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Gilead expands real-world data and AI collaboration with Tempus
Gilead expanded its Tempus partnership, granting the drugmaker broader access to Tempus’s multimodal real-world cancer dataset library and its AI platform. Tempus said the multi-year collaboration...
Gilead pays for molecular glue degrader option from Kymera
Gilead agreed to pay Kymera Therapeutics $45 million to exercise an option on a preclinical anticancer molecular glue degrader, adding another oncology asset to a pipeline built through...
Neuroblastoma target points to nNOS–mTOR axis for therapy development
Researchers from The Hebrew University of Jerusalem reported that blocking neuronal nitric oxide synthase (nNOS) suppresses neuroblastoma growth by disrupting an AKT–TSC–mTOR signaling cascade....
Precision nasal oxytocin and controlled delivery technologies enter mental health/neurology space
Insilico-accelerated drug discovery aside, one clinically oriented delivery theme that emerged in the dataset is long-term intranasal oxytocin work aimed at stabilizing exposure beyond short-lived...
Neuroinflammation and cardiac fibrosis via engineered dendritic cells
A preclinical report described engineered dendritic cells that prevent cardiac remodeling, targeting the fibrotic processes that drive progression to heart failure. The approach is positioned...
Grail and Epic expand ordering of early cancer blood test inside EHR workflows
Grail partnered with Epic to integrate access to the Galleri multi-cancer early detection test directly within Epic electronic health record platforms. Under the agreement, clinicians can order...
Sidewinder Therapeutics raises $137M for precision bispecific ADCs
Sidewinder Therapeutics emerged from stealth with an oversubscribed $137 million Series B, backed by investors including OrbiMed and Novartis’ venture arm. The San Diego biotech is developing...
Neurocrine to acquire Soleno for $2.9B, expands rare endocrinology portfolio
Neurocrine Biosciences agreed to acquire Soleno Therapeutics for $2.9 billion in cash, a deal designed to scale a marketed therapy for Prader-Willi syndrome. The transaction includes Soleno’s...
Targeted degradation partnerships
Roche has entered the antibody-targeted protein degrader space by expanding its C4 Therapeutics collaboration, committing $20 million upfront for two oncology targets and more than $1 billion in...
ADC funding and platform scale-up
Sidewinder Therapeutics emerged from stealth with an oversubscribed $137 million Series B, pitching a bispecific ADC approach designed to improve tumor targeting while reducing toxicities. The San...
ADC mega-deals at Gilead
Gilead agreed to acquire ADC specialist Tubulis in a deal valued at up to $5 billion, following multiple large transactions since late February. The acquisition includes $3.15 billion upfront plus...
Pulmonary fibrosis IPO for inhaled reformulations
Avalyn Pharma filed for an IPO to fund late-stage development of inhaled reformulations of approved pulmonary fibrosis drugs. The Cambridge-based company plans to move AP01 (inhaled pirfenidone)...
Immunology targeting BCDa2 in cutaneous lupus
Biogen strengthened the clinical case for BDCA2 as a therapeutic target in cutaneous lupus erythematosus after a second Phase II success for litifilimab (an investigational anti-BDCA2 therapy)....
Oncology translational models
Dynamic42 and EPO (Experimental Pharmacology and Oncology) announced a collaboration to bring organ-on-chip platforms earlier into preclinical glioblastoma workflows. The partners will pair...
Neurodegeneration and precision biomarkers via genomics
23andMe reported new genetic findings tied to outcomes and side effects from GLP-1 receptor agonist therapies. In a Nature study, investigators analyzed 27,885 research-consented participants and...
Hospital workflow integration for multi-cancer early detection
Grail expanded access to its Galleri multi-cancer early detection test by partnering with Epic to integrate test ordering directly into Epic’s electronic health record workflows. Clinicians using...
Corporate consolidation in rare-disease endocrinology
Neurocrine agreed to acquire Soleno Therapeutics for $2.9 billion, expanding its commercial portfolio in endocrinology and rare disease. The deal includes cash consideration of $53.00 per share,...
Clinical program setback in advanced pancreatic cancer
Amplia Therapeutics halted enrollment in its Phase II Amplicity trial for advanced pancreatic cancer after three dose-limiting toxicities tied to the modified FOLFIRINOX regimen combined with...
M&A surge reshapes oncology and platform capabilities
Gilead Sciences has agreed to acquire German ADC specialist Tubulis for up to $5 billion, seeking to expand its antibody-drug conjugate platform with new linker and payload technologies. The deal...
European VC capital: Jeito closes a larger biopharma fund for clinical-stage bets
Jeito Capital, a prominent European biopharma investor, closed its second independent fund at more than €1 billion (about $1.2 billion), topping its target and raising the firm’s AUM to €1.6...