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Breakthrough in Cancer CAR-T Therapy Shows Promising Clinical Results
Johnson and Johnson report encouraging phase 1b trial data for their dual-targeting CAR-T therapy in relapsed/refractory large B-cell lymphoma. Among patients with one prior treatment, a 100%...
Advances in AI-Driven Spatial Transcriptomics Resource Released
Northwestern University released SOAR, an expansive spatial transcriptomics platform aggregating over 3,400 samples across species and tissue types to enable comprehensive cell-cell interaction...
Sarepta Pauses Duchenne Gene Therapy After Second Patient Death
Sarepta Therapeutics halted shipping its Duchenne muscular dystrophy gene therapy, Elevidys, for non-ambulatory patients after a second death due to acute liver failure. The company is working on...
J&J Reports 100% Response Rate in Early Dual-Antigen CAR-T Trial
Johnson & Johnson revealed data from a phase 1b trial showing 100% objective response in relapsed/refractory large B-cell lymphoma patients with one prior therapy following treatment with a dual...
Sarepta Pauses Duchenne Gene Therapy After Second Patient Death
Sarepta Therapeutics halted shipping its Duchenne muscular dystrophy gene therapy, Elevidys, for non-ambulatory patients after a second death due to acute liver failure. The company is working on...
Gene Therapy Safety Hit: Sarepta Pauses Duchenne Drug
Sarepta Therapeutics has suspended shipments of its Duchenne muscular dystrophy gene therapy, Elevidys, for non-ambulatory patients following a second death linked to acute liver failure. Both...
Parkinson’s Diagnostics: Nerve Fiber and Perivascular Biomarkers
Recent studies highlight novel Parkinson's disease biomarkers derived from peripheral and brain vasculature. One cohort study published in npj Parkinson’s Disease revealed pathological changes in...
Rapid Vascular Organoid Formation via Transcription Factor Control
A new method enables swift generation of functional vascular organoids from human stem cells by simultaneous activation of endothelial and mural lineage transcription factors. Published in Cell...
AI and Multiomics Fusion: Proteomics Integration Drives Biology Forward
Innovations in multiomics propel biology into integrative analyses combining genomics, transcriptomics, and proteomics. Collaborations between sequencing firms and proteomics companies have...
FDA Greenlights Pembrolizumab for Resectable Head and Neck Cancer
Pembrolizumab has received FDA approval for resectable locally advanced head and neck squamous cell carcinoma expressing PD-L1 (CPS ≥1), marking the first checkpoint inhibitor approved for...
23andMe Assets Acquired by Anne Wojcicki's Nonprofit Amid Bidding
Anne Wojcicki, co-founder and former CEO of 23andMe, through her nonprofit TTAM Research Institute, won a $305 million bid to acquire most of 23andMe's assets. The win overturned a prior Regeneron...
Novo Nordisk Advances Dual GLP-1, Amylin Obesity Drug to Late Trials
Novo Nordisk plans phase 3 clinical studies for amycretin, a dual GLP-1 and amylin receptor agonist, targeting overweight and obesity. Early trials showed significant weight loss with both...
Advanced CAR-T Data: J&J Sees High Response in Dual-Target Trial
Johnson & Johnson disclosed promising early data from its dual CD19/CD20-targeting CAR-T program in relapsed/refractory large B-cell lymphoma. Among patients with one prior therapy, objective...
Biotech Bill Prioritizes R&D and Patient Affordability Strategies
The US budget reconciliation bill includes pivotal biotech provisions supporting innovation and patient access. Key components involve the ORPHAN Cures Act fixing rare disease drug exemptions in...
Peripheral Nerve Fiber Research Advances Parkinson’s Diagnosis
A landmark cohort study published in npj Parkinson’s Disease reveals that pathological changes in skin-accessible cutaneous nerve fibers provide novel insights into Parkinson’s disease and...
Novo Nordisk Initiates Phase 3 Trials for Next-Gen Obesity Drug Amycretin
Novo Nordisk advances its obesity pipeline by planning late-stage clinical trials for amycretin, a dual GLP-1 and amylin receptor agonist. Following promising phase 2 data indicating substantial...
ADC Therapeutics Cuts Workforce, Closes UK R&D Site Amid Setbacks
ADC Therapeutics announced a 30% workforce reduction and the closure of its UK R&D facility after halting development of multiple preclinical and clinical candidates due to limited efficacy and...
Magnetic Soft Millirobot Enables Simultaneous Mobility and Sensing
A research team led by W. Zeng and colleagues has developed a magnetic soft millirobot that can both navigate and sense environmental variables simultaneously. Utilizing a polymer matrix with...
Parkinson’s Disease: Novel Insights into Peripheral Nerve Fiber Changes
Recent cohort studies published in npj Parkinson’s Disease reveal key alterations in cutaneous nerve fibers in Parkinson’s disease (PD) and atypical parkinsonism. Using immunohistochemical...
FDA Approves Pembrolizumab for Locally Advanced Head and Neck Cancer
The U.S. Food and Drug Administration has approved pembrolizumab for patients with resectable locally advanced head and neck squamous cell carcinoma expressing PD-L1 (CPS ≥1). This marks the first...