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Livanova Seeks CMS Coverage Change to Expand Vagus Nerve Stimulation for Depression
Livanova plc is petitioning CMS to remove the coverage with evidence development mandate for its vagus nerve stimulation device for treatment-resistant depression, aiming to streamline patient...
Merck Wins FDA Nod for Pediatric RSV Antibody as CDC Vaccine Panel Faces Uncertainty
Merck’s monoclonal antibody Enflonsia (clesrovimab) received FDA approval to prevent RSV lower respiratory tract disease in infants under 12 months, entering a competitive pediatric market...
NIH Staff Protest Scientist Cuts and Funding Politicization: Bethesda Declaration Gains Momentum
Over 300 current and former NIH employees have signed the Bethesda Declaration, a formal letter addressed to NIH Director Jay Bhattacharya, criticizing recent grant cancellations, funding freezes,...
Alzheimer’s Disease Proteomic Atlas: Alamar Biosciences Partners with Global Entities for Biomarker Discovery
Alamar Biosciences, in partnership with the Alzheimer’s Disease Data Initiative and Gates Ventures, initiated a large-scale proteomic profiling project using ultra-sensitive NULISA™ technology...
Epigenetics and Early Cancer Detection: Expanded Window via DNA Methylation Sequencing
Recently published research highlights the transformative potential of DNA methylation and hydroxymethylation sequencing technologies in enabling early cancer detection. By profiling methylation...
Breakthrough in Metabolism Research: UC San Diego Maps Hundreds of New N-Acyl Lipids
A comprehensive study from UC San Diego catalogs 851 distinct N-acyl lipids across human tissues and biofluids, including 777 previously unidentified compounds. The findings illuminate crucial...
Advances in Cancer Immunotherapy: Nagoya University’s CAR-T Targets Solid Tumors via Eva1 Antigen
Researchers led by Nagoya University unveiled a next-generation CAR-T cell therapy designed to target solid tumors by recognizing the antigen Eva1 (MPZL2), expressed prevalently in lung,...
Innovations in AI and Computational Biology: Northwestern’s AI Tool Maps Gene Combinations in Complex Diseases
Northwestern University researchers have developed an advanced generative AI computational model, leveraging a transcriptome-wide conditional variational autoencoder (TWAVE), to identify key gene...
Recursion Pharmaceuticals Cuts Workforce by 20% Amid Pipeline Pruning and Funding Challenges
AI-driven drug developer Recursion Pharmaceuticals announced layoffs constituting approximately 20% of its workforce, equating to 160 positions, reflecting its pipeline streamlining and...
Cancer Drug Development: Antares Launches $177M Post-Scorpion Spinout Backed by Lilly
Antares Therapeutics, formed as a spinout from Scorpion Therapeutics after Lilly’s acquisition, has raised $177 million in a Series A round to continue advancing preclinical oncology drug...
FDA Clears Merck’s Pediatric RSV Antibody Amid U.S. Vaccine Advisory Turmoil
The FDA approved Merck's monoclonal antibody, Enflonsia (clesrovimab), for prevention of lower respiratory tract disease caused by respiratory syncytial virus (RSV) in infants under 12 months....
Gene Therapy Funding Surge: SpliceBio’s $135M Series B and Dual AAV Gene Therapy Clinical Milestone
SpliceBio has secured $135 million in a Series B funding round co-led by EQT Life Sciences and Sanofi Ventures, with participation from Roche Ventures and existing investors. The capital will...
FDA Places Clinical Hold on Gilead’s Long-Acting HIV Combo Trials
FDA halted multiple Gilead phase 1 and phase 2/3 trials for investigational HIV combo drugs following safety signals of immune cell count reductions, delaying critical research and raising...
Argenx Expands Autoimmune Drug Vyvgart Trials With Promising Results
Argenx announced promising data for its autoimmune drug Vyvgart in two new indications, expanding its therapeutic potential beyond current approvals. The positive results bolster Argenx's pipeline...
RFK Jr. ousts entire CDC vaccine advisory committee
HHS Secretary Robert F. Kennedy Jr. has removed all 17 members of the CDC’s Advisory Committee on Immunization Practices (ACIP), pledging to replace them with his own appointees. This...
FDA Places Clinical Hold on Gilead’s Long-Acting HIV Combo Trials
The FDA has imposed a clinical hold on five Gilead studies testing combinations of investigational long-acting HIV drugs GS-1720 and GS-4182 due to a safety signal involving lowered CD4 and...
Metsera Shows Promising Phase I Data for Long-Acting Amylin Analogue Against Obesity
Metsera reported encouraging Phase I results for its amylin analogue MET-233i, exhibiting dose-dependent weight loss and a pharmacokinetic profile supporting once-monthly dosing. This therapy may...
Merck’s Oral PCSK9 Inhibitor Shows Significant Cholesterol Reduction in Phase III
Merck’s once-monthly oral PCSK9 inhibitor enlicitide decanoate demonstrated robust and clinically meaningful reductions in LDL cholesterol levels across two phase III Coralreef studies in...
NIH Scientists Protest Research Politicization and Funding Cuts
Over 300 current and former NIH staff signed the Bethesda Declaration protesting politicization and drastic budget cuts under the Trump administration and NIH leadership. They highlight terminated...
Alamar Biosciences Partners Globally for Alzheimer’s Proteomic Biomarker Study
Alamar Biosciences, alongside the Alzheimer’s Disease Data Initiative and Gates Ventures, launched a large-scale international collaboration to generate a comprehensive plasma proteomic dataset...