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Regulatory approvals and gene therapy incentives
FDA approved Rocket Pharmaceuticals’ gene therapy Kresladi (marne-cel) for leukocyte adhesion deficiency type I, the company said, adding a rare pediatric disease priority review voucher to the...
Oncology checkpoint inhibitor combinations
A phase II GETNE-DUTHY trial is evaluating durvalumab plus tremelimumab in advanced thyroid cancer, according to the new report describing the study led by Capdevila, Hernando, and Molina-Cerillo....
Biomarkers and imaging for ovarian cancer response prediction
Researchers report that whole-body diffusion-weighted MRI (WB-DWI/MRI) can predict outcomes after neoadjuvant chemotherapy for advanced ovarian cancer, in work published in the British Journal of...
Diabetes care in older adults using real-world safety data
A Nature Communications study provides real-world comparative safety evidence for second-line antihyperglycemic agents in elderly patients with type 2 diabetes, led by Kim, Bu, Blacketer, and...
Immunotherapy resistance mechanisms in colorectal cancer
Researchers report that circulating glycocholic acid (GCA) can modulate the efficacy of immune checkpoint therapy in colorectal cancer, in a study positioned as identifying a key biochemical...
Regimen risk signals after targeted therapy and transplant in mantle cell lymphoma
A report on clinical outcomes and risks after post-ibrutinib transplant addresses how relapsed or refractory mantle cell lymphoma patients fare once they move from targeted therapy to...
Biomarkers for endocrine resistance in breast cancer
A British Journal of Cancer study describes how targetable markers define antiprogestin-resistant breast cancer, focusing on endocrine resistance in luminal disease. The work, dated April 4, 2026,...
Wearable biosensing for cardiovascular monitoring
Researchers unveiled an ultra-flexible near-infrared vertical cavity surface emitting laser (VCSEL) aimed at improving skin-friendly photoplethysmography (PPG) monitoring, with details published...
Clinical informatics methods for multi-institution EHR research
A new study proposes representation learning to advance multi-institution electronic health record (EHR) studies across the United States and France, led by Zhou, Tong, and Wang. The approach is...
Biopharma finance and funding for clinical-stage companies
A finance report highlights Ambrosia and Syneron moving toward the clinic with nine-digit Series B rounds, positioning the funding to support late preclinical or early clinical execution. The...
FDA gene therapy approval and pediatric voucher catalyst
FDA has approved Rocket Pharmaceuticals’ gene therapy Kresladi (marne-cel), targeting leukocyte adhesion deficiency type I, according to an FDA March approvals update from Rocket. The company said...
Pivotal immunotherapy signals in solid tumors
A phase II GETNE-DUTHY study is advancing a new combination approach for advanced thyroid cancer using checkpoint blockade with durvalumab and tremelimumab. The trial is led by Capdevila,...
Epigenetic reactivation strategy in AML
Researchers at The Jackson Laboratory (JAX) reported that an epigenetic strategy can restore tumor suppressor activity in acute myeloid leukemia models. In a Science Translational Medicine paper,...
Bioengineering platform for fast-acting covalent protein drugs
A Westlake University team disclosed a high-throughput engineering platform aimed at creating fast-acting covalent protein therapeutics. The approach, published in Science, describes a selection...
Targeted nanomedicine aimed at overcoming colon cancer resistance
Researchers engineered an iRGD-PLGA nanocomplex designed to target colon cancer drug resistance. The platform combines iRGD tumor-targeting behavior with PLGA delivery chemistry and is positioned...
Precision imaging and computational tools for cancer prediction
New imaging research points to whole-body diffusion-weighted MRI as a predictive tool after neoadjuvant chemotherapy for advanced ovarian cancer. In a British Journal of Cancer study, the...
Cardiometabolic and kidney-targeted drug delivery concepts
A new urea-activated nanocarrier concept is targeting sodium-glucose cotransporter 2 (SGLT2) inhibition with a site-specific approach designed for metabolic and kidney health. The study describes...
Pediatric hemostasis innovation to reduce infant surgery bleeding
Biomedical engineers at UNC-Chapel Hill and North Carolina State University reported development of an injectable microgel intended to reduce bleeding in infants undergoing surgery. In Science...
Clinical evidence on diabetes drug safety in older adults
A real-world evidence study in Nature Communications compared the safety of second-line antihyperglycemic agents in older adults with type 2 diabetes mellitus. Kim, Bu, Blacketer, and colleagues...
Oncology-targeted biomarkers and resistant disease mapping
Breast cancer research is highlighting targetable biology in endocrine-resistant disease. A British Journal of Cancer report dated April 4, 2026 identifies molecular profiles that define...