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PanMAN: compressed pangenomics scales whole‑genome analysis
A UC San Diego team published PanMAN (Pangenome Mutation‑Annotated Network), a new data structure and compression method that achieves up to ~1,391× file‑size reduction versus existing...
Trenchant’s AutoCell prototype claims 2.5‑day CGT run and 7× yield vs today’s standards
Trenchant BioSystems released internal and third‑party data for its AutoCell cell‑and‑gene therapy (CGT) manufacturing prototype, saying the platform can cut vein‑to‑vein timelines from ~6 weeks...
Tessera cleared to start TSRA‑196 trial: in vivo gene editing for AAT deficiency moves to clinic
Tessera Therapeutics received FDA clearance of an IND and Australian HREC approval to initiate a Phase I/II study of TSRA‑196, its in‑vivo gene‑editing candidate for α‑1 antitrypsin deficiency...
Mirador raises $250M: positions to expand immunology pipeline and eye an IPO
Mirador Therapeutics closed a $250 million Series B to advance its precision immunology pipeline and signaled plans to consider an IPO later this year. The financing, led by major life‑science...
AbbVie pens $5.6B pact with RemeGen – joins PD‑1xVEGF race
AbbVie struck an exclusive licensing deal with RemeGen to acquire rights to a PD‑1/VEGF bispecific antibody program, paying $650 million up front and agreeing to development and commercial...
Nvidia–Lilly $1B co‑lab: AI to speed drug discovery
Nvidia and Eli Lilly announced a joint, five‑year investment of up to $1 billion to build an AI drug‑discovery laboratory in San Francisco, committing infrastructure, compute and shared talent to...
Basecamp’s EDEN AI: programmable gene insertion at scale
Basecamp Research reported EDEN, an evolutionary AI family, can design enzymes that enable programmable insertion of large DNA sequences at specified genomic sites, demonstrating insertion at over...
Tahoe, Arc and Biohub commit multimillion dataset: 120M+ single‑cell perturbations
Tahoe Therapeutics, the Arc Institute and Biohub announced a joint commitment to generate a publicly available, perturbation‑heavy single‑cell dataset aimed at training and validating virtual cell...
Oxford Nanopore gets CE/UKCA mark for GridIon Dx – clinical push ramps
Oxford Nanopore announced CE‑IVDR and UKCA marking for its GridIon Dx sequencer, making it the company's first regulated IVD device in Europe and the UK and enabling clinical deployment in...
Trenchant claims AutoCell prototype slashes CGT timelines: 2.5‑day vein‑to‑vein
Trenchant Biosystems released internal and third‑party validation data for its AutoCell automated cell‑and‑gene‑therapy (CGT) manufacturing prototype, asserting it can reduce vein‑to‑vein...
10x Genomics pivots to clinic: collaborations and CLIA lab planned
10x Genomics announced three clinically oriented collaborations—Dana‑Farber, the Cancer Research Institute and Brigham and Women’s Hospital—aimed at generating large single‑cell and spatial...
PacBio teams with n‑Lorem and EspeRare on individualized ASOs; revenue rises
Pacific Biosciences said it will collaborate with the n‑Lorem Foundation and EspeRare to study individualized antisense oligonucleotide (ASO) therapies, deploying PacBio HiFi long‑read...
FDA exercises flexibility in CGT chemistry, manufacturing and controls
The FDA’s Center for Biologics Evaluation and Research announced steps to modernize and provide more flexible chemical, manufacturing and control (CMC) expectations for cell and gene therapies,...
CRISPR excises NOTCH2NLC expansions: new approach targets NIID
Researchers reported a CRISPR/Cas9‑based strategy that precisely targets and excises pathogenic GGC repeat expansions in the NOTCH2NLC gene implicated in neuronal intranuclear inclusion disease...
Lilly and Nvidia: $1B lab to accelerate AI drug discovery
Eli Lilly and Nvidia announced a joint five-year investment — up to $1 billion — to establish a San Francisco lab focused on AI-driven drug discovery. Lilly will provide biological and clinical...
Basecamp’s EDEN models: AI designs programmable gene insertions
Basecamp Research, working with Nvidia and NVentures investment, disclosed EDEN — an ‘‘evolutionary AI’’ family of models that the company says can design sequences for programmable insertion of...
WHO flags equity gaps in genomic clinical research: geographic and demographic imbalances
The World Health Organization published a report highlighting imbalances in clinical genomics research: over 80% of registered genomic studies occur in high-income countries while under 5% take...
FDA eases CMC rules for cell and gene therapies – more regulatory flexibility
The US Food and Drug Administration’s Center for Biologics Evaluation and Research (CBER) issued guidance detailing steps to offer greater regulatory flexibility on chemistry, manufacturing and...
Tahoe, Arc and Biohub join to build massive perturbation-rich virtual‑cell dataset
Tahoe Therapeutics, the Chan‑Zuckerberg Biohub and the Arc Institute committed multi‑million dollar resources to create an open-source perturbation dataset designed to train next-generation...
Diagnostics surge: Tempus and Guardant post big preliminary revenue gains
Two diagnostics and data firms reported strong preliminary fourth-quarter results driven by testing volume growth. Tempus disclosed preliminary Q4 revenue of about $367 million, an 83%...