Get the Daily Brief
Latest Biotech News
Neurological and Neurodegenerative Disease Research and Therapeutics
Multiple studies highlight advances in understanding and treating neurodegenerative diseases. A new activator DNL343 targets eIF2B to address ALS and TDP-43 proteinopathies. Novel gene therapies...
Stem Cell Applications in Disease and Space Research
Innovations in stem cell science continue with several breakthroughs. Tel Aviv University researchers are preparing for the first human transplant of lab-grown spinal cord stem cells aimed at...
Biomanufacturing and Industry Restructuring in Biotech and Pharma
CSL announced restructuring plans including a 15% workforce reduction and spinning off its Seqirus vaccine unit into a standalone company to improve capital efficiency and strategic focus....
Viking’s Oral Obesity Drug Faces Investor Setbacks Amid Trial Discontinuations
Viking Therapeutics recently announced phase 2 data for its oral GLP-1/GIP receptor dual agonist VK-2735, demonstrating significant weight loss of up to 12.2% over 13 weeks. Despite meeting...
PTC Therapeutics’ Friedreich’s Ataxia Drug Rejected by FDA
The FDA issued a complete response letter denying approval for PTC Therapeutics’ vatiquinone to treat Friedreich’s ataxia, citing insufficient evidence of efficacy despite positive secondary...
Novo Nordisk’s Wegovy Approved for Metabolic Fatty Liver Disease
Novo Nordisk’s GLP-1 agonist Wegovy received accelerated FDA approval to treat metabolic dysfunction-associated steatohepatitis (MASH) in adults with non-cirrhotic liver scarring. Phase 3 results...
Skyhawk Therapeutics Teams with Merck KGaA in $2 Billion RNA Drug Deal
Skyhawk Therapeutics announced a major neurology-focused collaboration with Germany’s Merck KGaA aimed at discovering RNA splicing modulators. The deal could be valued up to $2 billion and expands...
Anocca Secures $46 Million for Novel Pancreatic Cancer T-Cell Therapy Trial
Anocca AB has raised $46 million to advance its CRISPR-edited T-cell receptor (TCR) immunotherapy targeting mutant KRAS mutations in pancreatic ductal adenocarcinoma, one of the most aggressive...
Adaptive Biotechnologies and Genentech End Cancer Cell Therapy Collaboration
Adaptive Biotechnologies and Genentech announced termination of their strategic collaboration initiated in 2018 to develop personalized cancer cell therapies using T-cell receptor technologies....
AI Model Accelerates Design of Nanoparticles for RNA Therapeutics
Researchers at MIT developed COMET, a transformer-based machine learning model, to optimize lipid nanoparticle (LNP) formulations for RNA vaccine and therapy delivery. By analyzing thousands of...
Advancements in Immune and Cancer Research Reveal New Therapeutic Targets
Multiple groundbreaking studies have illuminated critical pathways and biomarkers in cancer and immunity. These include discoveries about TOPK’s role in kidney cancer immune suppression, METTL16’s...
Emerging Technologies Target Rare Diseases and Neurodegeneration
Breakthroughs in rare disease and neurodegenerative disorder therapeutics are progressing rapidly. Stealth BioTherapeutics advances its Barth syndrome drug through regulatory efforts despite prior...
AI-Accelerated RNA Therapeutics Development Gains Momentum
Cutting-edge artificial intelligence techniques are transforming RNA-based drug discovery and delivery. MIT researchers introduced a machine-learning model named COMET that accelerates the design...
CSL Restructures with Vaccine Spin-off and Workforce Cuts
Australian pharmaceutical giant CSL announced a strategic overhaul including spinning off its vaccine subsidiary, Seqirus, into a standalone entity and cutting up to 15% of its workforce. The...
Novo Nordisk Expands Wegovy Approval to Fatty Liver Disease
Novo Nordisk’s blockbuster GLP-1 agonist, Wegovy (semaglutide), gained accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), representing the first GLP-1...
Viking Therapeutics Oral Obesity Pill Faces Investor Scrutiny
Viking Therapeutics reported positive Phase 2 results for VK-2735, an oral dual GLP-1/GIP receptor agonist showing up to 12.2% weight loss after 13 weeks. However, significant gastrointestinal...
Stealth BioTherapeutics Resubmits FDA Application for Rare Disease
Stealth BioTherapeutics resubmitted its drug candidate for Barth syndrome to the FDA after an earlier rejection citing insufficient efficacy evidence. The company is pursuing regulatory engagement...
Anocca Raises $46 Million to Fund Pancreatic Cancer T-Cell Therapy Trial
Swedish biotech Anocca secured $46 million in financing to advance the clinical development of VIDAR-1, a first-in-Europe nonviral genome-edited T-cell receptor (TCR) therapy targeting mutant KRAS...
New Structural Insights Across Oncology and Immunology Target Identification
Recent studies Illuminate mechanisms underpinning cancer and immune responses. Research from Rockefeller University identified a mitochondrial antioxidant pivotal to breast cancer metastasis,...
AI and Digital Tools Enhance Mental Health and Patient Monitoring
Innovative AI-driven approaches are advancing mental health care and remote patient management. A smartphone-delivered digital therapeutic demonstrated a 50% reduction in repeated suicide attempts...