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Mitochondrial Metabolism Drives Colorectal Cancer Drug Resistance
Emerging evidence highlights mitochondrial metabolic reprogramming as a key mechanism enabling colorectal cancer cells to resist chemotherapy and targeted therapies. Tumors adapt through...
Omega Fatty Acid Profiling Breakthrough Benefits Disease Research
Researchers have developed an innovative technique enabling the comprehensive characterization of omega fatty acids, overcoming previous biochemical challenges. This advancement facilitates...
Neuroprosthetics Enable Gut Motility and Metabolism Control
A cutting-edge gastrointestinal neuroprosthesis interfacing with the enteric nervous system has been developed to modulate gut motility and metabolic functions through precise neuromodulation....
Al–Salen Catalyst Advances Enantioselective Photocyclization Chemistry
Scientists have introduced an aluminum-salen (Al–salen) catalyst that enables enantioselective photocyclization via energy transfer mechanisms. This pioneering work grants unprecedented...
Novartis Wins Phase 3 Trials in Sjögren's Syndrome – Regulatory Plans Set
Novartis announced successful results from two phase 3 trials of ianalumab, targeting BAFF-R in patients with Sjögren's syndrome. Both Neptunus 1 and 2 studies met their primary endpoints, showing...
Sarepta Addresses Patient Deaths in Elevidys Reports – FDA Data Reviewed
Sarepta Therapeutics clarified that two patient deaths reported in the FDA Adverse Event Reporting System (FAERS) related to Elevidys, its gene therapy for Duchenne muscular dystrophy, were...
Vinay Prasad Returns to Lead FDA’s CBER Amid Controversy
In an unexpected development, Dr. Vinay Prasad has resumed leadership of the FDA’s Center for Biologics Evaluation and Research (CBER) shortly after stepping down. The Department of Health and...
Microbiome Link to Fibromyalgia Evidence Emerges from Mouse Studies
New research using germ-free mice demonstrates a causative role of gut microbiota in fibromyalgia-like chronic pain. Transferring fecal samples from fibromyalgia patients induced systemic pain...
AI Advances Enable Cross-Vendor Diagnostic Imaging Collaboration
A novel framework employing federated learning has been developed to address challenges in cross-vendor medical imaging collaboration while preserving patient data privacy. Published in 2025, this...
Novel Nanoparticles Target Multiple Tumor Neoantigens for Immunotherapy
A cutting-edge platform utilizing multi-epitope ligand-conjugated nanoparticles (MELNs) has been introduced to improve precision tumor targeting in cancer immunotherapy. By conjugating diverse...
Bioelectronic Neuroprosthetics Enhance Gut Motility and Metabolism
Researchers have developed a novel gastrointestinal neuroprosthesis designed to interface directly with the enteric nervous system, enabling precise neuromodulation of gut motility and metabolic...
Childhood Lupus Nephritis Biomarkers Identified Through Bioinformatics
Recent bioinformatics studies have uncovered key molecular biomarkers, including otoferlin, which distinguish childhood-onset systemic lupus erythematosus (cSLE) from adult-onset forms and...
Advances in Battery and Energy Storage Materials Drive Efficiency
Innovations in energy storage have been realized through novel material enhancements. Carbon-coated zinc molybdenum oxide (Zn3Mo2O9) achieves improved lithium-ion battery capacity and stability,...
Emerging Evidence Links Immune Checkpoint Inhibitors to Cardiac Inflammation
Immune checkpoint inhibitors (ICIs), transformative in oncology, are increasingly implicated in serious cardiac adverse events including myocarditis and pericarditis. These immune-related...
FDA Requests Vinay Prasad’s Return Amid Controversy
Vinay Prasad has reversed his abrupt departure and is set to resume leadership at the FDA's Center for Biologics Evaluation and Research (CBER), responsible for vaccine and gene therapy oversight....
Sarepta Clarifies Patient Deaths Are Unrelated to Elevidys Therapy
Sarepta Therapeutics addressed reports of two patient deaths listed on the FDA Adverse Event Reporting System associated with Elevidys, its gene therapy for Duchenne muscular dystrophy. The...
Gut Microbiome Implicated in Fibromyalgia Pain in Rodent Models
Recent research at McGill University and the Israel Institute of Technology demonstrated that fecal microbiota transplantation from fibromyalgia patients to germ-free mice induces chronic...
Cancer Incidence Rising Among Younger Adults — Industry Response
Healthcare stakeholders are responding to increasing cancer diagnoses in younger populations by advocating for earlier screenings and improved testing accessibility. Innovations range from at-home...
AI Advances Transform Diagnostic Imaging and Stroke Care
Cutting-edge artificial intelligence applications are revolutionizing medical imaging, exemplified by DeepISLES—a deep learning model validated for enhanced ischemic stroke lesion segmentation....
New Biomarkers and Mechanisms in Cancer Progression and Treatment Resistance
Emerging molecular and metabolic insights reveal drivers of tumor progression and therapeutic evasion. Studies identify circulating Hsp70 as an early marker of thoracic cancer metastasis, while...