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Omega Funds closes $647 million life sciences fund amid funding doldrums
Boston and Geneva-based life sciences investor Omega Funds announced the final close of its eighth fund at $647 million, matching the size of its 2021 vehicle. Despite a biotech venture capital...
Sarepta shares plunge after third gene therapy patient death
Sarepta Therapeutics’ stock dropped 36% following news of a third patient death linked to its gene therapy programs. The most recent fatality occurred in a 51-year-old participant in the Phase I...
AI and antibody engineering unite in Chugai-Gero aging therapies deal
Chugai Pharmaceutical of Japan has signed a research and licensing agreement with AI-focused biotech Gero PTE of Singapore to develop therapies targeting age-related diseases. The partnership...
FDA grants RMAT to Genascence’s gene therapy for osteoarthritis
Genascence's GNSC-001 gene therapy received Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA. The therapy uses a recombinant adeno-associated viral vector to deliver an...
Oxford Nanopore reports 25% revenue surge, fueled by applied markets
Oxford Nanopore Technologies posted preliminary H1 2025 revenues of approximately £105 million, up 25% from the same period last year and exceeding company expectations. Growth was driven by both...
Novel polygenic risk score predicts adult obesity in early childhood
An international research consortium developed a polygenic risk score (PGS) based on genetic data from over five million people capable of predicting a child's likelihood of developing adult...
Emerging manufacturing advances for scaling AAV gene therapies
The field of adeno-associated virus (AAV)-based gene therapy is rapidly expanding beyond rare diseases to address more prevalent conditions such as cardiovascular and neurological disorders. This...
Alkermes’ Narcolepsy Drug Moves Forward with Mid-Stage Success
Alkermes announced that its oral drug alixorexton significantly improved wakefulness and reduced daytime sleepiness in patients with narcolepsy type 1 during a Phase 2 clinical trial. While only...
Sarepta Shares Plunge After Third Gene Therapy Patient Dies
Sarepta Therapeutics faced a 36% stock drop following the death of a third patient treated with its gene therapies for muscular dystrophies. The latest fatality involved a 51-year-old man with...
FDA Panelists’ Anti-Antidepressant Bias Surfaces Ahead of Review
A recent Food and Drug Administration panel on antidepressant use during pregnancy featured several members with longstanding skepticism toward SSRIs. These experts have published work linking the...
Hookipa Pharma Announces Liquidation After Asset Sales to Gilead
Hookipa Pharma declared plans to delist from Nasdaq and liquidate following the sale of its vaccine assets to Gilead Sciences. The immunotherapy biotech cited lack of revenue-generating products...
Advanced PCR Automation Targets Diagnostic Workflow Bottlenecks
Seegene introduced its CURECA system, a fully automated, end-to-end PCR platform designed to eliminate manual workflow interruptions in molecular diagnostics. CURECA integrates all steps from...
Biosimilar Competition Sharpens as Stelara Faces Multiple Challengers
Johnson & Johnson’s autoimmune drug Stelara (ustekinumab) is encountering biosimilar competition from seven approved products with deep price discounts. Unlike the Humira biosimilar market,...
Gene Therapy Manufacturing Faces Scale-Up Challenges and Solutions
The market for adeno-associated virus (AAV) gene therapies is expanding toward treatments for common diseases like Alzheimer’s and cardiovascular conditions. This growth demands scalable,...
Click Chemistry Enables Targeted, Safer Cancer Therapy in Humans
For the first time, click chemistry — a Nobel-recognized technology — has been used clinically to direct chemotherapy agents specifically to tumors, minimizing systemic toxicity. This...
New Phylogenetic Analysis Redraws Transposon Regulatory Landscape
Researchers from Kyoto University and McGill University employed phylogenetic methods to better classify endogenous retrovirus subfamilies within transposable elements (TEs), which comprise nearly...
Researchers Engineer Bacteria to Produce Animal-Free Milk Proteins
Scientists have successfully genetically modified E. coli bacteria to synthesize key milk proteins essential for cheese and yogurt production, enabling dairy-free products with molecular...
AAV Gene Therapy Manufacturing Scale-Up: De-Risking Production Challenges
The AAV gene therapy field is scaling beyond rare genetic diseases to address larger patient populations including cardiovascular and neurological conditions like Alzheimer’s and Parkinson’s....
Stelara Biosimilars Race: Pricing and Interchangeability Factors
With 88 biologics facing exclusivity loss, Stelara biosimilars are under scrutiny as manufacturers compete for market share in autoimmune diseases. Stelara, J&J's top seller in 2024 with $10.4...
CMS Medicare Proposal Sparks Provider Concerns Over Physician Payments
CMS proposed a 2.4% payment boost for outpatient hospital departments and ambulatory surgery centers in 2026 alongside a two-tiered physician reimbursement framework tied to value-based care...