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Immunotherapy efficacy signal in microsatellite-high gastric/esophageal cancer
At AACR Annual Meeting 2026, researchers reported cohort 2 data from the single-arm INFINITY phase II trial testing tremelimumab plus durvalumab as an organ-preserving option in resectable...
Cell therapy platform engineering for B-cell lymphoma
A newly published study in Engineering lays out glycocalyx engineering strategies to improve adoptive cell therapies targeting B-cell lymphoma. The paper focuses on overcoming recurring...
New cancer biomarker model—spatial predictors for MSS mCRC
Researchers reported spatial predictors that delineate response to chemo-immunotherapy in microsatellite stable (MSS) metastatic colorectal cancer. The study’s core claim is that mapping features...
Oncology drug resistance mechanism in KRAS G12C therapy
A 2026 study described the acquired resistance pathway to KRAS G12C inhibitors in non-small cell lung cancer, identifying the AURKA/PHB2 signaling axis as a central driver. The authors reported...
Biosciences research tooling—AI microscopy in live cells
Engineers at the University of California San Diego introduced an AI-enhanced microscopy approach designed for crisp, real-time imaging inside live cells. The report says the system produces...
Policy and research funding shock—NSF National Science Board ousted
Multiple sources report that the Trump administration dismissed the entire National Science Board (NSB), which advises the president and Congress on the National Science Foundation (NSF). The...
Diagnostic AI in cardiology—smart finger cuff algorithm accuracy
A new smart finger cuff algorithm for detecting aortic stenosis demonstrated high accuracy for identifying moderate-to-severe disease in African American patients, according to results presented...
Discovery and platform—orthotopic lung model maps tumor location effects on immunity
Researchers at VIB and VUB unveiled an orthotopic lung adenocarcinoma model paired with advanced single-cell sequencing to map the immune microenvironment in lung tumors. The study focuses on how...
FDA psychedelics push via priority vouchers
President Trump signed an executive order directing the FDA and other federal agencies to accelerate research and improve access to psychedelic drugs for serious mental illnesses, using...
WHO prequalification expands antimalarial access for infants
The World Health Organization has prequalified Coartem Baby, Novartis’ antimalarial combination for infants, in a milestone that expands WHO-recognized treatment options for younger children. The...
Checkpoint blockade combination supports organ preservation in MSI-H GC
Durvalumab (Imfinzi) combined with tremelimumab (Imjudo) produced high survival and deep response signals in cohort 2 of the INFINITY phase 2 trial in resectable microsatellite instability-high...
Cell therapy platform aims to engineer glycocalyx for B-lymphoma adoptive therapy
A new paper in Engineering outlines advances in live-cell glycocalyx engineering to improve adoptive cell therapies for B-cell lymphoma. The work frames glycocalyx optimization as a way to address...
CAR-neutrophils are engineered for glioma in vivo
Researchers reported progress toward direct genetic programming of neutrophils for glioma by developing in vivo CAR-neutrophils. The approach targets a key historical barrier: neutrophils have...
Regulatory science and trial design: synthetic control arms reshape evidence generation
An Innovation Spotlight argues that synthetic control arms—generated from external datasets instead of traditional placebo groups—are changing how investigators plan clinical trials. The piece...
AI microscopy captures sharper real-time movies in live cells
Engineers at the University of California San Diego developed an AI-enhanced microscopy workflow that produces images with twice the sharpness of conventional microscopes while capturing at video...
Diagnostics: smart finger-cuff algorithm finds moderate-to-severe aortic stenosis with high accuracy
A study presented at SCAI 2026 Scientific Sessions and the CAIC-ACCI Summit in Montreal reported high-accuracy performance of a smart finger-cuff algorithm for detecting moderate-to-severe aortic...
Epigenetic vulnerability: KMT2C/D loss creates targetable cancer weaknesses
Researchers reported that loss of the epigenetic regulators KMT2C/D creates targetable vulnerabilities in cancer. The work connects tumor dependency to COMPASS-related biology, focusing on how...
Innovative TB readout: deep learning estimates Mtb antibiotic resistance and treatment response
A deep learning framework using convolutional neural networks (CNNs) was reported to quantify Mycobacterium tuberculosis antibiotic resistance and predict patient responses to treatment. The...
Psychedelic drug acceleration via White House executive action
President Donald Trump signed Executive Order 14401, directing the FDA and other federal agencies to accelerate research and expand access for psychedelic drugs intended to treat serious mental...
WHO prequalification advances infant antimalarial access
The World Health Organization has prequalified Coartem Baby, Novartis’ antimalarial combination medicine for infants. Novartis developed the product in partnership with Medicines for Malaria...