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In‑body CAR‑T: UCSF and Azalea show programmable T cells inside patients
UCSF researchers reported a dual‑vector system that achieves programmable, site‑specific integration of large DNA payloads into human T cells without ex vivo manufacturing. The team, led by Justin...
Engineered E. coli: sustained nitric oxide reprograms tumors and boosts PD‑L1 therapy
Two companion papers in Nature Biotechnology report an engineered Escherichia coli Nissle strain that produces sustained intratumoral nitric oxide (NO), reshaping the tumor microenvironment to...
FDA clears Icotyde: J&J lands oral IL‑23 pill for plaque psoriasis
The U.S. Food and Drug Administration approved Icotyde (icotrokinra), an oral IL‑23 receptor antagonist developed by Protagonist Therapeutics in partnership with Johnson & Johnson. Approval was...
Protein sequencing leaps: single‑molecule peptide decoding and scalable proteomics
Two high‑impact methods published this week promise to upend how labs read proteins. Stanford researchers detailed a scalable single‑molecule peptide sequencing approach that reverse‑translates...
Implantable charging station revives engineered immune cells – a new route to durable cell therapy
Researchers published an implantable platform that periodically 'charges' engineered immune cells in vivo, restoring function and extending anti‑tumor activity. Preclinical data show the device...
Trillion Gene Atlas: Basecamp, Anthropic and partners launch massive evolutionary data project
Basecamp Research unveiled the Trillion Gene Atlas, a coordinated effort with Anthropic, Ultima Genomics and PacBio to scale evolutionary sequencing and AI training data by orders of magnitude....
DNA Script widens global reach: SYNTAX oligo synthesis lands in Latin America and East Asia
DNA Script signed distribution agreements to place its benchtop SYNTAX platform with partners in Latin America (Gencell), South Korea (Bio‑Medical Science Co.) and Japan (BioStream). The deals aim...
FDA opens RMAT door: regenerative medicine designations for therapies on clinical hold
The FDA announced it will consider regenerative medicine advanced therapy (RMAT) designations even for experimental therapies placed on clinical hold, revising prior practice. The policy shift was...
SBIR/STTR reauthorized: Congress restores five years of seed funding for biotech startups
Congress passed a five‑year reauthorization of the SBIR and STTR programs, restoring seed‑funding pathways for small U.S. biotech companies that underpin early translational work. The...
White House lifts NIH hold: agency cleared to spend 2026 research budget
After a congressional hearing, the Office of Management and Budget approved NIH apportionments, ending a months‑long restriction that limited NIH to essential expenses. NIH Director Jay...
J&J’s psoriasis pill clears FDA: Icotyde approved
The U.S. Food and Drug Administration approved Icotyde (icotrokinra), an oral IL‑23 receptor antagonist from Johnson & Johnson and Protagonist Therapeutics, for moderate-to-severe plaque...
Basecamp’s Trillion Gene Atlas... a new evolutionary data push
Basecamp Research unveiled the Trillion Gene Atlas initiative in partnership with Anthropic, Ultima Genomics, and PacBio, aiming to expand evolutionary sequence diversity by roughly 100‑fold to...
Arvinas PROTAC shows CNS penetration: LRRK2 degraded in CSF
Arvinas reported Phase 1 multiple‑dose data for ARV‑102, a PROTAC degrader targeting LRRK2, showing approximately ≥50% reduction of LRRK2 protein in cerebrospinal fluid by day 14 that was...
In vivo CAR‑T clears tumors in mice: Azalea posts Nature paper
Azalea Therapeutics, a spinout from Jennifer Doudna’s lab, reported preclinical in vivo CAR‑T results in Nature showing that systemically delivered gene‑editing particles can reprogram host T...
DNA Script expands SYNTAX reach: distributors in Latin America and East Asia
DNA Script signed distribution agreements with Gencell, Bio‑Medical Science Co. (BMS), and BioStream to expand global access to its benchtop SYNTAX platform for on‑demand single‑strand DNA oligo...
Crossbow raises $77M to push T‑cell engagers into clinic
Crossbow Therapeutics closed a $77 million Series B co‑led by Taiho Ventures and Arkin BioCapital to advance next‑generation T cell engager programs, including lead candidate CBX‑250 developed...
White House lifts NIH spending hold: agency cleared to spend 2026 budget
The Office of Management and Budget lifted a previous apportionment restriction, allowing the National Institutes of Health to access its full 2026 appropriations and resume awarding new grants....
SBIR/STTR funding reauthorized: Congress preserves seed grants for biotech
Congress passed a five‑year reauthorization of the SBIR and STTR programs, restoring federal seed funding that many small biotech firms rely on to reach commercialization milestones. The House...
FDA will consider RMATs for therapies on clinical hold – policy shift
The FDA announced it will consider regenerative medicine advanced therapy (RMAT) designations for candidate cell and gene therapies even when those programs are under clinical hold. The procedural...
Leica, Bio‑Techne automate RNAscope on BOND‑PRIME: US launch
Leica Biosystems and Bio‑Techne announced the U.S. launch of RNAscope automation on Leica’s BOND‑PRIME staining platform, enabling fully automated RNAscope RNA in‑situ hybridization (ISH) with...