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Obesity pipeline: retatrutide safety/tolerability details
Eli Lilly disclosed additional safety and tolerability data for retatrutide at the American Diabetes Association meeting, including counts of arrhythmias and major cardiovascular complications...
Obesity competition: Roche obesity combo trial starting
Roche plans to initiate a Phase 2 trial combining petrelintide and enicepatide later this year, according to ADA26 reporting. The companies are positioning the dual-incretin approach as a path to...
Obesity competition: Pfizer monthly berobenatide data
Pfizer presented updated clinical data supporting monthly dosing of berobenatide for obesity, following earlier signals from VESPER-3. In the study, patients transitioned from weekly dosing to...
Obesity pipeline validation: Pfizer’s berobenatide in obesity and diabetes
At ADA26, Pfizer added additional framing for berobenatide’s use in obesity and diabetes, citing data presented alongside its long-acting GLP-1 receptor agonist program. The coverage also ties the...
Company finance: Ona raises $86.6M
Ona secured an $86.6 million venture round positioned among Spain’s largest biotech financings, according to Biocentury Finance reporting. The capital injection underscores continued appetite for...
M&A/strategy: Forbion brings in Novo business development leader
Forbion announced the hire of John McDonald as an operating partner focused on business development and M&A, with prior experience including corporate business development leadership at Novo...
Oncology tools: first-in-human ADC development expands
An early first-in-human study is underway for ABBV-706, a SEZ6-targeting antibody-drug conjugate (ADC), in patients with advanced solid tumors. The program’s Journal of Clinical Oncology...
ADC pipeline: SYS6043 Phase 1 dose escalation
SYS6043, a B7-H3/Top1 antibody-drug conjugate (ADC), began Phase 1 dose escalation in solid tumor malignancies, according to the study listing. The start of dose escalation highlights ongoing...
Diagnostics & infectious disease: portable CRISPR assay for mpox
Researchers engineered a portable CRISPR-based assay for mpox detection in the wake of the 2025 outbreak in Sierra Leone, as described in the report. The approach is aimed at field diagnostics and...
Obesity pharmacology: new retatrutide safety/tolerability updates
Eli Lilly disclosed additional safety and tolerability data for retatrutide at the American Diabetes Association meeting and in The Lancet, extending results from TRANSCEND-T2D-1. The company...
Monthly GLP-1/analogs: Pfizer’s berobenatide data reinforce dosing cadence
Pfizer reinforced its obesity and diabetes case for berobenatide with new mid-stage results presented at ADA and reported by STAT+. In the VESPER-3 study, patients transitioned from weekly dosing...
Ebola diagnostics: WHO scales point-of-care molecular testing plan
The World Health Organization unveiled a six-month plan to stamp out the current Bundibugyo Ebola virus outbreak in Africa, including a major scale-up of point-of-care molecular diagnostics. WHO...
Clinical pipeline: Roche moves to Phase 2 on obesity combo petrelintide and enicepatide
Roche said it will start a Phase 2 trial combining petrelintide and enicepatide this year, targeting obesity with an eye toward differentiating safety and efficacy across its amylin-based program....
ADC momentum: first-in-human antibody–drug conjugate readouts at ASCO
Antibody–drug conjugates headlined first-in-human development at ASCO, according to BioCentury’s analysis of 137 FIH studies highlighted at the meeting. The review found that ADCs accounted for...
Genetics-to-immunology: germinal center “noise” yields reliable antibody evolution
A Cell study led by Gabriel D. Victora at The Rockefeller University tracked thousands of B cells across more than 100 germinal centers in mice and found the process of affinity improvement is far...
Oncology therapeutics research: MSX1 identified as tumor promoter in cervical cancer
Researchers in Cell Death Discovery reported that the transcription factor MSX1 plays a tumor-promoting role in cervical cancer. The study, published June 5, 2026, described new molecular...
Neurodegeneration mechanism: microglial CD31 blocks Aβ clearance in Alzheimer’s model
A study in preclinical Alzheimer’s research reported that microglial CD31 hinders amyloid-beta clearance and worsens pathology in a 5×FAD mouse model. The work identified CD31 as a critical...
Company restructuring: Fulcrum cuts most staff after discontinuing sickle cell program
Fulcrum Therapeutics said it is laying off 85% of staff after discontinuing development of its lead sickle cell disease candidate, citing an FDA decision that left “no viable regulatory path.” The...
AI in life sciences ops: Medable launches agentic AI program for clinical development workflows
Medable launched an Agentic Accelerator Program to help life sciences companies deploy agentic AI across clinical development. The offering includes onboarding, integration support, governance,...
Obesity and diabetes late-stage safety updates
Eli Lilly reported additional safety and tolerability data for retatrutide, its next-generation obesity drug, in disclosures tied to the TRANSCEND-T2D-1 late-stage program. At the American...