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HIV – antibody escape mechanisms
Scientists mapped how diverse HIV-1 strains evade broadly neutralizing antibodies, detailing multiple molecular routes to immune escape. The study by Stabell, Lee, Park and colleagues describes...
Gene therapy – GLP-1 one-and-done approach
European regulators have cleared Fractyl Health to begin a clinical study of a GLP-1 gene therapy candidate. The decision adds momentum to efforts to replace chronic GLP-1 injections and pills...
Oncology – OX40 agonist plus Keytruda early midphase signal
Inhibrx said its OX40 agonist paired with Merck’s Keytruda doubled response rates in a midphase clinical trial, encouraging advancement of the combination program. The early data arrive amid...
Oncology – bladder cancer gene therapy durability questions hit the stock
enGene’s Phase II LEGEND update for its nonviral gene therapy detalimogene in high-risk BCG-unresponsive NMIBC showed lower complete response and durability than prior readouts, triggering a sharp...
Regulatory and company strategy – Roche buys PathAI for digital pathology
Roche agreed to acquire PathAI for $750 million upfront to expand AI-powered digital pathology tools for biopharma and pathology labs. The deal targets workflow and analysis capabilities that can...
Funding – Windward Bio lands $165M for respiratory antibody programs
Windward Bio secured $165 million to fund clinical trials of long-acting antibody programs in respiratory diseases and related indications. The financing supports a lead program in asthma and...
Platform / manufacturing innovation – chicken eggs as bioreactors
Neion Bio is advancing an avian bioreactor concept designed to manufacture proteins using genetically engineered chickens that produce target proteins in eggs. The company positions the approach...
Diagnostics and measurement – 10x Genomics launches Atera in situ spatial platform
10x Genomics introduced Atera, an in situ spatial biology platform built to deliver whole-transcriptome spatial analysis with single-cell sensitivity at scale. The platform is designed for both...
Clinical development – cell model accelerates rhinovirus C research
Researchers developed a cell-based infection model for rhinovirus C (RV-C), aiming to overcome longstanding experimental constraints around studying the virus. Published in npj Viruses, the...
Corporate finance / impairment risk – CSL issues revenue warning and $5B write-down
CSL slumped to a nine-year low after warning of lower full-year revenue guidance and announcing a $5 billion impairment charge. The company linked the update to a revised outlook that includes...
AI in protein design and safer lab use
A new report focuses on making protein language models (pLMs) safer and more transparent as they become embedded in protein design workflows. The piece outlines how current pLM...
Roche deal for AI digital pathology
Roche announced it will acquire PathAI for $750 million upfront, aiming to expand AI-powered capabilities in digital pathology workflows. The deal targets PathAI’s technology used by pathology...
Clinical update in oncology gene therapy
enGene’s shares plunged after updated Phase II LEGEND trial data for its nonviral gene therapy candidate, detalimogene (formerly EG-70), in high-risk BCG-unresponsive nonmuscle invasive bladder...
Asset-backed CF funding for Anagram
Blackstone Life Sciences committed $250 million to Anagram Therapeutics, backing the company’s oral enzyme replacement therapy program for patients with exocrine pancreatic insufficiency. The...
Windward Bio raises for respiratory biologics
Windward Bio secured $165 million to advance long-acting antibody programs across asthma and COPD, with additional development planned for respiratory and dermatological indications. The financing...
Obesity drug evidence in older adults
A new post-hoc analysis set for presentation at ECO 2026 will examine the efficacy and safety of orforglipron in adults aged 65 and older, stratified by obesity with and without type 2 diabetes....
Aging biology gene transfer extends lifespan
Researchers at the University of Rochester reported transferring a longevity-related gene from naked mole rats into mice, with the engineered animals living longer and showing improved health...
Bioequivalence pharmacokinetics for pramipexole ER
Investigators evaluated bioequivalence of pramipexole dihydrochloride extended-release tablets in Chinese healthy volunteers under fasting versus fed conditions. The pharmacokinetic comparison...
Manufacturing logistics and CGT operations
A new analysis spotlights operational bottlenecks in the logistics of next-generation cell and gene therapies, where delivery windows and product sensitivity can be measured in minutes. The report...
National-level research governance risk
A large group of National Academy of Sciences experts denounced the White House’s dismissal of the National Science Board, warning it undermines the country’s ability to engage in basic and...