Get the Daily Brief

All action, no filler. BioBriefs delivers the industry’s 10 must-know updates, every morning.

Latest Biotech News

CMS launches Medicare GLP‑1 model: voluntary pilot to widen access

December 27, 2025

CMS launched a voluntary payment model intended to expand Medicare coverage of GLP‑1 weight‑loss drugs for eligible beneficiaries. The administration designed the pilot to test payment approaches...

FDA greenlights therapy for fatal transplant complication: first approved option

December 27, 2025

The FDA approved Yartemlea, Omeros’s complement‑system drug, for a severe and potentially fatal complication of hematopoietic stem cell transplants, marking the first regulator‑confirmed therapy...

J&J axes eczema drug — $1.25B acquisition bet fails after Phase 2 miss

December 27, 2025

Johnson & Johnson terminated development of its experimental eczema candidate JNJ‑5939 (NM26) after a Phase 2 trial did not meet efficacy thresholds, ending hopes tied to the $1.25 billion...

Engineered AAVs sense tumors: new vectors aim for precision delivery

December 27, 2025

Researchers published a framework for engineering adeno‑associated virus (AAV) vectors that dynamically respond to features of the tumor microenvironment to enhance tumor targeting and...

Nanovaccines enter HCC immunotherapy pipeline: targeted antigen delivery advances

December 27, 2025

Researchers reported progress on nanovaccine platforms tailored to hepatocellular carcinoma (HCC), demonstrating nanoparticle‑mediated antigen presentation and immune activation in preclinical...

SpatialBench benchmark: testing agents on real spatial biology workflows

December 27, 2025

SpatialBench, a new benchmark suite, evaluates computational agents on 146 verifiable spatial biology problems drawn from real analysis workflows across five platforms (Vizgen MERFISH, 10x Visium,...

CAR‑T neurotoxicity insights sharpen: new data on mechanisms and management

December 27, 2025

Recent advances summarize mechanisms behind CAR‑T cell therapy neurotoxicity, consolidating clinical signals, imaging correlates, and biomarker profiles to refine risk stratification and...

New strategies to overcome lung cancer drug resistance: emerging combos and targets

December 27, 2025

Researchers reported therapeutic approaches aimed at reversing multidrug resistance (MDR) in lung cancer, including novel small molecules, combination regimens, and delivery systems that restore...

Dual‑agent PLGA delivery: cisplatin plus silibinin enhances cervical cancer efficacy

December 27, 2025

A research team demonstrated that encapsulating cisplatin with silibinin inside biodegradable PLGA polymeric nanoparticles improves antitumor efficacy in cervical cancer models compared with free...

Targeted protein degradation: mapped impacts on health, ecology and drug design

December 27, 2025

A comprehensive review examined the biomedical promise and broader effects of targeted protein degradation (TPD), surveying therapeutic potential, off‑target risks, and ecological considerations....

CMS rolls out voluntary Medicare payment model for GLP‑1s

December 27, 2025

CMS launched a voluntary payment model designed to expand Medicare coverage for GLP‑1 weight‑loss drugs. The agency invited plans and providers to participate in a pilot that alters payment and...

FDA greenlights Yartemlea — first therapy for post‑transplant complement injury

December 27, 2025

The FDA approved Omeros’s complement inhibitor Yartemlea to treat a severe, often fatal complication of hematopoietic stem cell transplants. This marks the first approved therapy for the condition...

J&J shutters eczema program from $1.25B acquisition — efficacy shortfall

December 27, 2025

Johnson & Johnson said an experimental eczema medicine acquired for $1.25 billion failed to meet the company’s efficacy standards and the program will be discontinued. The decision closes a...

Biohaven’s ion‑channel drug flops in Phase 2 — depression setback

December 27, 2025

Biohaven reported that its potassium‑channel targeted candidate failed a Phase 2 trial in major depressive disorder, marking a second mid‑stage setback for the program. The company said the drug...

Tumor‑sensing AAVs: Vectors engineered to switch on in tumors

December 27, 2025

Researchers presented an intelligent AAV design framework that programs adeno‑associated viruses to respond to tumor microenvironment cues and activate selectively within malignancies. The...

Nanovaccines for HCC: Preclinical platform primes anti‑tumor immunity

December 27, 2025

A team unveiled nanovaccine platforms designed to elicit immune responses against hepatocellular carcinoma (HCC). The nanoparticle formulations target tumor antigens and deliver immune‑stimulatory...

SpatialBench: New benchmark forces agents into real spatial‑biology workflows

December 27, 2025

SpatialBench was released as a suite of 146 verifiable spatial‑biology problems drawn from real workflows to evaluate agentic tools in biology. The benchmark spans five platforms (MERFISH, Seeker,...

Exosomal blueprint: Study maps how tumors prime lungs for metastasis

December 27, 2025

A landmark study traced exosomal signatures that orchestrate lung‑tropic metastasis, identifying molecular cargo and microenvironment changes that favor colonization. The research used multiomics...

Targeted protein degradation: Researchers map therapy effects across species and health

December 27, 2025

A new review and data synthesis examined the biological reach of targeted protein degradation (TPD) technologies, highlighting therapeutic promise and potential off‑target impacts across organs...

Lung cancer resistance: New combination therapies resensitize tumors

December 27, 2025

Researchers reported multiple preclinical strategies that overcome lung‑cancer drug resistance, including novel combinations that target epigenetic regulators and metabolic adaptations. Studies...