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Phase II data and leadership exit – Cardiff shares halve in two days
Cardiff Oncology reported positive Phase II data for onvansertib in RAS-mutated metastatic colorectal cancer while simultaneously announcing the departures of its CEO and CFO. The twin disclosures...
Thermo Fisher shutters Mass. site: layoffs exceed 100
Thermo Fisher Scientific filed notice that it will close its Franklin, Massachusetts facility and lay off more than 100 employees, according to a state filing. The company attributed the move to...
AbbVie bets on precision immunology: reverse translation to guide combos
In a perspective piece, Kori Wallace, AbbVie’s VP of Clinical Development for Immunology, outlines a strategic shift toward precision immunology built on reverse translation and rational...
Lentiviral vectors take center stage in next‑gen gene therapies
A recent study reviewed advances in lentiviral-vector technology that are reshaping gene-therapy delivery, highlighting improvements in tropism, payload capacity, and safety profiling. Authors...
In vivo CARs move closer to clinic – new reagents and protocols emerge
Researchers outlined progress in in vivo CAR therapeutic development, describing delivery strategies (viral vectors, nanoparticles), CRISPR editing needs, and assay frameworks for assessing CAR...
Brown uncovers molecular switch to sensitize glioblastoma to therapy
Brown University scientists published a Cell Reports study that decodes a molecular mechanism limiting glioblastoma response to existing therapies and identifies a targetable pathway to enhance...
FDA Halts Regenxbio Trials: Cancer Case Prompts Clinical Hold
The FDA placed clinical holds on two Regenxbio gene therapy studies after a participant in one study developed cancer, raising fresh safety and regulatory questions for viral-vector programs....
EU Overhauls Rules: Generics and Biosimilars Could Come Sooner
European regulators will implement new laws that tighten the pathways companies use to delay generic and biosimilar competition, forcing drugmakers to navigate additional regulatory steps to...
Thermo Fisher Shutters Mass. Site: 100+ Employees Affected
Thermo Fisher Scientific announced the closure of its Franklin, Massachusetts facility, triggering layoffs for more than 100 employees according to a state notice. The company cited site...
Neoadjuvant FOLFIRINOX–Nivolumab: Pilot Phase 1 Yields Promising Signals in PDAC
A pilot phase 1 trial evaluated neoadjuvant modified FOLFIRINOX combined with nivolumab in pancreatic ductal adenocarcinoma (PDAC) and reported encouraging safety and preliminary activity,...
Brown Identifies Pathway to Sensitize Glioblastoma to Therapy
Researchers at Brown University disclosed a molecular mechanism that could enhance therapeutic responses in glioblastoma, offering a potential pathway to overcome intratumoral resistance, the team...
Intranasal H5N1 Vaccine Prevents Infection in Rodents — WashU Study
Washington University researchers developed an intranasal adenoviral-vectored H5N1 vaccine that protected mice and hamsters from highly pathogenic avian influenza in preclinical testing, the team...
University of Ottawa Launches OMARI: Medical AI Hub Established
The University of Ottawa inaugurated the Ottawa Medical Artificial Intelligence Research Institute (OMARI) to centralize medical-AI research, led by Dr. Khaled El Emam, Canada Research Chair in...
Machine Learning Tool Maps Scope of Paper-Mill Fraud in Cancer Science
Researchers at Queensland developed a machine‑learning tool that identifies suspicious publications and mapped a broad spread of likely paper‑mill outputs affecting cancer research literature. The...
C‑Suite Shakeup and Data Release Send Cardiff Stock Down 45%
Cardiff Oncology reported positive Phase II signals for onvansertib in RAS‑mutated metastatic colorectal cancer while simultaneously announcing the resignations of CEO Mark Erlander and CFO James...
In vivo CARs: New Reagent Suites Target Translation Bottlenecks
An industry-focused review outlined practical steps to advance in vivo CAR approaches from concept to clinical translation and highlighted commercial reagent solutions aimed at de‑risking the...
FDA halts Regenxbio trials: cancer case triggers clinical holds
The FDA placed clinical holds on two Regenxbio gene‑therapy studies after a participant developed cancer, raising fresh safety questions for adeno‑associated virus (AAV) and related viral vector...
Thermo Fisher shutters Franklin lab — more than 100 layoffs
Thermo Fisher Scientific announced the closure of its Franklin, Massachusetts facility and notified state regulators of workforce reductions affecting over 100 employees. The company filed a...
Cardiff leadership exit: shares plunge after Phase II update
Cardiff Oncology disclosed positive Phase II data for onvansertib in RAS‑mutated metastatic colorectal cancer at the same time its CEO and CFO resigned, prompting a sharp market reaction and a...
Nasal H5N1 vaccine prevents infection in rodents: WashU reports
Washington University School of Medicine reported an intranasal adenoviral‑vectored H5N1 vaccine that protected hamsters and mice from highly pathogenic avian influenza strains and remained...