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Innovative Genomic Platform Boosts Multi-Cancer Early Detection
Wholomics, a startup leveraging metabolic, lipidomic, and lipoproteomic serum signatures via a nuclear magnetic resonance platform, presents promising multi-cancer detection capabilities. Early...
DNA-Based Genetic Dimmer Switch Controls Embryonic Gene Timing
Researchers at the MRC London Institute of Medical Sciences identified a novel cis-regulatory DNA element functioning as an attenuator that precisely modulates the temporal expression of Cdx2, a...
Protein Engineering Breakthrough: Precise Codon Expansion via RNA Editing
Scientists at Peking University devised a novel RNA codon expansion platform that installs programmable pseudouridine modifications into mRNA codons to enable precise incorporation of noncanonical...
Van Andel Discovery Pinpoints PTGIR as Immune Checkpoint in Cancer
A study published in Nature Immunology by Van Andel Institute and collaborators reveals prostacyclin receptor PTGIR as a novel immune checkpoint that regulates CD8+ T cell exhaustion within the...
Major FDA Regulator’s Intervention in KalVista Review Stirs Controversy
Multiple sources report that FDA Commissioner Marty Makary sought to influence the agency’s review process by advocating for rejection of KalVista Pharmaceuticals’ investigational rare disease...
Vetter Breaks Ground on $285M Clinical Manufacturing Hub in Illinois
Contract Development and Manufacturing Organization (CDMO) Vetter commenced construction on a new clinical manufacturing site in Des Plaines, Illinois, with an investment of approximately $285...
New Organ Chip Model Predicts Chemotherapy Outcomes in Esophageal Cancer
A novel precision oncology platform has been developed to forecast chemotherapy responses in esophageal adenocarcinoma (EAC) patients, addressing the high rate of chemoresistance in this lethal...
Qiagen Expands Clinical Digital PCR Menu via Partnership Program
Qiagen has launched an open partnership initiative to broaden its in vitro diagnostic assay offerings for the QiAcuityDx clinical digital PCR system. The program invites diagnostic developers and...
FDA Drops Safety Monitoring for CAR-T Therapies to Expand Patient Access
The U.S. Food and Drug Administration (FDA) has eliminated the Risk Evaluation and Mitigation Strategies (REMS) safety monitoring requirements for all approved CAR-T cell therapies. This...
Alphabet’s Calico Signs $596M Deal for Mabwell’s IL-11 Therapeutic Program
Calico Life Sciences, backed by Alphabet, has secured exclusive global rights (outside China) to Mabwell Bioscience’s IL-11 targeting monoclonal antibody 9MW3811 in a deal worth up to $596 million...
St. Jude's ColdBrew Algorithm Illuminates Water's Role in Drug Design
Researchers at St. Jude Children’s Research Hospital have developed ColdBrew, a novel computational algorithm that more accurately models the presence and behavior of water molecules within...
New Genetic Dimmer Switch Discovered Regulating Embryonic Development Gene Cdx2
Scientists at the MRC London Institute of Medical Sciences have identified a novel DNA element functioning as a temporal 'dimmer switch' that precisely attenuates expression of the critical...
Plus Therapeutics Set to Relaunch CNSide Test for Central Nervous System Cancer
Plus Therapeutics plans to relaunch the CNSide cerebrospinal fluid assay, a diagnostic test for leptomeningeal metastases in the central nervous system (CNS), which detects circulating tumor cells...
FDA Regulatory Changes Signal Shift for Rare Disease and CAR-T Development
The FDA is undergoing significant regulatory evolution with landmark reviews illuminating policies for rare disease therapies, including biomarker-based accelerated approvals for orphan drugs....
Wholomics Advances Multi-Cancer Detection Through Metabolomic Signatures
Wholomics, a biotech startup founded by researchers from Dana Farber and University College London, revealed early data demonstrating its nuclear magnetic resonance-based metabolomic platform's...
Molecular Findings Link Citrate Transporter Mutations to Severe Epilepsy
Researchers at CeMM Research Center for Molecular Medicine have comprehensively characterized the function and structure of the citrate transporter SLC13A5, elucidating how mutations result in a...
Emerging Technologies in Biotech: Single Nanoparticle Analysis Enhances CAR-T Development
NanoFCM's single-molecule NanoAnalyzer technology is advancing in vivo CAR-T therapy development by enabling detailed characterization of lipid nanoparticles (LNPs) used for targeted delivery. The...
Qiagen Expands Clinical Digital PCR Menu through Partnership Program
Qiagen has launched a digital PCR partnership program to accelerate the development of innovative assays for its QiAcuityDx clinical platform. After registering its first partner, Gencurix, Qiagen...
FDA Eases CAR-T Therapy Restrictions to Expand Access
The U.S. Food and Drug Administration (FDA) has significantly relaxed regulatory requirements for CAR-T cell therapies, eliminating the mandated Risk Evaluation and Mitigation Strategies (REMS)...
Alphabet’s Calico Seals $596M Deal for Anti-Aging Candidate
Calico Life Sciences, backed by Alphabet, has entered into a deal valued up to $596 million with Mabwell Bioscience to acquire exclusive rights to investigational IL-11 targeting therapeutics,...