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Fecal microbiota transplantation explored beyond C. difficile for broad therapeutic potential
Fecal microbiota transplantation (FMT), originally validated for recurrent Clostridioides difficile infection, is gaining investigation across diverse conditions including alopecia, depression,...
Urgency in pharma drives data integration to resolve speed-trust paradox in decision making
Pharmaceutical organizations face mounting pressure to accelerate drug development while maintaining regulatory trust and patient safety. Despite digital investments, fragmented data systems...
AstraZeneca’s $1.3B Bet Pays Off: Baxdrostat’s Phase 3 Win in Hypertension
AstraZeneca announced positive phase 3 results for baxdrostat, a blood pressure drug acquired from CinCor Pharma. In a late-stage trial with 796 patients suffering uncontrolled hypertension,...
Mitochondrial NAD+ Pools Crucial in Aging Cell Metabolism
New research from the University of Bergen reveals that mitochondrial nicotinamide adenine dinucleotide (NAD+) pools are critical in cellular aging. Employing a model of constitutive NAD+...
Wildfire Smoke Elevates Cardiovascular Events and Mortality in Northern California
A study by Kaiser Permanente cardiology researchers linked wildfire smoke exposure to increased cardiovascular hospitalizations and mortality. Analysis of over 3 million adults during 2018...
Genetic Variability Influences Tumor Response to Immunotherapy
A collaborative study at The Jackson Laboratory employed genetically diverse mouse models to elucidate how inherited variation affects tumor response to immune checkpoint inhibitors. Their...
Repligen and Univercells Integrate Real-Time Monitoring for Viral Vector Manufacturing
Repligen has partnered with Univercells Technologies to integrate MAVEN® glucose and lactate real-time monitoring into scale-X bioreactors for adherent cell culture. This process analytical...
Proteomic Study Uncovers Widespread Misfolded Proteins in Alzheimer’s Model
Johns Hopkins researchers using limited proteolysis mass spectrometry identified over 200 types of misfolded proteins associated with age-related cognitive decline in rats, suggesting amyloid-beta...
Synaptic Plasticity Control via Cypin and K63-Linked Polyubiquitination Unveiled
Rutgers University scientists discovered that the neuronal protein cypin regulates synaptic protein content through modulation of K63-linked polyubiquitination. This process affects proteasome...
Brain Myelin Temporarily Depletes After Marathon Running but Recovers
A study involving MRI scans of marathon runners documented significant short-term decreases in myelin water fraction, a proxy for myelin content, in key white matter regions immediately post-race....
FDA Publishes Over 200 Drug Rejection Letters to Enhance Transparency
The FDA released more than 200 complete response letters (CRLs) as part of efforts to modernize and increase transparency in drug regulatory communications. While this step represents a...
Aging Cells Regulate NAD+ via Mitochondria to Maintain Metabolism
Research from the University of Bergen details how aging cells manage declining nicotinamide adenine dinucleotide (NAD+) levels through mitochondrial pools. Using a chronic depletion model, the...
Wildfire Smoke Tied to Elevated Cardiovascular Risks in California
A study analyzing Northern California's 2018 wildfires revealed significant increases in cardiovascular hospitalizations and mortality during dense smoke exposure from the Mendocino Complex fire....
Marathon Running Temporarily Alters Brain Myelin Structure
University of the Basque Country neuroscientists documented that marathon runners experience short-term reductions in brain myelin content, especially in white matter tracts critical for...
Genetic Diversity Influences Tumor Immunotherapy Outcomes in Mice
Researchers at The Jackson Laboratory employed genetically diverse Collaborative Cross mice to dissect how inherited variability affects tumor response to immune checkpoint inhibitors. Their...
FDA Publishes Drug Rejection Letters Amid Transparency Push
The FDA released over 200 complete response letters as part of efforts to increase transparency in its drug review process. However, the agency imposed limitations on the scope of disclosures....
Rutgers Study Links Synaptic Protein Modification to Brain Plasticity
A Rutgers-led team identified the protein cypin as a regulator of K63-linked polyubiquitination, modulating synaptic protein composition in mice. This post-translational modification influences...
Identification of Extensive Misfolded Proteins in Aging Brain
Johns Hopkins researchers used limited proteolysis mass spectrometry to detect over 200 misfolded proteins potentially linked to age-related cognitive decline in rats. This expands the scope...
Repligen-Univercells Alliance Brings Real-Time Viral Vector Monitoring
Univercells Technologies partnered with Repligen to integrate MAVEN® Real Time Glucose Control within scale-X bioreactors, enabling continuous, nondestructive monitoring of glucose and lactate...
Fecal Microbiota Transplants Expand Beyond Infection to Neurological Disorders
Fecal microbiota transplantation (FMT), originally endorsed for treating recurrent C. difficile infections, is rapidly diversifying into research on allergies, neurodegenerative diseases,...