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Iambic Therapeutics launches with $150M IPO to build an AI-driven oncology pipeline
Iambic Therapeutics, an Nvidia-backed AI drug-discovery company, priced a $150 million initial public offering and is set to begin trading this week. The cancer-focused biotech sold 9.38 million...
Oxford-based OMass Therapeutics raises $310M to challenge leading genetic adrenal disorder players
OMass Therapeutics, an Oxford-based developer targeting genetic adrenal disorders, raised $310 million in a private financing. The company said it plans to pursue programs in endocrinology, taking...
Pfizer and Enodia strike licensing collaboration to develop Sec61 inhibitors
Pfizer signed a research collaboration and licensing agreement with Enodia Therapeutics that gives the pharma a stake in Sec61 inhibition programs. Under the deal, Enodia will run discovery work...
EMA locks in EU-level trial advice pilot as permanent option for sponsors
The European Medicines Agency will make an EU-level trial advice pilot a permanent option for drug sponsors. In a regulatory update, EMA confirmed that sponsors running studies in the European...
Triple therapy plus hepatic arterial infusion roughly doubles survival in advanced liver cancer with portal vein tumor thrombosis
A prospective controlled study in BMC Medicine reported that adding hepatic arterial infusion chemotherapy to lenvatinib and a PD-1 inhibitor roughly doubled median overall survival in advanced...
Arrowhead’s ARO-MAPT shows early human tau knockdown with brain-shuttle target engagement
Arrowhead Pharmaceuticals reported early clinical results suggesting its brain-targeting RNA interference medicine can reduce tau protein levels in humans. In a trial in healthy volunteers, the...
Verastem steps up pancreatic cancer push with VS-7375 data, CEO departure, and $250M raise
Verastem Oncology reported new data across multiple tumor types for its KRAS-mutant program VS-7375 and simultaneously announced a leadership change and funding. The company said its experimental...
New rule linking drug penetration to shortened tuberculosis regimens aims to explain Phase 3 failures
Researchers led by Radojka M. Savic and Véronique Dartois built a validated translational tool connecting how well anti-tuberculosis drugs penetrate lung lesions to the chance of success in...
Healthleap raises $38M to expand EHR-based AI screening for overlooked inpatient conditions
Healthleap secured $38 million to scale its clinical AI platform that runs inside electronic health records. The company’s screening system targets conditions that may otherwise go undiagnosed in...
Tiny genetic switches: maternally driven tauopathy and SRSF1 rejuvenation highlight splicing-linked neurobiology
Two neuroscience-facing studies underscored how RNA regulation can reshape neurodegeneration pathways. A transcriptomic aging-screen identified SRSF1 as a conserved regulator of aging, with...
IPO & capital raises in AI-driven oncology
Iambic Therapeutics priced a $150 million IPO, starting trading Thursday after selling 9.38 million shares at $16 each. The cancer-focused company positions its AI-driven platform as a way to...
Adverse-event research after transfusions in thalassemia
A new study suggests a hidden immune gene variant may help explain dangerous blood transfusion reactions in transfusion-dependent thalassemia patients. By linking immunologic recognition risk to...
Transplant science milestone: cryopreserved pig kidneys recover after long storage
Scientists reported that pig kidneys cooled to about -150°C and stored for months can be rewarmed and function again, with urine production after transplantation into pigs. The preprint describes...
Regulatory shift in the EU clinical advice process
The European Medicines Agency (EMA) confirmed it will turn an EU-level clinical trial advice pilot into a permanent option for sponsors. That change means companies can continue seeking harmonized...
Immunotherapy–chemoradiation sequencing in nasopharyngeal cancer
A prospective Chinese study reported striking responses in locally advanced nasopharyngeal carcinoma when camrelizumab was added to induction chemotherapy before concurrent chemoradiotherapy....
Mechanism-linked therapy target in lung cancer cuproptosis
Researchers mapped a USP11–IGF2BP2–ATOX1 molecular axis that shields non-small cell lung cancer cells from copper-driven cuproptosis. By identifying the pathway that preserves cell survival under...
Oncology clinical trial signal: triple therapy extends survival in liver cancer with portal vein clots
A prospective controlled study reported that adding hepatic arterial infusion chemotherapy to lenvatinib plus a PD-1 inhibitor roughly doubled median overall survival in advanced liver cancer...
Drug delivery & translational manufacturing: Arrowhead brain shuttle target engagement
Arrowhead reported early human target-engagement support for a brain-shuttling delivery approach using systemic RNAi dosing in healthy volunteers. The company framed the milestone as progress on...
Tech-to-clinic: pharmacists embedded in primary care for opioid use disorder
A multi-site clinical trial found pharmacist integration into primary care teams for opioid use disorder was feasible and acceptable, with modest improvements in treatment retention and adherence....
Kidney therapeutics: potassium binder enables full RAAS inhibitor dosing in CKD with heart failure
A randomized double-blind trial reported that sodium zirconium cyclosilicate helped more chronic kidney disease patients with heart failure reach target doses of life-prolonging RAAS inhibitors...