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Idiopathic pulmonary fibrosis funding and next-phase trial
Celea Therapeutics, a PureTech Health spinout, secured $180 million to support a pivotal Phase 3 program for idiopathic pulmonary fibrosis (IPF) using deupirfenidone, an oral small-molecule...
Ulcerative colitis Phase 3 maintenance readout stabilizes investor view of Abivax
Abivax shares rebounded after the company reported additional positive efficacy from the ABTECT Maintenance Part 2 supplemental portion of its Phase 3 ulcerative colitis (UC) program for...
Personalized dendritic-cell vaccination enters clinical spotlight in glioblastoma
A personalized neoantigen dendritic cell vaccine approach for newly diagnosed glioblastoma delivered promising Phase Ib signals in a study published in Nature Communications. The trial evaluated...
AI model COMPASS targets response prediction for immune checkpoint inhibitors
Harvard Medical School researchers led by Marinka Zitnik unveiled COMPASS, an AI model designed to predict patient response to immune checkpoint inhibitors (ICIs). The approach is framed as...
Clinical informatics: NLP outperforms ICD-10 coding for clinical data capture
Research described in the excerpt reports that natural language processing (NLP) tools can outperform ICD-10 coding systems at capturing clinically relevant information. The work suggests NLP can...
Organ engineering and liver regeneration research, revisited through MIT’s Sangeeta Bhatia
In an updated profile, MIT biomedical engineer Sangeeta Bhatia discussed how her Bio-MEMS and liver research have evolved over the past 13 years, including work tied to infectious disease and...
Complement biology: C5aR2 signaling mechanisms clarified
Researchers have published work clarifying the molecular underpinnings of C5aR2, a complement receptor implicated in inflammatory responses downstream of the anaphylatoxin C5a. The excerpt...
AI-assisted clinical workflow risks: evidence of medical ‘deskilling’ with decision support
A study summarized in the excerpt describes evidence that clinicians’ performance can decline when AI decision-support tools are unavailable, illustrating a potential “deskilling” risk in...
Non-pharmacologic Parkinson’s adjunct: vibrotactile sternum pilot trial
A randomized, double-blind, placebo-controlled pilot trial reported in npj Parkinson’s Disease explored a sternum-worn vibrotactile device as an adjunct for Parkinson’s disease. The excerpt...
Translational sensing for engineered heart tissue monitoring
An international research team including the University of Tokyo developed a biomechanical sensor inspired by the lateral line organ in fish to measure pulse in lab-grown 3D heart tissue (cardiac...
IPF drug development and large financing for late-stage trial
Celea Therapeutics secured $180M to run a pivotal Phase 3 head-to-head study for deupirfenidone in idiopathic pulmonary fibrosis (IPF), targeting a pivotal readout for a potentially differentiated...
Personalized cell therapy in newly diagnosed glioblastoma
Researchers reported promising Phase Ib clinical trial results for a personalized neoantigen dendritic cell vaccine in newly diagnosed glioblastoma, according to a study published in Nature...
AI for predicting responses to cancer immunotherapy
A new AI model called COMPASS, developed by researchers at Harvard Medical School led by Marinka Zitnik, was reported to improve prediction of patient response to immune checkpoint inhibitors...
Diagnostic coding and NLP accuracy versus ICD-10
New research found that natural language processing (NLP) tools can outperform ICD-10 coding for capturing clinically relevant information, shifting attention toward extracting meaning directly...
Immune biology target discovery in complement signaling
Researchers detailed unique signaling behavior of C5aR2, a complement receptor that appears to depart from classic receptor signaling patterns, with the findings emerging from work focused on how...
Clinical engineering: vibrotactile device for Parkinson’s
A pilot randomized, double-blind, placebo-controlled trial published in npj Parkinson’s Disease reported positive findings for a sternum-worn vibrotactile device used as a non-pharmacological...
Translational neuroscience: linking working memory to consciousness
Researchers explored how working memory could contribute to consciousness, framing working memory as the information needed to complete tasks in the moment and proposing it may be closely entwined...
Cellular metabolism and epigenetic regulation via lysine pyruvylation
A study in Nature Metabolism reported lysine pyruvylation (Kpy) as a post-translational modification that links glycolysis-derived pyruvate metabolism to epigenetic regulation. The work describes...
Biophysics tool for measuring cardiac organoid pulse
An international team, including the University of Tokyo, developed a sensor inspired by the fish lateral line that measures pulse in lab-grown 3D heart tissue (cardiac organoids). The device,...
Preclinical translational signal: AI-assisted detection in biomedical imaging contexts
Researchers trained AI models on more than 120,000 images of salmon lice larvae and found the systems were faster and more accurate than experienced biologists at identifying the parasites. While...