Latest Biotech News

Roginolisib, a conformation-selective PI3Kδ inhibitor, delivered a first-in-human safety profile in an early cancer trial and generated median overall survival signals up to 20.8 months in...

A phase II trial in HER2-positive early breast cancer found that a pyrotinib-based neoadjuvant regimen delivered pathological response rates comparable to the standard trastuzumab–pertuzumab...

An AI-designed gallium-68 PET tracer targeting PARP-1 completed a first-in-human evaluation in breast and ovarian cancer patients. The project used an AI-assisted design pipeline to generate...

Johns Hopkins Medicine researchers provided clinical validation supporting the first FDA-cleared rapid urine test to aid diagnosis of invasive aspergillosis. The approach aims to reduce...

A new Infection Control and Hospital Epidemiology analysis using six months of intensive surveillance and computational modelling reports that asymptomatic patients account for the overwhelming...

Researchers at Nanjing Medical University reported an AI-generated T-cell engager for gastric cancer designed to recruit immune cells, but durable antitumor responses required added dendritic-cell...

European Parkinson’s specialists issued consensus recommendations for the newly approved dual-release levodopa formulation IPX203, aimed at patients experiencing motor fluctuations. The guidance...

A single-cell multi-omics atlas of neuroendocrine carcinoma of the cervix identified DLL3 as a driver of immune evasion and validated DLL3-targeted therapy in patient-derived organoid models. The...

A patient-level synthesis of 40 published cases mapped nivolumab-induced hypophysitis, reporting predominant damage to the pituitary’s cortisol-regulating axis and strong responsiveness to...

A Science study reported that gut bacteria—particularly flagellin-producing Lachnospiraceae—along with diet influenced whether individuals developed fever after mRNA vaccination, without changing...

A multinational analysis reported that reductions in infant bronchiolitis after nirsevimab introduction varied widely across Europe and closely tracked regional immunization coverage, highlighting...

First-in-human data for roginolisib, a conformation-selective PI3Kδ inhibitor, showed acceptable tolerability in advanced cancers and survival signals in metastatic uveal melanoma, reaching median...

An early proof-of-concept study using CT radiomics to predict response to radiotherapy in elderly esophageal cancer patients showed unstable performance when fully nested validation was used. The...

A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identified DLL3 as a driver linked to immune evasion and validated DLL3-targeted therapy in patient-derived organoid...

A blood-based lipid biomarker approach identified sphingomyelin (30:1; O2) as a serum signal that outperformed conventional tumor markers in distinguishing intrahepatic cholangiocarcinoma from...

A two-year, 14-hospital Italian investigation of multi-carbapenemase-producing Klebsiella pneumoniae found extensive resistance and genomic diversity across isolates. Despite that variability,...

A pharmacovigilance analysis of nearly five million adverse-event reports found that liver injury after CAR T-cell therapy is predominantly early and linked to cytokine release syndrome, while...

Johns Hopkins Medicine researchers supported clinical validation for the first FDA-cleared rapid urine test to aid diagnosis of invasive aspergillosis. The approach aims to shorten diagnostic...

Ritonavir, an approved HIV protease inhibitor, was reported to bind cytomegalovirus immediate-early protein IE1 and drive ubiquitin-proteasome-mediated degradation, blocking viral replication in...

A nationwide cohort study reported that returning mailed multitarget stool DNA screening kits was associated with a 55% lower rate of subsequent colorectal cancer compared with not returning the...