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Precision host-factor genomics in primary CD4 T cells for HIV
Gladstone Institutes and UCSF reported a genome-wide CRISPR map of human genes that promote or restrict HIV infection in primary CD4+ T cells. Published in Cell, the work provides a host–virus...
Oncology immunotherapy signal in NEOPRISM-CRC bowel cancer
UCL and UCLH reported follow-up results from the NEOPRISM-CRC trial testing a short course of immunotherapy before surgery for a subset of bowel cancer patients. The update highlighted zero...
Proteomics platform partnership for precision oncology workflows
Nomic Bio partnered with Broad Clinical Labs to integrate Nomic’s Nomic Omni 1000 immunoassay platform into BCL’s omics offerings. The collaboration is intended to combine broad protein...
Spatial biology platform launch pressures competitors
10x Genomics launched Atera at AACR, positioning the in situ spatial biology platform for whole-transcriptome analysis at high throughput. The company said Atera can image multiple slides per run,...
Clinical pipeline update in alopecia areata with IL-2 biology
Nektar reported Phase II extension results for rezpegaldesleukin (rezpeg) in severe alopecia areata, describing additional hair regrowth in patients continuing treatment. The update focused on...
Regulatory-grade evidence for MRD sequencing in TRACERx
Ultima Genomics reported TRACERx trial data supporting a whole-genome ctDNA approach using duplex sequencing without bespoke tumor-informed assays. At AACR, Jonathan Wan of UCL and the Francis...
Therapeutic strategy in ulcerative colitis via JAK1–NLRP3 pathway
Researchers reported in Nature Communications that JAK1 inhibitors reduce ulcerative colitis activity through suppression of the NLRP3–IL-1β signaling axis. The mechanistic work links a widely...
Lilly in vivo genetic medicines acquisition strategy expands
Industry reporting detailed how Lilly’s Kelonia acquisition fits a broader “in vivo” genetic medicines strategy, building on prior deals to expand the company’s cell therapy and genetic medicine...
Eli Lilly in vivo CAR-T expansion via Kelonia acquisition
Eli Lilly agreed to acquire Kelonia Therapeutics in a deal worth up to $7 billion, expanding the company’s in vivo CAR-T ambitions for multiple myeloma and beyond. Lilly will pay $3.25 billion...
Updated clinical signal in alopecia areata extension study
Nektar Therapeutics disclosed additional hair-regrowth data from a 16-week extension of its Phase IIb REZOLVE-AA study of rezpegaldesleukin (rezpeg), highlighting deeper responses among late...
Whole-genome ctDNA MRD readout streamlines risk stratification in lung cancer
At AACR, researchers reported clinical value for tumor-informed MRD detection using whole-genome sequencing paired with Ultima Genomics duplex sequencing in TRACERx. The approach, using paired...
NEOPRISM-CRC bowel cancer trial reports zero relapses after short immunotherapy lead-in
A clinical trial led by University College London (UCL) and UCL Hospitals (UCLH) reported follow-up results from NEOPRISM-CRC, testing a short course of immunotherapy prior to surgery for a subset...
In vitro gene-editing map pinpoints HIV host factors in primary CD4+ T cells
Gladstone Institutes and UCSF published a genome-wide CRISPR screen mapping human genes that either promote or restrict HIV infection in primary CD4+ T cells. Using optimized infection conditions...
CRISPR-based protein activity modeling aims to improve therapeutics design
Researchers developed an AI model to predict how proteins behave by reading and learning patterns from protein pairs, targeting better representation of protein–protein interactions. The platform...
10x Genomics Atera pushes in situ whole-transcriptome spatial biology
10x Genomics launched Atera, an in situ spatial biology platform aimed at whole-transcriptome profiling with single-cell resolution and higher throughput. The company said the instrument will...
Foundation Medicine expands MRD portfolio via Roche deal for SAGA Diagnostics
Roche’s affiliate Foundation Medicine agreed to acquire SAGA Diagnostics in a transaction valued at up to $595 million, designed to broaden Foundation’s MRD diagnostics portfolio. The deal adds...
New FDA review approach for eliminating unnecessary animal studies
The FDA published a perspective on eliminating unnecessary animal studies, pushing developers toward more scientifically justified nonclinical packages and away from redundant preclinical work....
Nomic Bio and Broad Clinical Labs add quantitative proteomics to multimodal risk models
Nomic Bio partnered with Broad Clinical Labs (BCL) to integrate Nomic’s Nomic Omni 1000 immunoassay platform into BCL’s omics offerings. The collaboration is intended to incorporate quantitative...
Lilly to scale in vivo CAR-T with Kelonia buyout
Eli Lilly announced it will acquire Kelonia Therapeutics for up to $7 billion, paying $3.25 billion upfront with additional milestone payments tied to clinical, regulatory and commercial outcomes....
iGPS Kelonia purchase reframes Lilly’s in-vivo pipeline bets
Further coverage of the acquisition highlights how Kelonia’s in vivo gene placement system (iGPS) adds another clinical-stage asset to Lilly’s genetic medicines roadmap. The buyer’s broader...