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Mitochondrial Hyperactivation Drives Melanoma Aggressiveness – Antibiotics Show Promise
A proteomic study analyzing 151 tumor and normal samples has uncovered that aggressive melanomas exhibit hyperactivation of mitochondrial protein synthesis and metabolic pathways fueling tumor...
Linköping University Advances Solar-Powered Green Hydrogen Yield
Researchers at Linköping University crafted a novel three-layer composite material integrating Ni(OH)2, Co3O4, and cubic silicon carbide (3C-SiC) that enhances photocatalytic water splitting...
Recycled Plastics Leach Chemicals Disrupting Hormones and Metabolism
A collaborative study between University of Gothenburg and Leipzig researchers revealed that recycled polyethylene pellets release over 80 different chemicals into water, some acting as endocrine...
Advanced Maternal Age Correlates with Elevated Neonatal Risks in Large Swedish Cohort
An extensive study of over 300,000 Swedish births from 2010 to 2022 assessed neonatal outcomes relative to maternal age beyond 35. Findings show that mothers aged 45+ face notably increased risks...
Career-Defining Advances: New TRIDs Restore Protein Function in Fanconi Anemia
Researchers announced development of translational read-through-inducing drugs (TRIDs) capable of bypassing premature stop codons caused by nonsense mutations in Fanconi anemia genes. These small...
FDA Office Shakeup Spurs Cell and Gene Therapy Market Uncertainty
Recent administrative leave placements of Nicole Verdun, MD, and deputy Rachael Anatol, PhD, from the FDA’s Office of Therapeutic Products (OTP) have reignited concerns over cell and gene therapy...
Caris Life Sciences Raises $494M in IPO for Cancer AI Tools
Caris Life Sciences recently completed a $494 million IPO, marking a significant financial milestone amid a general freeze on biopharma initial public offerings. The company applies artificial...
FDA Leadership Shakeup Sparks Gene Therapy Stock Declines
The FDA's Office of Therapeutic Products witnessed abrupt senior staff changes, including the administrative leave of Nicole Verdun, MD, and deputy Rachael Anatol, PhD. Verdun was instrumental in...
Nrf2-HMOX1 Axis Identified as Target to Overcome Lung Cancer Drug Resistance
New research has highlighted the Nrf2-HMOX1 signaling pathway as a key mediator of cisplatin resistance in non-small cell lung cancer (NSCLC). By suppressing ferroptosis, a form of regulated cell...
Novel TRIDs Offer Breakthrough in Treating Fanconi Anemia Mutations
Researchers have developed translational read-through-inducing drugs (TRIDs) designed to counteract nonsense mutations in Fanconi anemia patients. These drugs facilitate ribosomal bypass of...
AI Platform Diagnoses Vocal Cord Paralysis Severity Using Deep Learning
A pioneering artificial intelligence system employing convolutional neural networks and Mel-spectrogram analysis can accurately assess severity in unilateral vocal cord paralysis. This...
Gasdermin E Promotes Resistance and Progression in Glioblastoma
New findings reveal that Gasdermin E, known for mediating pyroptosis, paradoxically aids glioblastoma cells in evading this inflammatory cell death. Instead of triggering tumor suppression, GSDME...
Racial Disparities Found in Neonatal Hypoxic-Ischemic Encephalopathy Outcomes
A comprehensive study revealed significant racial disparities in incidence, severity, and treatment outcomes of neonatal hypoxic-ischemic encephalopathy (HIE) in the US. Black and Hispanic infants...
Tokyo Researchers Innovate Label-Free Detection for Aged Human Cells
Scientists at Tokyo Metropolitan University have introduced a label-free technique using frequency-modulated dielectrophoresis to differentiate senescent human cells. This alternating electric...
Restricted Humeral Rotation Heightens Rotator Cuff Strain in Biomechanics Study
An in vitro analysis demonstrated that limiting humeral rotation markedly increases strain on the supraspinatus and infraspinatus muscles during shoulder abduction. The research, conducted using...
Predictive Model Identifies Risk Factors for Pediatric Plastic Bronchitis
A novel scoring system and nomogram were developed to predict plastic bronchitis occurrence in children with severe Mycoplasma pneumoniae pneumonia. Based on a retrospective cohort of 416...
FDA leadership shake-up rattles cell and gene therapy stocks
The FDA has placed Nicole Verdun, MD, former super office director of the Office of Therapeutic Products at CBER, and her deputy Rachael Anatol, PhD, on administrative leave, stirring concerns...
Vertex Diabetes Cell Therapy Shows Durable Insulin Independence
Vertex Pharmaceuticals reported promising data from its investigational stem cell therapy for type 1 diabetes at the ADA conference, with 10 of 12 participants achieving insulin independence a...
Novo Nordisk’s amylin analog delivers notable weight loss with dosing questions
Novo Nordisk unveiled Phase 1/2 trial results for amycretin, an amylin-targeting obesity drug, showing substantial weight reduction across doses but with overlapping efficacy curves. The study...
AI advances reduce cost and boost clinical data automation in healthcare
Intermountain Health has adopted Layer Health's AI engine to automate clinical data abstraction across multiple patient registries, enhancing data capture efficiency. Simultaneously, OpenAI's...