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CD40 Agonist Antibody Yields Tumor Shrinkage in Metastatic Cancer Trial
A first-in-human Phase I trial of an Fc-optimized CD40 agonistic antibody, 2141.V11, delivered intratumorally, has demonstrated preliminary clinical efficacy in metastatic cancer patients. Among...
Major Biotech Deal Targets Undruggable KRAS G12D Mutation
Bayer and Kumquat Biosciences have entered an exclusive $1.3 billion collaboration to develop and commercialize inhibitors targeting the KRAS G12D mutation, a driver in multiple hard-to-treat...
NIH and US Agencies Scale Back mRNA Vaccine Funding Amid Public Trust Concerns
The US government is withdrawing funding and partnerships supporting mRNA vaccine research for respiratory diseases, citing public trust issues. Despite mRNA vaccine technology’s success in...
Artificial Intelligence Accelerates RNA Therapeutics via Lipid Nanoparticle Design
Researchers at MIT have applied artificial intelligence to streamline the design of lipid nanoparticle (LNP) carriers for RNA vaccines and therapeutics. This work aims to overcome challenges in...
Schrödinger Halts AML Drug Development After Patient Deaths in Trial
Schrödinger has discontinued development of SGR-2921, a CDC7 inhibitor for acute myeloid leukemia (AML), after two patients died in a Phase I dose-escalation study, with the drug considered a...
Syncell and Thermo Fisher Partner to Expand Spatial Proteomics Access
Taiwanese spatial proteomics company Syncell has entered a co-marketing agreement with Thermo Fisher Scientific to integrate Syncell's Microscoop spatial protein purification system with Thermo...
Natural Killer Cell Function Modulated by Serine Metabolism
Recent findings illuminate how serine metabolism intricately regulates natural killer (NK) immune cell functions. Rapid metabolic reprogramming enables NK cells to meet their energy and...
AI-Driven Antibiotics Target Drug-Resistant Bacteria
Researchers at MIT have harnessed generative artificial intelligence to design novel antibiotic molecules effective against drug-resistant Neisseria gonorrhoeae and multi-drug-resistant...
FDA and Biotech Industry Regulatory Developments
The US FDA is undergoing significant transformations amid increasing political and operational pressures. Recent efforts include the launch of the FDA PreCheck program to expedite domestic...
Advancements in Immunotherapies for Cancer
Significant clinical and preclinical advances in cancer immunotherapy have emerged. UCLA-led studies demonstrate pembrolizumab's ability to induce sustained regressions in advanced desmoplastic...
Sustainable Agriculture and Crop Yield Innovations in China
Multiple studies highlight China's advances in sustainable crop production. Researchers elucidate strategies to boost corn and rice yields while improving resource efficiency and mitigating...
Breakthroughs in Neurodegenerative and Psychiatric Disorders Research
Pivotal studies elucidate mechanisms and therapeutic avenues in neurodegeneration and psychiatry. Mount Sinai researchers link prenatal acetaminophen exposure to heightened autism and ADHD risks....
Gene Regulation and Evolutionary Biology Insights
Researchers reveal new insights into gene regulation and evolutionary mechanisms with broad implications. Studies of de novo genes in Drosophila identify key transcription factors accounting for...
Innovations in Battery and Energy Storage Technologies
Recent breakthroughs in battery science promise safer, more efficient energy storage solutions. Novel quasi-solid electrolytes for lithium-ion and magnesium batteries enhance stability and...
Artificial Intelligence Applications in Biotech and Healthcare
Artificial intelligence continues to revolutionize diverse aspects of biotechnology and medicine. Novel AI platforms accelerate drug discovery, enabling large-scale data generation and molecular...
Agricultural and Environmental Biotechnology Innovations
Innovative research tackles critical challenges in agriculture and environmental sustainability. Advances in breeding climate-resilient crops and digital twin frameworks enhance modular building...
AI Accelerates Antibiotic Development Against Drug-Resistant Bacteria
Researchers at MIT and collaborators have harnessed generative AI to design novel antibiotics targeting drug-resistant pathogens like Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus...
Novel CD40 Agonist Shows Systemic Efficacy in Metastatic Cancer Trial
A Phase I clinical trial evaluated the Fc-optimized CD40 agonistic antibody 2141.V11 administered intratumorally in metastatic cancer patients. The study reported tumor shrinkage in half of the 12...
Schrödinger Discontinues CDC7 Inhibitor After Treatment-Related Deaths
Schrödinger halted development of SGR-2921, a cell division cycle 7 (CDC7) inhibitor for acute myeloid leukemia and high-risk myelodysplastic syndromes, following two patient deaths linked to the...
Superluminal and Lilly Ink $1.3 Billion Pact on GPCR Cardiometabolic Drugs
Superluminal Medicines secured up to $1.3 billion in a collaboration deal with Eli Lilly to develop small-molecule therapies targeting undisclosed G protein-coupled receptors (GPCRs) implicated in...