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AI and Machine Learning Drive Advances in Biotech Research and Drug Discovery
Several breakthroughs demonstrate AI’s growing role in biotechnology: Imperial College London and GSK developed a hybrid machine learning model improving monoclonal antibody design space...
FDA Approves Insmed’s Brensocatib as First Treatment for Non-Cystic Fibrosis Bronchiectasis
The FDA granted approval to Brinsuprí (brensocatib), an oral DPP1 inhibitor developed by Insmed for treating non-cystic fibrosis bronchiectasis (NCFB) in patients aged 12 and older. This marks the...
Cancer Vaccine Cylembio Narrowly Misses Primary Endpoint but Plans FDA Filing
IO Biotech’s off-the-shelf cancer vaccine Cylembio in combination with Merck’s Keytruda demonstrated encouraging but narrowly missed statistically significant improvement in progression-free...
Advances in Antibody and Cell Therapy Manufacturing Partnerships
Sartorius Stedim Biotech entered a partnership with Nanotein Technologies involving a $3 million minority investment to commercialize and co-develop products that enhance immune cell...
Regulatory Developments and Leadership Changes at the FDA
Vinay Prasad was reinstated as director of the FDA’s Center for Biologics Evaluation and Research (CBER) two weeks after his removal amid political controversy. His return elicited a muted market...
Neuroscience Breakthroughs in Brain Aging, Neurodegeneration, and Biomarkers
Recent studies unveiled significant insights into brain aging and neurodegenerative diseases: Researchers showed nuanced layer-specific cortical aging patterns in mice and humans. A new molecular...
Boston Life Sciences Market Faces Real Estate Overcapacity and Funding Slowdown
Greater Boston’s life sciences real estate market confronts a record 17 million square feet of vacant lab space amid cooling venture capital funding and macroeconomic headwinds. New speculative...
Novartis Cleaves Autoimmune Disease with Dual Phase 3 Wins
Novartis announced significant progress in treating Sjögren's syndrome with its B-cell-targeting antibody ianalumab. The drug met primary endpoints in two late-stage Phase 3 trials, marking the...
Cancer Vaccines: IO Biotech’s Narrow Miss in Melanoma Trial
IO Biotech’s off-the-shelf therapeutic cancer vaccine Cylembio narrowly missed its primary endpoint in a pivotal Phase 3 melanoma study, falling just short of statistical significance despite...
Expedition Therapeutics In-Licenses Fosun Lung Disease Drug
Expedition Therapeutics secured a licensing deal worth up to $645 million to develop and commercialize Fosun Pharma’s experimental DPP-1 inhibitor outside China, marking its first public drug...
Boehringer Ingelheim Scores FDA Nod for Lung Cancer Drug Hernexeos
Boehringer Ingelheim’s oral HER2-targeted therapy, Hernexeos (zongertinib), gained accelerated approval from the FDA for non-small cell lung cancer patients with specific HER2 activating...
AI Breakthroughs Advance Disease Diagnostics and Patient Care
Recent innovations harness artificial intelligence to transform medical diagnostics and emergency care. Researchers developed AI models that enable early detection of voice box cancer through...
Gene Editing Advances: Precision and Safety Enhancements
Groundbreaking research has enhanced genome editing precision through novel microhomology-based DNA template design guided by deep learning algorithms, improving targeted DNA integrations in...
Mitochondrial Activation Reverses Neurodegenerative Deficits in Models
A team from Inserm and Université de Bordeaux developed mitoDREADD-Gs, a mitochondria-targeted designer receptor that, when activated, enhances mitochondrial energy functions and reverses...
Breakthroughs in Cancer Therapy: Targeted Vaccines and Metabolic Drugs
Innovative cancer treatments show promise across multiple fronts. A peptide-based vaccine inducing immune responses against lymph node-resident cancer cells demonstrates encouraging results in...
Biotech Market Volatility and Leadership Shifts at FDA
Vinay Prasad has been reinstated as director of the FDA’s Center for Biologics Evaluation and Research (CBER) just two weeks after his ouster following political controversy. The return was...
Pfizer's Padcev Extends Survival in Bladder Cancer Combo
Pfizer announced that its antibody-drug conjugate Padcev, when combined with the immunotherapy Keytruda, significantly extended survival in patients with invasive bladder cancer who were...
Novartis Scores Dual Phase 3 Wins in Sjögren’s Syndrome
Novartis secured two successful Phase 3 trial results for ianalumab, an antibody targeting BAFF-R, in patients with Sjögren’s syndrome, a challenging autoimmune disorder. Both NEPTUNUS 1 and 2...
IO Biotech’s Cancer Vaccine Misses Primary Endpoint Narrowly
IO Biotech’s experimental cancer vaccine Cylembio, combined with Merck’s Keytruda, narrowly missed its primary endpoint of progression-free survival in a Phase 3 melanoma trial. Despite a hazard...
AI Enables Early Detection of Voice Box Cancer
Researchers have developed an AI-driven method analyzing acoustic features from voice recordings to identify benign and malignant vocal cord lesions noninvasively. Derived from the Bridge2AI-Voice...