Latest Biotech News

UChicago Medicine has started an investigator-initiated first-in-human trial of an on-site manufactured T-cell receptor therapy targeting NY-ESO-1 in patients with advanced solid tumors. The...

Pancreatic cancer researchers identified RRM2 as a molecular link between nucleotide metabolism and lipid remodeling that drives gemcitabine resistance in pancreatic ductal adenocarcinoma. The...

Samuraciclib, an oral CDK7 inhibitor, showed improved clinical benefit when combined with fulvestrant in women with advanced HR-positive, HER2-negative breast cancer previously treated with CDK4/6...

A large Intermountain Health randomized trial published in JAMA found that starting vasopressin early in septic shock patients did not improve survival or recovery compared with waiting until the...

Postoperative circulating tumor DNA (ctDNA) may predict recurrence risk in HPV-negative head and neck squamous cell carcinoma, according to a meta-analysis of eight studies. Detectable ctDNA after...

A narrative review argues that most patients labeled penicillin-allergic are not truly allergic and that delabeling should move to routine antimicrobial stewardship using PEN-FAST and direct oral...

Rutin binds the splicing factor hnRNP L and disrupts its liquid–liquid phase separation, shifting a metabolic regulatory axis linked to pulmonary fibrosis in cell and mouse models, according to a...

Tiny hybrid micelles increased corneal delivery of the antibiotic ofloxacin, producing an eightfold higher transcorneal flux and sustained release over ten hours in ex vivo sheep cornea tests,...

A two-year implementation study at a major children’s cancer center reported that universal psychosocial screening across the pediatric cancer treatment trajectory is feasible, acceptable, and...

A prospective study in Karachi reported drug-related problems in 93% of hospitalized children with infections, while pharmacist interventions were accepted in 98.7% of cases and returned 142% on...

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) backed RevMed’s first-in-class pancreatic cancer therapy, according to an update tied to the agency’s positive...

QuantumCyte’s AI-guided digital pathology approach targets a practical bottleneck in solid-tumor genomics: low tumor-cell purity in biopsies. The method identifies tumor borders on slides and...

A pan-cancer systematic review identifies circulating protein signatures that predict outcomes to immune checkpoint inhibitors before therapy begins. Across 49 pre-treatment cohorts, the analysis...

A Chinese-developed sequencing assay using donor-derived cell-free DNA reported a threshold for detecting acute heart transplant rejection, enabling noninvasive monitoring that could reduce...

Danish researchers reported that a low-level CD19 exon 2 splice variant—detectable in pre-treatment RNA sequencing—correlates with relapse after anti-CD19 CAR-T therapy. The study links relapse...

A review argues that sepsis diagnostics are stuck less on discovering new biomarkers and more on translating candidates into certified bedside tests that fit emergency workflows. The authors...

A commentary proposes “Goldilocks zone” antibiotic prescribing for preterm infants, calling for precision stewardship that balances the risks of missed sepsis against microbiome disruption and...

A large real-world analysis among older Medicare patients compared asthma biologics and found mepolizumab performed comparably to dupilumab for preventing asthma hospitalizations. The same dataset...

An overview highlights a shift in pediatric oncology nursing workflows as AI moves from passive documentation to active safety surveillance. The report focuses on immunotherapy toxicities in...

A review spotlights copper overload as a driver of cuproptosis—a mitochondria-dependent cell death pathway—and frames it as a potential cancer vulnerability. The piece summarizes how excess copper...