Get the Daily Brief
Latest Biotech News
Advancements in Targeted Cancer Therapeutics with ADCs and Immunotherapies
Lonza’s Synaffix has partnered with Qurient Therapeutics to develop dual-payload antibody-drug conjugates (ADCs) combining exatecan-based cytotoxics with a CDK7 inhibitor for solid tumors, aiming...
Innovative Biotechnologies Targeting Metabolism and Immune Regulation in Cancer and Neurodegeneration
Pivotal research continues to link metabolic and immune pathways in malignant and neurodegenerative diseases. UCLA scientists identified IGF2BP3 as a key regulator that reprograms metabolism and...
Trump's Pharmaceutical Tariffs Face Carve-Outs and Regulatory Uncertainty
President Donald Trump announced a 100% tariff on branded pharmaceutical imports starting October 1, aiming to incentivize domestic manufacturing. However, key exemptions for generic drugs,...
UniQure Gene Therapy Shows Promise in Slowing Huntington’s Disease Progression
UniQure Therapeutics reported positive topline results from its pivotal Phase I/II trial of AMT-130 for Huntington’s disease, meeting its primary endpoint with a statistically significant 75%...
Breakthroughs in Programmable Genome Rearrangements by Bridge Recombinases
Researchers at the Arc Institute have developed novel bridge recombinases that enable unprecedented genome engineering by performing massive, programmable DNA rearrangements spanning hundreds of...
Innovations in Immunotherapy and CAR T Cell Enhancements
New research highlights genetic modifications that enhance CAR T cell persistence and efficacy in multiple myeloma models. Using CRISPR screening, scientists identified gene knockouts such as...
AI and Machine Learning Transformations in Biotech and Diagnostics
Artificial intelligence systems are advancing capabilities from drug prescription to diagnostic accuracy. An autonomous AI helped optimize treatment to prevent graft-versus-host disease in stem...
NIH Investment Accelerates Shift from Animal Testing to Organoid Models
Building on the FDA's roadmap to reduce animal testing in drug development, the National Institutes of Health has awarded $87 million over three years to establish the Standardized Organoid...
Crinetics Secures FDA Nod for Acromegaly Drug Amid Competitive Therapeutic Landscape
Crinetics Pharmaceuticals received FDA approval for Palsonify, a once-daily oral treatment for acromegaly, offering a new option for patients ineligible for or unresponsive to surgery. The therapy...
Novel mRNA Vaccine Shows Promise Against Age-Related Macular Degeneration
Researchers at the Institute of Science Tokyo have developed a pioneering mRNA vaccine targeting pathological retinal neovascularization, a key factor in age-related macular degeneration (AMD)....
Lonza and Qurient Partner on Dual-Payload Antibody-Drug Conjugates for Solid Tumors
Lonza's Synaffix platform has entered a licensing collaboration with Qurient Therapeutics to develop a novel dual-payload antibody-drug conjugate (ADC) integrating Synaffix’s exatecan technology...
Groundbreaking Soil and Plant Innovations Enhance Agriculture Sustainability and Food Security
Multiple research breakthroughs offer promising solutions for sustainable agriculture under climate challenges. A fully biodegradable hydrogel supports soilless farming in drought conditions,...
UniQure’s AMT-130 Gene Therapy Slows Huntington’s Progression
UniQure announced positive topline data from its pivotal phase I/II trial evaluating AMT-130 for Huntington’s disease (HD), demonstrating statistical significance in slowing disease progression by...
Hansa Biopharma’s Imlifidase Enables Kidney Transplants in Highly Sensitized Patients
Hansa Biopharma reported positive outcomes from a pivotal U.S. phase III trial of imlifidase, an enzyme that rapidly cleaves antibodies to facilitate kidney transplantation in highly sensitized...
Eli Lilly’s FDA Nod for Oral SERD Inluriyo in Advanced Breast Cancer
The U.S. Food and Drug Administration approved Eli Lilly’s oral selective estrogen receptor degrader (SERD), Inluriyo (formerly imlunestrant), for adults with metastatic, estrogen...
CRISPR-Enhanced CAR T Advances in Multiple Myeloma
Researchers from Mass General Brigham and the Broad Institute employed in vivo CRISPR screening to identify gene knockouts that significantly improve CAR T cell function and persistence against...
Programming Protein Interaction Kinetics to Control Therapeutics
A University of Washington-led team, including Nobel Laureate David Baker, developed a generalizable molecular on/off protein switch that modulates binder dissociation rates by up to 6,000-fold,...
Longevity Inheritance via Lysosome-Epigenome Pathway in C. Elegans
Scientists at Howard Hughes Medical Institute uncovered a mechanism explaining how longevity traits are inherited across generations in C. elegans. Lysosomal metabolic changes in parent worms...
Arc Institute’s Bridge Recombinases Enable Megabase-Scale DNA Editing
Researchers at the Arc Institute and University of California, Berkeley have engineered RNA-guided bridge recombinases to perform massive, programmable human genome rearrangements spanning...
UniQure’s AMT-130 Gene Therapy Data Send Shares Soaring
Following the announcement of AMT-130’s robust slowing of Huntington’s disease progression at 36 months, UniQure’s stock surged over 200%, reflecting strong market confidence. The trial met both...