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Vaxcyte’s Phase 3 pneumococcal vaccine hit raises competitive stakes
Vaxcyte reported that its experimental pneumococcal vaccine, VAX-31, met primary endpoints in the first of three Phase 3 trials, producing antibody effectiveness that matched Wall Street...
MRD blood monitoring takes aim at toxicity reduction in early breast cancer
A new global Phase 3 trial, AFT-70 NAVIGATE, will test whether ultrasensitive circulating-tumor DNA monitoring using Signatera MRD can safely guide therapy decisions in ER-positive/HER2-negative...
CSL and Alentis strike a rare mega-collaboration on rare fibrosis indications
CSL agreed to pay $355 million upfront and partner with Alentis Therapeutics through a collaboration valued at up to $1.6 billion to co-develop lixudebart for rare kidney and liver diseases. The...
Tarlatamab expands into real-world intracranial response for SCLC
Real-world analysis presented at the 2026 SNO/ASCO CNS Metastases conference suggests tarlatamab (DLL3/CD3) shows meaningful intracranial activity in small cell lung cancer patients with brain...
AI and biology join forces on in-cell RNA-to-DNA barcoding
Researchers introduced Detectrons, engineered biosensors that convert specific RNA sequences inside living cells into stable DNA barcodes readable by high-throughput sequencing. The system uses...
A proteomics map identifies subtypes and a new driver in cervical cancer
A large-scale proteomic analysis of 404 cervical cancer samples identified three molecular subtypes of squamous cell carcinoma with distinct prognoses and implicated CCM2 as a functional driver of...
Lung cancer biology reveals c-MET shapes immune suppression in spatial niches
A review in the Journal of Translational Medicine argues that c-MET signaling shapes lung cancer’s immune landscape in a spatially and metabolically constrained way, creating immunosuppressive...
CAR T tracking in patient organoids gets real-time AI monitoring
Researchers combined patient-derived pancreatic tumor organoids with a deep learning tracker, OrganoIDNet, to automatically monitor in real time how CD318-targeting CAR T cells destroy living...
Frailty, ICU biomarkers, and prediction tools sharpen clinical risk models
New evidence highlights how timing and physiology-based biomarkers can outperform single measurements in critical care and oncology-adjacent decision-making. In a multicenter ICU study of nearly...
Molecular glue drug discovery points to VAV1 degradation for blood cancers and autoimmunity
A Baylor College of Medicine-led team reported an AI-assisted approach to discover and optimize “molecular glue” compounds that degrade VAV1, an immune protein implicated in blood cancers and...
Immuno-oncology and CAR T monitoring in live tissue
Organoid-based imaging is moving into real-time tracking as researchers combine patient-derived pancreatic tumor organoids with deep learning to watch CAR T cells attack living tumor tissue. The...
Biopharma partnerships in kidney and liver fibrosis
CSL struck a co-development deal with Alentis Therapeutics for an anti-fibrosis program spanning kidney and liver indications, agreeing to a $355 million upfront payment and additional milestone...
Oncology real-world effectiveness for SCLC brain metastases
New real-world data suggest tarlatamab may produce clinically meaningful intracranial responses in small cell lung cancer patients with brain metastases, including groups that were...
Clinical trial signal for resistance exercise in breast-cancer lymphedema
A randomized controlled trial in China tested whether supervised resistance exercise can improve outcomes for breast cancer survivors living with lymphedema. After eight weeks, patients receiving...
AI-enabled early detection in gastroenterology endoscopy
An AI system designed to quantify what endoscopists actually see during upper GI procedures showed a strong link with higher early gastric cancer detection. In a landmark, multi-center trial...
Real-world cardiovascular AI for AF ablation response
A multicenter study evaluated an explainable machine learning model intended to predict which atrial fibrillation patients with heart failure are more likely to benefit from AF ablation. The model...
Computational drug discovery meets safety/feasibility for RNA-LNPs
Researchers proposed a pre-lab computational ranking framework to triage safer and more effective RNA-lipid nanoparticle (LNP) formulations before experimental testing. The University of Catania...
Genome sequencing outperforms standard testing for developmental disorders
A nationwide Belgian randomized trial reported that genome sequencing substantially improved diagnostic yield for developmental disorders compared with standard testing workflows. In the trial of...
COVID-19 vaccine effectiveness in dialysis patients
A nationwide South Korean study of more than 100,000 dialysis patients found strong protection from full COVID-19 vaccination against both SARS-CoV-2 infection and severe outcomes. The researchers...
Biotech industry: tariffs raise compliance and innovation uncertainty
Biotech experts warned that newly implemented pharmaceutical tariffs—up to 100% on patented drugs and ingredients—are adding costs and uncertainty while discouraging development and investment,...