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Innovations in Cell Therapy and Gene Editing for Rare Diseases
The Chan Zuckerberg Initiative and Innovative Genomics Institute have launched the Center for Pediatric CRISPR Cures with $20 million in funding to develop personalized CRISPR-based therapies for...
Medical Advances in Obesity and Metabolic Health
Recent clinical and preclinical studies reveal progress in therapies targeting obesity and metabolic disorders. Rhythm Pharmaceuticals reported positive Phase II results for bivamelagon, an oral...
Liquid Biopsy and Microbiome RNA Modifications Advance Cancer Detection
Researchers at the University of Chicago have developed a novel liquid biopsy test detecting microbiome-derived cell-free RNA methylation modifications that predict colorectal cancer with higher...
FDA and Regulatory Developments in Drug Safety and Market Authorization
The FDA’s pediatric advisory committee voted nearly unanimously to continue post-market surveillance of 21 drugs and three vaccines, including high-profile products such as Novartis’ Entresto and...
AI and Technology Partnerships Drive Oncology Drug Discovery
Revolution Medicines and AI company Iambic Therapeutics announced a multi-year collaboration leveraging Iambic’s NeuralPLexer AI platform for protein-ligand interaction prediction to accelerate...
Addressing Biopharma Market Pressures and Layoffs
Biopharma companies experienced a 32% year-over-year increase in layoffs during the first half of 2025, with major workforce reductions reported in May and repeated adjustments by struggling firms...
Continuous and Modular Manufacturing Transform Biologics Production
The transition from traditional fed-batch to continuous manufacturing technologies is reshaping monoclonal antibody production, offering improved efficiency, scalability, and cost-effectiveness....
Gene and Cellular Mechanisms Uncovered in Plant and Metabolic Biology
Recent studies have elucidated complex genetic and cellular mechanisms underlying plant morphology, metabolism, and disease processes. A Nature publication revealed how cryptic cis-regulatory...
Merck Acquires Verona Pharma in $10B Respiratory Market Push
Merck & Co. has agreed to acquire London-based Verona Pharma for approximately $10 billion, securing rights to Ohtuvayre (ensifentrine), the first inhaled non-steroidal dual phosphodiesterase...
Center for Pediatric CRISPR Therapies Launched with $20M Funding
The Chan Zuckerberg Initiative and the Innovative Genomics Institute announced a $20 million grant to establish the Center for Pediatric CRISPR Cures. This center aims to develop personalized...
Alzheimer’s Risk Genes Mapped to Tau Spread Pathways
Scientists from UCSF and collaborators applied an extended network diffusion model to brain imaging and gene expression data from 196 individuals to understand differential vulnerability to tau...
Liquid Biopsy Using Microbial RNA Modifications Diagnoses Colorectal Cancer
Researchers at the University of Chicago developed a liquid biopsy test that analyzes modification patterns in microbiome-derived cell-free RNA in plasma to detect colorectal cancer. Utilizing...
Advances in Continuous Manufacturing Transform Biologics Production
Continuous bioprocessing technologies, such as the XCell ATF system adopted by Enzene Biosciences, are improving monoclonal antibody manufacturing by enabling higher productivity, reduced costs,...
ProKidney’s Cell Therapy Shows Dose-Dependent Kidney Function Benefits in Phase 2
ProKidney's autologous cell therapy rilparencel demonstrated a significant reduction in kidney function decline by 78% in one cohort of diabetic chronic kidney disease patients. Another cohort...
Jasper Therapeutics Slashes Workforce After Drug Trial Setbacks
Following disappointing clinical trial results with its KIT-targeting antibody briquilimab, Jasper Therapeutics is reducing its staff by approximately 50%. The clinical failures included loss of...
Actithera Raises $75M Series A to Advance Radiopharmaceutical Oncology Pipeline
Radiopharmaceutical biotech Actithera closed a $75.5 million Series A round, despite operating as a single-person company during fundraising. The financing will support clinical development of...
Liquid Biopsy and AI Tools Advance Cancer and Genetic Disease Research
Quanterix completed the acquisition of Akoya Biosciences for $127 million, integrating spatial biology and tissue testing technologies to streamline liquid biopsy biomarker discovery and...
Endometriosis Diagnosis Via Salivary MicroRNA Shows Promise
Researchers led by Sofiane Bendifallah developed a non-invasive diagnostic approach for endometriosis using salivary microRNA signatures. This method may overcome the diagnostic delay associated...
Merck Expands Respiratory Pipeline: $10 Billion Verona Acquisition
Merck & Co. has agreed to acquire London-based Verona Pharma for approximately $10 billion, marking its largest deal since 2023. Verona's FDA-approved inhaled drug Ohtuvayre (ensifentrine) is...
Liquid Biopsy Breakthrough: Microbiome RNA Marks Colorectal Cancer
Researchers at the University of Chicago developed a new liquid biopsy test detecting colorectal cancer through methylation modifications in microbiome-derived cell-free RNA in plasma. Utilizing...