Surge
GLP-1 receptor modulators, initially developed for diabetes treatment in the 1970s, have emerged as leading drugs for substantial non-surgical weight loss, achieving 15-20% reductions in body...
FDA Approves Gilead's Twice-Yearly HIV Prevention Lenacapavir
The FDA granted approval for Gilead’s lenacapavir (Yeztugo), a novel HIV prevention drug administered twice yearly, marking a significant advance in prophylactic treatment strategies. This...