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AI-driven membrane mapping accelerates cryo-ET workflows
Researchers from Helmholtz Munich, Technical University of Munich (TUM), and the University of Basel released MemBrain v2, an AI tool that automates 3D membrane mapping from cryo-electron...
AI-powered fall prediction funding signals continued appetite for digital health
Inspiren raised $70 million in Series C funding led by NewView Capital to scale its AI-powered senior living platform. The system uses ambient sensors and computer vision to predict falls before...
Checkpoint-style lung cancer strategy fails in first-line PD-L1 high disease
A Phase 3 trial testing an antibody-drug combination regimen in first-line PD-L1-high metastatic lung cancer reported a negative outcome. Sacituzumab govitecan plus pembrolizumab failed to produce...
New small-molecule strategy targets KRAS pathway limitations
A new drug-discovery wave is focusing beyond KRAS G12C, targeting broader KRAS-driven biology in cancers where the most famous mutation class has dominated the market. The coverage highlights...
Tarlatamab dosing schedule exploration in small cell lung cancer
New data on tarlatamab dosing in small cell lung cancer are focusing on whether patients can be treated with longer gaps between doses. The randomized Phase 2 DeLLphi-309 results, presented at the...
Immune-oncology biomarker and pharmacokinetics question in pembrolizumab
A translational modeling study challenges a core assumption behind PD-1 immunotherapy dosing: that receptor occupancy can predict immune activation. The analysis, published in the British Journal...
Real-world kidney outcomes for Nefecon expand beyond trials
A real-world study reported that Nefecon—targeted-release budesonide—reduced proteinuria and preserved kidney function in patients with primary IgA nephropathy. The analysis also included patients...
Vaccine immunogenicity enhancement with mRNA flu design
A study reported that an mRNA influenza vaccine design can sustain germinal centers, broadening antibody responses. The article describes how preserving these germinal center structures supports a...
Sepsis management debate: plasma transfusion evidence remains conflicting
The evidence base for plasma transfusion in neonatal sepsis remains unsettled, with a review highlighting promising theory but conflicting clinical data. The article frames plasma therapy as a...
Phase 3 oncology readout risk for SELLAS (event-driven stock impact)
SELLAS Life Sciences’ shares sold off after a sharp decline in public pricing—without a corresponding issuer filing or company update—highlighting how timing around its Phase 3 REGAL trial can...
Checkpoint inhibitor strategy stumble in PD-L1-high metastatic lung cancer
A Phase 3 trial evaluating an antibody-drug combination plus immune checkpoint inhibition delivered a clinical letdown in PD-L1-high metastatic lung cancer. Sacituzumab govitecan, an antibody-drug...
Tarlatamab dosing interval flexibility emerges in small cell lung cancer
New Phase 2 data suggest patients on tarlatamab in small cell lung cancer may be able to stretch dosing intervals without losing early activity signals. In the randomized DeLLphi-309 analysis,...
On-device oncology diagnostics: prostate staging and liquid biopsy push
A cluster of evidence is tightening the diagnostic toolbox in urologic oncology. A new review argues that liquid biopsy is becoming a non-invasive route to precision treatment decisions in bladder...
Lung cancer immunotherapy: patient-specific immune measurement shifts target identification
Researchers reported a new approach to connect biology with outcomes in lung cancer immunotherapy by using blood-based protein signatures. The work focuses on identifying who benefits from...
HIV cure research: NK cell education imprints on HIV reservoirs
New mechanistic findings in HIV cure research show that educating natural killer (NK) cells can leave lasting functional imprints on the persistent HIV reservoir. The report reframes the reservoir...
Diabetes care safety operations: monitoring older cancer patients on steroids
A new diabetes monitoring pathway is designed to keep older cancer patients safe during corticosteroid therapy, addressing the risk of steroid-driven hyperglycemia in elderly cohorts. The focus is...
CAR-T and engineered TCR advances for solid tumors
Engineered immune-cell design continues to iterate on durability and activation in solid tumors. A study reports engineered T-cell receptors with built-in ICOS signaling that may extend anti-tumor...
Reproductive and neuroimmune biology: prenatal stress linked to cognitive changes via Galectin-3
A new preclinical study ties prenatal stress to lasting cognitive impairments through brain immune signaling. Investigators report that a week of stress during pregnancy increases Galectin-3 in...
Translational imaging and AI workflow improvements: reducing pathology analysis burden
Digital pathology is getting workflow upgrades aimed at speed and standardization. A new browser-based tool for TMA de-arraying is positioned as a FAIR, low-footprint way to extract data from...
Immuno-oncology—checkpoint combinations, dosing assumptions and survival
Phase 3 IMpower030 data added a new benchmark for early-stage lung cancer immunotherapy, reporting that perioperative atezolizumab plus chemotherapy more than doubled event-free survival versus...