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AI powers City of Hope’s cancer care and research boost
City of Hope has launched HopeLLM, a generative AI platform integrating multiple AI models to streamline oncology workflows. The platform automates patient onboarding, facilitates clinical trial...
FDA leadership turnover amid regulatory shifts
The FDA is experiencing significant leadership changes impacting drug review and development. Acting CDER director Jacqueline Corrigan-Curay announced retirement following recent agency turnover,...
Nektar Therapeutics rebounds with positive phase 2b eczema data
Nektar Therapeutics reported promising Phase 2b results for rezpegaldesleukin, an IL-2 pathway agonist targeting atopic dermatitis. The drug demonstrated significant skin clearance improvements,...
Revolution Medicines secures $2 billion funding for RAS oncology pipeline
Revolution Medicines inked a flexible deal with Royalty Pharma for up to $2 billion to support global development and commercialization of its RAS(ON) inhibitor portfolio. The funding comprises...
Precision diagnostics advance with new AI and molecular tools
Multiple innovations are enhancing diagnostic precision in oncology and genomics. AI-driven tools like PromoterAI identify pathogenic promoter mutations contributing to genetic diseases. The...
Genetic and epigenetic breakthroughs impact disease understanding and therapy
Recent studies are elucidating molecular underpinnings of complex diseases. Research on SETD1B epigenetic regulation reveals its role in aggressive acute myeloid leukemia with FLT3-ITD mutation. A...
Cell and gene therapies show promising advancements in neurological and metabolic diseases
Innovative cell and gene therapy approaches demonstrate clinical potential. Vertex Pharmaceuticals' cell therapy zimislecel shows insulin independence in type 1 diabetes patients entering pivotal...
Environmental and agricultural innovations address sustainability challenges
Advances spanning climate resilience and agriculture are emerging. TUdi project introduces digital decision support tools to monitor soil health for regenerative agriculture globally. Cornell...
Novel therapeutic discoveries inaugurate new options in oncology and autoimmune diseases
Emerging therapies showcase advances in difficult diseases. Cytokine-induced killer cell therapy improves survival in colorectal cancer patients versus standard treatments. Hybrid combination...
Gene Therapy Extends Survival in Neurodegenerative Disease Model
A research team demonstrated a novel gene therapy using adeno-associated virus (AAV) to deliver RNA interference targeting the ataxin-2 gene, significantly extending survival and mitigating...
FDA Investigates Safety of Duchenne Gene Therapy After Patient Deaths
The FDA is investigating deaths related to liver failure following administration of Sarepta Therapeutics’ gene therapy for Duchenne muscular dystrophy. The regulator is assessing whether further...
AI Advances Semiconductor Growth with Autonomous Molecular Beam Epitaxy
The Paul Drude Institute and Bizmuth MBE Ltd. unveiled a collaborative project integrating large language models and multimodal AI technologies to autonomously control molecular beam epitaxy (MBE)...
City of Hope Launches Generative AI Platform to Personalize Cancer Care
City of Hope developed HopeLLM, a generative AI platform leveraging extensive oncology data to streamline clinical workflows and enhance patient personalization. The platform automates new patient...
Revolution Medicines Secures $2 Billion Royalty Deal to Fuel RAS(ON) Inhibitor Development
Revolution Medicines (Revmed) closed a landmark $2 billion flexible funding agreement with Royalty Pharma to support late-stage development and commercialization of its RAS(ON) multi-selective...
Nektar Therapeutics' Rezpeg Shows Promise in Atopic Dermatitis Phase 2b Trial
Nektar Therapeutics announced successful Phase 2b results for rezpegaldesleukin (rezpeg), an IL-2 pathway agonist, in moderate to severe atopic dermatitis. The drug hit primary and secondary...
Cidara Therapeutics Advances Long-Lasting Antiviral Against Influenza
Cidara Therapeutics reported positive mid-stage data for CD388, a drug-Fc conjugate antiviral providing season-long prophylaxis against influenza A and B viruses. Phase 2b results showed that a...
Deep Learning Improves Prediction of Walking Forces with Knee Alignment Data
Researchers demonstrated that incorporating detailed knee alignment parameters into deep learning models significantly enhances the accuracy of predicting ground reaction forces during walking....
Mitochondrial Base Editing Corrects Pathogenic Mutations in Human Cells
A team led by the University Medical Center Utrecht successfully applied mitochondrial base editing (mtBE) using a DddA-derived cytosine base editor (DdCBE) to precisely correct deleterious...
Advanced AI Tool Dissects Tumor Cellular Heterogeneity to Guide Cancer Treatment
An international consortium including the Garvan Institute developed AAnet, an artificial neural network leveraging single-cell gene expression data to resolve the diverse cellular populations...
FDA Probes Sarepta Duchenne Gene Therapy After Patient Deaths
The FDA is investigating Sarepta Therapeutics' gene therapy for Duchenne muscular dystrophy following patient deaths linked to liver failure. This regulatory scrutiny highlights concerns over...