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Nrf2-HMOX1 Axis Identified as Target to Overcome Lung Cancer Drug Resistance
New research has highlighted the Nrf2-HMOX1 signaling pathway as a key mediator of cisplatin resistance in non-small cell lung cancer (NSCLC). By suppressing ferroptosis, a form of regulated cell...
Novel TRIDs Offer Breakthrough in Treating Fanconi Anemia Mutations
Researchers have developed translational read-through-inducing drugs (TRIDs) designed to counteract nonsense mutations in Fanconi anemia patients. These drugs facilitate ribosomal bypass of...
AI Platform Diagnoses Vocal Cord Paralysis Severity Using Deep Learning
A pioneering artificial intelligence system employing convolutional neural networks and Mel-spectrogram analysis can accurately assess severity in unilateral vocal cord paralysis. This...
Gasdermin E Promotes Resistance and Progression in Glioblastoma
New findings reveal that Gasdermin E, known for mediating pyroptosis, paradoxically aids glioblastoma cells in evading this inflammatory cell death. Instead of triggering tumor suppression, GSDME...
Racial Disparities Found in Neonatal Hypoxic-Ischemic Encephalopathy Outcomes
A comprehensive study revealed significant racial disparities in incidence, severity, and treatment outcomes of neonatal hypoxic-ischemic encephalopathy (HIE) in the US. Black and Hispanic infants...
Tokyo Researchers Innovate Label-Free Detection for Aged Human Cells
Scientists at Tokyo Metropolitan University have introduced a label-free technique using frequency-modulated dielectrophoresis to differentiate senescent human cells. This alternating electric...
Restricted Humeral Rotation Heightens Rotator Cuff Strain in Biomechanics Study
An in vitro analysis demonstrated that limiting humeral rotation markedly increases strain on the supraspinatus and infraspinatus muscles during shoulder abduction. The research, conducted using...
Predictive Model Identifies Risk Factors for Pediatric Plastic Bronchitis
A novel scoring system and nomogram were developed to predict plastic bronchitis occurrence in children with severe Mycoplasma pneumoniae pneumonia. Based on a retrospective cohort of 416...
FDA leadership shake-up rattles cell and gene therapy stocks
The FDA has placed Nicole Verdun, MD, former super office director of the Office of Therapeutic Products at CBER, and her deputy Rachael Anatol, PhD, on administrative leave, stirring concerns...
Vertex Diabetes Cell Therapy Shows Durable Insulin Independence
Vertex Pharmaceuticals reported promising data from its investigational stem cell therapy for type 1 diabetes at the ADA conference, with 10 of 12 participants achieving insulin independence a...
Novo Nordisk’s amylin analog delivers notable weight loss with dosing questions
Novo Nordisk unveiled Phase 1/2 trial results for amycretin, an amylin-targeting obesity drug, showing substantial weight reduction across doses but with overlapping efficacy curves. The study...
AI advances reduce cost and boost clinical data automation in healthcare
Intermountain Health has adopted Layer Health's AI engine to automate clinical data abstraction across multiple patient registries, enhancing data capture efficiency. Simultaneously, OpenAI's...
New translational read-through drugs offer hope for Fanconi anemia therapy
A recent study published in Cell Death Discovery detailed novel translational read-through-inducing drugs (TRIDs) designed to counter nonsense mutations in Fanconi anemia—a genetic disorder of DNA...
Mechanistic insights reveal immune cardiotoxicity risks from checkpoint inhibitors
A landmark study from the Spanish National Center for Cardiovascular Research elucidated immune system alterations that predict cardiotoxic events in cancer patients treated with immune checkpoint...
Pyroptosis regulator Gasdermin E confers resistance and tumor growth in glioblastoma
New research reveals a paradoxical function of Gasdermin E (GSDME) in glioblastoma, where it mediates resistance to pyroptosis, an inflammatory cell death pathway, while promoting tumor...
Emerging biology of Parkinson’s—nigral volume loss and α-synuclein aggregation mechanisms
Recent studies published in npj Parkinson’s Disease detail progressive nigral volume loss across prodromal to moderate disease phases using advanced MRI techniques, pinpointing potential early...
Innovations in biomedical devices: vocal cord paralysis AI and ultrathin ion membranes
Breakthroughs in biomedical engineering emerged with the development of TripleConvNet, an AI diagnostic platform using Mel-spectrograms and CNNs to objectively assess unilateral vocal cord...
Ethnic disparities in neonatal hypoxic outcomes and cancer survivors’ Alzheimer’s risk
A new epidemiological study in the Journal of Perinatology uncovered significant racial disparities in neonatal hypoxic-ischemic encephalopathy incidence, severity, and outcomes in the U.S., with...
FDA Shakes Up Cell and Gene Therapy Leadership – Market Reacts
The FDA’s Office of Therapeutic Products at CBER experienced a sudden shakeup as super office director Nicole Verdun, MD, and deputy Rachael Anatol, PhD, were placed on administrative leave. This...
Vertex’s Stem Cell Therapy for Type 1 Diabetes Gains Momentum
Vertex Pharmaceuticals updated clinical data from their investigational stem cell therapy for type 1 diabetes, revealing that 10 of 12 patients discontinued insulin use a year post-infusion. The...