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Latest Biotech News

RAS-driven resistance mechanism in pancreatic cancer: ZNF274 links lineage switch to CDK7 drug resistance

May 25, 2026

Researchers reported that ZNF274 helps drive a lineage-switch program in pancreatic cancer and, in turn, fuels resistance to CDK7-targeted therapy. The work frames ZNF274 as a regulatory node...

Liver disease stratification: spatial multi-omics maps macrophage shifts in MASLD progression

May 25, 2026

Spatial multi-omics work identified shifting macrophage populations across progression of MASLD and proposed markers that could support patient stratification in clinical trials. The study used...

Neuroscience therapy targeting: machine learning optimizes dual-target DBS for Parkinson’s

May 25, 2026

A machine-learning framework was developed to optimize deep brain stimulation (DBS) targeting both the subthalamic nucleus (STN) and substantia nigra (SN) for Parkinson’s disease. The dual-target...

Epilepsy mechanism and control: thalamo-cortical synchrony shapes temporal lobe seizure dynamics

May 25, 2026

Researchers reported that thalamo-cortical synchrony drives seizure dynamics in human temporal lobe epilepsy (TLE), reframing how seizure expression may be orchestrated across connected brain...

Oncology care economics: Canadian cost-utility analysis finds structured exercise program cost-effective in resected colon cancer

May 25, 2026

A pre-specified cost-utility analysis tied to the phase III CHALLENGE trial found that a 3-year structured exercise program (SEP) delivered both lower total costs and higher effectiveness versus...

Pregnancy: antenatal N-acetylcysteine shows promise for imminent preterm birth prevention

May 25, 2026

A randomized, placebo-controlled trial reported evidence supporting antenatal N-acetylcysteine (NAC) supplementation for pregnant women facing imminent preterm birth. The study, by Küster et al.,...

Infectious disease: C. difficile sepsis shows comparable mortality to other sepsis causes

May 25, 2026

A Scientific Reports study found that sepsis associated with Clostridioides difficile infection carries mortality risk comparable to sepsis from other causes. The finding challenges assumptions...

Wearables/biomedical devices: nanofiber self-adhesive electrode with PEDOT and polyurethane

May 25, 2026

Researchers developed a nanofiber self-adhesive electrode combining self-doped PEDOT with polyurethane, aiming to address adhesion and flexibility challenges for biomedical and wearable...

Small-cell lung cancer therapy

May 25, 2026

A multicenter randomized phase 2 study called DURABLE reported that maintenance therapy with durvalumab plus anlotinib improved outcomes versus durvalumab monotherapy in extensive-stage small-cell...

Epilepsy mechanistic neuroscience

May 25, 2026

New human research links temporal lobe seizures to thalamo-cortical synchrony, outlining how coordinated activity shapes seizure dynamics in temporal lobe epilepsy (TLE). The study frames seizure...

AI-enabled neuromodulation

May 25, 2026

Researchers reported a machine-learning framework to optimize dual-target deep brain stimulation (DBS) aimed at both the subthalamic nucleus (STN) and the substantia nigra (SN) for Parkinson’s...

Multiomics in MASLD and liver disease stratification

May 25, 2026

Spatial multi-omics profiling mapped shifting macrophage populations across MASLD progression and identified markers that could support patient stratification for clinical trials. The study...

Pancreatic cancer resistance biology

May 25, 2026

A study identified ZNF274 as a regulator of lineage switching that helps drive CDK7 drug resistance in pancreatic cancer. By connecting a lineage-plasticity mechanism to resistance against...

Prognostics in childhood aplastic anemia

May 25, 2026

Researchers developed a prognostic model for childhood aplastic anemia (AA) patients treated with cyclosporine monotherapy, aiming to address the unpredictability of response. The reported...

Treatment timeline inference in glioma

May 25, 2026

Researchers used causal machine learning to model time-dependent treatment effects of radiotherapy and chemotherapy in patients with lower-grade gliomas. The approach aims to infer treatment...

AI drug design platform advance

May 25, 2026

Isomorphic Labs previewed the Isomorphic Labs Drug Design Engine (IsoDDE), positioning it as an upgrade path beyond AlphaFold-driven structure prediction. The company claims IsoDDE more than...

AI in drug discovery and operations

May 25, 2026

Novo Nordisk said it is using AI to speed up drug launches and is expanding operations in India. The report links AI integration in discovery and development workflows to shorter time-to-launch,...

Drug development pipeline event previews

May 25, 2026

ASCO 2026 pre-meeting materials highlighted multiple data sets across gastrointestinal and genitourinary cancers that investigators and clinicians will watch. The preview specifically pointed to...

Spatial multi-omics maps macrophage shifts in MASLD

May 25, 2026

Researchers used spatial multi-omics to track how macrophage populations change across MASLD progression, pinpointing markers that may help stratify patients for clinical trials. The work focuses...

AI-powered drug design pushes beyond AlphaFold with IsoDDE

May 25, 2026

Isomorphic Labs unveiled the Drug Design Engine (IsoDDE), a computational system aimed at expanding AI small-molecule discovery beyond structure-only predictions. The company says IsoDDE more than...