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Cancer Immunity: Microbiota’s Role Post-Radiotherapy
New research highlights how the gut microbiota modulates immune responses following radiotherapy, influencing cancer treatment outcomes. This evolving understanding reveals that microbiome...
GSK's Major Licensing Deal With Hengrui Pharma Expands COPD Pipeline
GlaxoSmithKline has entered a landmark agreement with Jiangsu Hengrui Pharmaceuticals, paying $500 million upfront for rights to the experimental COPD drug HRS-9821 along with options on 11...
Abivax Surge on Phase III Ulcerative Colitis Data and $747M Offering
Abivax's shares soared after reporting positive Phase III trial results for its oral ulcerative colitis drug obefazimod, triggering massive investor demand that expanded its offering to nearly...
FDA Rejects Replimune’s RP1 Oncolytic Virus, Signaling Regulatory Shift
The FDA issued a complete response letter for Replimune’s RP1 oncolytic virus therapy, causing its stock to plunge by 75%. Despite promising Phase II data showing response rates surpassing...
FDA Investigates Death Linked to Sarepta’s Elevidys Duchenne Therapy
The FDA is probing the death of an 8-year-old Brazilian boy who had received Sarepta Therapeutics’ Elevidys gene therapy for Duchenne muscular dystrophy. Shipment of Elevidys has been voluntarily...
Mass Ivermectin Use Reduces Malaria Transmission in Kenya Trial
A large-scale cluster-randomized trial in Kwale, Kenya, demonstrated that mass administration of ivermectin to children aged 5–15 reduced new malaria infections by 26% beyond standard bed net use....
Mitophagy Pathways Uncovered: New Therapeutic Avenues for Parkinson’s
Researchers at the University of Vienna have delineated molecular mechanisms by which transmembrane cargo receptors initiate mitophagy, a selective autophagy process important in Parkinson’s...
AI's Role in Pharma Real-World Data Insights Faces Regulatory and Usability Tests
Although generative AI (GenAI) generates excitement in healthcare analytics, life sciences companies require platforms that offer data agnosticism, transparency, and regulatory compliance to...
Neuromodulation and Microbiome Therapies Show Promise in Parkinson’s
Recent advances in Parkinson’s disease research include theta-frequency deep brain stimulation (DBS) enhancing conflict resolution and a pilot study demonstrating the safety of fecal microbiota...
Emerging Guidelines and Therapeutic Targets Revamp Hematology and Oncology
New clinical guidelines from the European Hematology Association and European Myeloma Network are transforming care for smoldering multiple myeloma, emphasizing risk stratification and early...
Microbial and Plant Immunity Mechanisms Drive Agricultural and Biological Innovations
Frontline research has unveiled mechanisms such as a root-based N-hydroxypipecolic acid circuit regulating Arabidopsis immunity and growth, and complex genetic bases of sorghum mold resistance...
FDA Rejection Rocks Replimune’s Oncolytic Virus Program
The FDA’s recent complete response letter to Replimune’s RP1 oncolytic virus therapy marks a pivotal regulatory setback, signaling a stricter era for oncology drug approvals. RP1, engineered with...
Ivermectin Mass Drug Administration Cuts Malaria Infections in Kenya
A landmark cluster-randomized trial in Kwale, Kenya, demonstrated that monthly mass administration of ivermectin to children aged 5–15 reduced new malaria infections by 26%, supplementing existing...
New Pathways Illuminate Mitophagy Initiation in Parkinson’s Disease
University of Vienna researchers decoded molecular mechanisms of mitophagy initiation via transmembrane cargo receptors BNIP3 and NIX, unveiling hierarchical flexibility in autophagy machinery....
Abivax Soars on Phase III Ulcerative Colitis Success and $747 Million Offering
Abivax shares surged dramatically after Phase III results for obefazimod, an oral ulcerative colitis drug, exceeded expectations, catalyzing a heavily oversubscribed U.S. offering initially set at...
FDA Probes Death Linked to Sarepta’s Duchenne Gene Therapy Elevidys
The FDA is investigating the June 7 death of an 8-year-old Brazilian boy receiving Sarepta’s Duchenne muscular dystrophy gene therapy Elevidys amid voluntary shipment suspensions. Sarepta and...
Bipartisan Bill Pushes Medicare Advantage Payment Parity with Traditional Medicare
U.S. legislators introduced the Prompt and Fair Pay Act mandating that Medicare Advantage plans reimburse providers at rates equal to traditional Medicare and expedite claim payments. This...
Selective Estrogen Receptor Degrader Vepdegestrant Outshines Fulvestrant in Breast Cancer
New data reveal that vepdegestrant, a PROTAC-based selective estrogen receptor degrader, demonstrates superior efficacy over fulvestrant in advanced ER-positive, HER2-negative breast cancer...
Microbiota’s Influence Emerges in Radiotherapy-Driven Cancer Immunity
Recent research highlights the critical role of the gut microbiome in shaping antitumor immune responses elicited by radiotherapy. Modulations in microbiota composition affect tumor...
Agrivoltaics Enhances Photosynthesis Mitigating Dryland Heat Stress
A study published in npj Sustainable Agriculture demonstrates that integrating photovoltaic solar panels with crop cultivation (agrivoltaics) alleviates midday photosynthetic depression in dryland...