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Oncology drug discovery and targeted biology
Researchers have reported preclinical evidence that repurposed, clinically available drugs may improve outcomes in KMT2A::AFF1 positive infant B-cell precursor acute lymphoblastic leukemia...
Cancer immunotherapy response prediction
A new study reports spatial predictors that may identify which patients with microsatellite stable (MSS) metastatic colorectal cancer could benefit from chemo-immunotherapy. By mapping treatment...
Immunotherapy trial readouts at AACR
At AACR Annual Meeting 2026, investigators presented phase II INFINITY cohort results evaluating tremelimumab (Imjudo) plus durvalumab (Imfinzi) as an alternative to surgery for resectable gastric...
Platform and model systems for immunology in solid tumors
Researchers at VIB and VUB have introduced an orthotopic lung adenocarcinoma model paired with advanced single-cell sequencing to map the immune microenvironment with greater patient relevance....
Women’s health and biosimilars M&A
Sun Pharma announced an all-cash acquisition of Organon for $11.75 billion as it expands its portfolio in women’s health and biosimilars. The deal, structured at $14 per share, brings Organon’s...
Regulatory acceleration for psychedelic therapies
President Trump signed an executive order directing the FDA and other federal agencies to accelerate research and improve access to psychedelic drugs for serious mental illnesses. The order...
WHO prequalification for infant malaria therapy
The World Health Organization prequalified Coartem Baby, the first and only antimalarial for babies, developed by Novartis in partnership with Medicines for Malaria Venture (MMV). The...
Clinical validation of AI-enabled cardiovascular diagnostics
At SCAI 2026 Scientific Sessions & CAIC-ACCI Summit, the REACH trial presented performance data for a smart finger cuff algorithm aimed at detecting moderate-to-severe aortic stenosis. The report...
Cell and gene therapy engineering for cancer
A newly published study in Engineering describes live-cell glycocalyx engineering strategies to advance adoptive cell therapies targeting B lymphoma. The work addresses persistent barriers in...
Drug resistance mechanisms in oncology
Researchers have identified the AURKA/PHB2 signaling axis as a driver of acquired resistance to KRAS G12C inhibitors in non-small cell lung cancer. The study, published in 2026, reports that this...
Big Pharma M&A
Sun Pharma has agreed to acquire Organon for $11.75 billion in an all-cash deal valued at $14 per share, expanding its footprint in women’s health and biosimilars. The transaction follows...
WHO regulatory action for pediatric malaria
The World Health Organization has prequalified Coartem Baby, Novartis’ pediatric antimalarial combination developed with Medicines for Malaria Venture. The designation makes the product eligible...
Immunotherapy efficacy signal in microsatellite-high gastric/esophageal cancer
At AACR Annual Meeting 2026, researchers reported cohort 2 data from the single-arm INFINITY phase II trial testing tremelimumab plus durvalumab as an organ-preserving option in resectable...
Cell therapy platform engineering for B-cell lymphoma
A newly published study in Engineering lays out glycocalyx engineering strategies to improve adoptive cell therapies targeting B-cell lymphoma. The paper focuses on overcoming recurring...
New cancer biomarker model—spatial predictors for MSS mCRC
Researchers reported spatial predictors that delineate response to chemo-immunotherapy in microsatellite stable (MSS) metastatic colorectal cancer. The study’s core claim is that mapping features...
Oncology drug resistance mechanism in KRAS G12C therapy
A 2026 study described the acquired resistance pathway to KRAS G12C inhibitors in non-small cell lung cancer, identifying the AURKA/PHB2 signaling axis as a central driver. The authors reported...
Biosciences research tooling—AI microscopy in live cells
Engineers at the University of California San Diego introduced an AI-enhanced microscopy approach designed for crisp, real-time imaging inside live cells. The report says the system produces...
Policy and research funding shock—NSF National Science Board ousted
Multiple sources report that the Trump administration dismissed the entire National Science Board (NSB), which advises the president and Congress on the National Science Foundation (NSF). The...
Diagnostic AI in cardiology—smart finger cuff algorithm accuracy
A new smart finger cuff algorithm for detecting aortic stenosis demonstrated high accuracy for identifying moderate-to-severe disease in African American patients, according to results presented...
Discovery and platform—orthotopic lung model maps tumor location effects on immunity
Researchers at VIB and VUB unveiled an orthotopic lung adenocarcinoma model paired with advanced single-cell sequencing to map the immune microenvironment in lung tumors. The study focuses on how...