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Novel CAR T-Cell Therapy Employed to Treat Severe Autoimmune Neuropathy
A clinical milestone has been achieved at Ruhr-University Bochum with the first successful application of chimeric antigen receptor (CAR) T-cell therapy to treat chronic inflammatory demyelinating...
Advances in Single-Cell Transcriptomics Reveal PTSD-Linked Brain Cell Dysregulation
New insights into post-traumatic stress disorder (PTSD) reveal alterations in cellular communication within the prefrontal cortex involving inhibitory neurons, microglia, and other glial cells....
Discovery of Lanthanide-Carbon Triple Bond Encapsulated in Fullerene Cage
An international collaboration led by Jiang et al. has reported the synthesis and characterization of a cerium-carbide cluster exhibiting a lanthanide–carbon triple bond stabilized inside a C80...
H5N1 Virus Immune Evasion Unveiled by AI
Scientists at the University of North Carolina at Charlotte have used advanced artificial intelligence models, including AlphaFold 3, to analyze over 1,800 viral proteins of the H5N1 avian...
Advanced Polymeric Membranes for Precision Ion Transport
Researchers from the Dalian Institute of Chemical Physics have developed ultrathin polymeric membranes using an interfacial polymer cross-linking method that creates nanoscale separation layers...
Interstitial Fluid’s Role in Tissue Mechanics Explored
An MIT engineering team has unveiled the critical influence of intercellular fluid—the watery medium occupying spaces between cells—on tissue flexibility and mechanical response under deformation....
Advances in Pediatric Pharmacogenetics for Drug Personalization
The emerging domain of pediatric pharmacogenetics seeks to optimize medication regimens based on genetic variation influencing drug metabolism in children. Unlike adult populations, pediatric...
Breakthrough Canine Mesenchymal Stem Cell Generation from iPSCs
Osaka Metropolitan University researchers report a novel method for producing high-quality canine mesenchymal stem cells derived from induced pluripotent stem cells sourced from various somatic...
Novel Fusion Architecture Employs Semi-Supervised Learning for Parkinson’s Detection via Speech
Researchers have pioneered a fusion architecture combining multiple machine learning models employing semi-supervised speech embeddings to detect Parkinson’s disease through subtle vocal...
Innovative Nanoparticle System Enhances Drug Delivery Stability and Loading
Scientists from Xi’an Jiaotong-Liverpool University and Nanjing University have engineered a protein-polymer coassembly supraparticle combining PLGA polymer and albumin protein, achieving...
FDA Initiates Pilot Program for Accelerated Drug Review Supporting National Priorities
FDA Commissioner Marty Makary announced a pilot Commissioner’s National Priority Voucher (CNPV) program aimed at expediting the review of medicines that address U.S. national interests, including...
Prothena Cuts Workforce by 63% After Phase 3 Amyloidosis Drug Failure
Biotech company Prothena announced a substantial workforce reduction, laying off 63% of its employees following the failure of its phase 3 trial for the monoclonal antibody birtamimab targeting...
Lanthanide–Carbon Triple Bond Discovery in Fullerene
Researchers have achieved a landmark breakthrough in organometallic chemistry by isolating a lanthanide–carbon triple bond encapsulated within a fullerene cage. This study reports the synthesis...
Menin Inhibition Emerges for Acute Leukemia Treatment
In a critical advancement against aggressive acute leukemias, menin inhibitors are gaining traction as novel targeted therapies. AML and ALL, characterized by uncontrolled proliferation due to...
In Vivo CAR T Cell Generation via Targeted Lipid Nanoparticles
A transformative innovation in immunotherapy has been unveiled whereby chimeric antigen receptor (CAR) T cells can be generated directly within patients rather than ex vivo. By utilizing lipid...
Gilead’s Lenacapavir FDA Approval for Twice-Yearly HIV Prevention
Gilead Sciences received FDA approval for its long-acting injectable HIV pre-exposure prophylaxis drug, lenacapavir (Yeztugo), marking a major step forward in preventing HIV infection....
Zealand Pharma’s Dual GLP-1/GLP-2 Agonist Shows Weight Loss Potential
Zealand Pharma has presented updated phase 1b clinical trial data for dapiglutide, a dual glucagon-like peptide-1 and -2 receptor agonist, which induced a mean body weight reduction of 11.6% after...
Breakthrough in Artificial Cells with Model Nuclei via Microfluidics
Researchers at Chuo University, led by Professor Hiroaki Suzuki, have developed a cutting-edge method for mass-producing artificial cells containing model nuclei using microfluidic technology. The...
Breakthrough Stem Cell Method Produces Canine Mesenchymal Stem Cells
Osaka Metropolitan University researchers have pioneered a novel technique to generate high-quality mesenchymal stem cells (MSCs) from canine induced pluripotent stem cells (iPSCs). By...
Novel Non-Contact Terahertz Spectroscopy Measures Buried PN Junctions
A pioneering non-destructive technique has been developed to precisely determine the depth of buried PN junctions in silicon wafers through terahertz (THz) emission spectroscopy. By stimulating...