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Vaxart’s Covid Vaccine Trial Faces Second Stop-Work Order Amid Uncertainties
Vaxart received another stop work order for its federally funded oral Covid-19 vaccine Phase 2b trial managed by Advanced Technology International, halting most trial activities despite ongoing...
AI Advances Early Detection of Voice Box Cancer via Acoustic Analysis
Researchers have developed AI models capable of distinguishing laryngeal cancer from benign vocal cord lesions through detailed acoustic feature analysis of voice recordings. Utilizing datasets...
Prime Editing Extends Genome Editing Capabilities Beyond Point Mutations
David Liu’s team at Harvard has advanced genome editing with twin prime editing, expanding the editing length capacity to 100 base pairs and improving safety over traditional CRISPR approaches....
Mitochondria-Targeted Receptor Restores Cognition in Neurodegenerative Models
A novel designer receptor, mitoDREADD-Gs, engineered to activate stimulatory G-protein signaling within brain mitochondria, has been shown to reverse cognitive impairments in mouse models of...
Breastmilk IgA Antibodies Modulate Infant Gut Microbiota and Allergy Risks
Researchers from the University of British Columbia revealed that IgA antibodies in breastmilk specifically inhibit the gut bacterium Erysipelatoclostridium ramosum, which is implicated in...
Biotech Funding Slows: Standard BioTools Revenues Fall Amid Transformation
Standard BioTools reported a 3% year-over-year revenue decline in Q2 2025, with notable decreases in instrument and service sales offset somewhat by consumables growth. The company’s net loss...
Sartorius and Nanotein Partner to Enhance Immune Cell Therapy Production
Sartorius Stedim Biotech announced a partnership and minority investment in Nanotein Technologies to commercialize NanoSpark® platform products aimed at improving T cell and natural killer cell...
AI Breakthroughs in Cancer and Voice Box Diagnostics
Recent advances showcase the growing role of artificial intelligence in cancer detection and treatment research. Tahoe Therapeutics raised $30 million aiming to build AI models of living human...
Next-Generation Genome Editing: Prime Editing Expands CRISPR Applications
Prime editing emerges as a versatile and safer alternative to traditional CRISPR technology, enabling precise genome modifications without double-stranded DNA breaks. Biochemist David Liu's...
Mitochondrial Therapeutics Reverse Neurodegeneration in Animal Models
Targeting mitochondrial dysfunction presents a promising strategy for neurodegenerative diseases such as Alzheimer's and frontotemporal dementia. Researchers developed mitoDREADD-Gs, a...
Novartis Scores in Sjögren’s Syndrome with Dual-Mechanism Antibody
Novartis reported successful phase 3 trial results for ianalumab, an antibody targeting BAFF-R, in patients with Sjögren’s syndrome. The drug demonstrated statistically significant reductions in...
IO Biotech’s Cancer Vaccine Misses Endpoint but Eyes FDA Filing
IO Biotech's off-the-shelf therapeutic cancer vaccine Cylembio narrowly failed to demonstrate statistical significance for progression-free survival when combined with Keytruda in unresectable or...
Boehringer Ingelheim’s Hernexeos Gains Accelerated FDA Nod for Lung Cancer
Boehringer Ingelheim secured accelerated FDA approval for Hernexeos (zongertinib), the first oral HER2-targeted therapy for adults with advanced non-small cell lung cancer harboring HER2 tyrosine...
Microbiome Influences Immune Development and Chronic Pain Conditions
Emerging research highlights the profound role of the microbiome in shaping human health. Newborn immune system maturation is influenced by breastmilk antibodies, particularly IgA, which modulate...
Biotech Industry Navigates Funding and Market Pressures Amidst Innovation
Biotech firms face a complex landscape marked by capital constraints and evolving regulatory environments. Standard BioTools reported a 3% revenue decline in Q2 2025 despite consumables growth,...
AI and Machine Learning Enhance Medical Diagnostics and Emergency Care
Artificial intelligence continues to accelerate innovations in healthcare delivery and diagnostics. Mount Sinai researchers developed AI models that predict hospital emergency admissions earlier...
Insights into Brain Function and Movement Disorders from Animal Models
Recent neuroscience studies are uncovering mechanisms underlying motor control and brain aging. Harvard researchers demonstrated that basal ganglia in rats use distinct neural codes for innate...
Boehringer Ingelheim Lung Cancer Drug FDA Nod: Hernexeos Clears Accelerated Approval
Boehringer Ingelheim's oral HER2-targeted drug, Hernexeos (zongertinib), received accelerated FDA approval for advanced non-small cell lung cancer (NSCLC) patients harboring HER2 tyrosine kinase...
IO Biotech Cancer Vaccine Phase 3 Trial Narrowly Misses Endpoint But FDA Filing Planned
IO Biotech’s therapeutic cancer vaccine Cylembio combined with Merck’s Keytruda failed to meet the primary endpoint in a pivotal Phase 3 trial for unresectable or metastatic melanoma, narrowly...
Novartis Secures Dual Phase 3 Wins with Ianalumab in Sjögren’s Syndrome
Novartis announced positive results from two Phase 3 studies evaluating ianalumab, a B-cell-depleting antibody targeting BAFF-R, in Sjögren’s syndrome. Both trials met their primary endpoints,...