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Precision oncology diagnostics consolidation
Tempus AI agreed to buy Personalis for $1.5 billion, stepping deeper into minimal residual disease (MRD) testing and expanding its tumor-informed liquid biopsy portfolio. Under the deal terms,...
AI infrastructure bets by Big Pharma
Bristol Myers Squibb and Nvidia said they will expand pharma’s AI compute footprint, targeting “the most powerful AI factory in life sciences.” BMS plans to build new infrastructure around an...
Gene-editing in vector research
Researchers reported the world’s first gene-edited biting midges (Culicoides), opening a new path for studying how these vectors transmit livestock diseases. The advance targets Culicoides, small...
Early signals of praziquantel resistance
A new whole-genome study identified early genomic indicators that Schistosoma mansoni may be developing reduced sensitivity to praziquantel, the sole widely used drug for schistosomiasis control....
Pan-cancer tumor organoid platform for precision testing
Researchers published a pan-cancer patient-derived organoid (PDO) platform designed for precision oncology modeling and therapeutic vulnerability screening. In Science Advances, the team described...
Alzheimer’s and tau pathology target discovery
Sanford Burnham Prebys researchers reported that upregulating SORLA suppresses multiple pathological features in an aged mouse model of tauopathy. In Science Advances, the team tied the...
Non-opioid pain pipeline move toward late-stage testing
Latigo Biotherapeutics disclosed IPO plans to fund development of its oral Nav1.8 inhibitor LTG-001, positioning the program for late-stage expansion in acute and broader post-surgical and...
Clinical trial translation: implementation science in CRO workflows
A new analysis argued that implementation science training should become a core capability for clinical trial workforces to improve how evidence translates into routine healthcare. The study...
Machine learning accuracy fix for genomics
University of Virginia researchers identified a widespread source of error in a popular genomics method and created a free machine-learning tool to correct it. The work, described as improving...
Cell therapy manufacturing scalability focus
A new perspective focused on scalable cell therapy manufacturing argues that developers should shift from research workflows to GMP-ready systems earlier in development. The article emphasizes...
Precision oncology diagnostics deals
Tempus AI agreed to acquire cancer test-maker Personalis for about $1.5 billion, marking a decisive consolidation push in minimal residual disease (MRD) testing. The deal pairs Personalis’s...
Cancer modeling and functional screens using patient organoids
Researchers published a pan-cancer patient-derived organoid (PDO) platform in Science Advances that claims high fidelity to the original tumors and yields actionable therapeutic vulnerabilities....
Neurodegeneration biology and target discovery
Scientists at Sanford Burnham Prebys reported in Science Advances that SORLA upregulation suppressed multiple pathological features in an aged tauopathy mouse model. The study centers on tau...
Biomarker discovery using blood proteomics
A plasma proteomics study identified protein patterns linked to Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal dementia, reporting a 21-protein panel for distinguishing...
Regulatory risk and portfolio pressure in CAR-T competition
Legend Biotech’s shares fell about 10% despite reporting record Carvykti sales, after remarks on a Johnson & Johnson earnings call drew investor concern. J&J’s Worldwide Chair of Innovative...
Cell and gene therapy scaling discussion: in vivo CAR T
Researchers and clinicians debated delivery constraints for in vivo CAR T therapeutics at BIO Asia–Taiwan 2026, positioning in vivo CAR T as a potential “second revolution” in cell and gene...
Neurobiology of memory stabilization in adolescence
A study from Albert Einstein College of Medicine, published in PLOS Biology, links late-adolescent brain remodeling in mice to temporary instability in contextual memory circuits. The work centers...
Genetic risk to dementia diagnostics: blood to clinic translation
Preclinical and translational discussions in oncology aside, a dedicated investigation addressed how blood plasma protein signatures can correspond to distinct neurodegenerative dementia...
Corporate AI infrastructure for drug discovery
Bristol Myers Squibb and Nvidia said they will expand AI infrastructure to build what BMS calls the “most powerful” AI factory in life sciences. The company plans to deploy Nvidia DGX SuperPOD...
Regulatory approval and new oral PCSK9 therapy
Merck KGaA’s Lipfendra became the first oral PCSK9 inhibitor approved by the FDA for lowering LDL cholesterol in adults with high cholesterol. The approval advances a new delivery approach for...