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Exact Sciences and Freenome Team on Colorectal Cancer Screening
Exact Sciences is acquiring U.S. rights to Freenome’s colorectal cancer liquid biopsy test with a $75 million upfront payment, positioning to challenge Guardant Health in the expanding early...
AI Advances Enhance Emergency Care and Medical Imaging
Research teams have unveiled AI-driven models that significantly improve hospital admission predictions from emergency departments, aiming to reduce overcrowding and enhance patient care...
Microbial Links to Neurological Disorders Revealed
Recent studies have elucidated how gut and microbial flora influence neurodegenerative and chronic pain conditions. Research implicates specific Desulfovibrio bacterial strains in...
Boston Life Sciences Real Estate Market Faces Record Vacancies
Greater Boston’s life sciences real estate sector confronts unprecedented vacancy rates, reaching 29.7% including subleases, fueled by speculative construction exceeding tenant demand amid a...
Emerging Therapies and Biotechnology Innovations
Several breakthrough biological and synthetic technologies are advancing therapeutic frontiers. This includes a multivalent mRNA vaccine offering protection against monkeypox in animal models;...
Regulatory and Market Challenges in Pharma Access and Pricing
Rising formulary restrictions and patient out-of-pocket costs exacerbate prescription abandonment, despite large pharma investments in copay assistance that remain under-recognized by patients....
Novartis Claims Twin Phase 3 Wins in Sjögren's Syndrome Trials
Novartis announced successful outcomes from two phase 3 trials of ianalumab, a B-cell-depleting antibody targeting BAFF-R, in treating systemic autoimmune Sjögren's syndrome. The Neptunus 1 and 2...
Vinay Prasad Returns to FDA Amid Controversy
Vinay Prasad has unexpectedly rejoined the FDA to lead the Center for Biologics Evaluation and Research (CBER), weeks after stepping down amid tensions surrounding gene therapy regulation and...
Microbiome’s Role in Fibromyalgia Pain Mechanisms
New research using germ-free mouse models demonstrates a causal relationship between altered gut microbiota and fibromyalgia-like chronic pain. Fecal microbiome transplants from fibromyalgia...
Sarepta Addresses Patient Deaths in Elevidys Gene Therapy Reports
Sarepta Therapeutics clarified that two patient deaths associated with their Duchenne muscular dystrophy gene therapy Elevidys, reported in FDA adverse event databases, were unrelated to...
Regulatory Hurdles Reshape Pharma Marketing and Patient Access
The pharmaceutical industry faces growing challenges in converting direct-to-consumer awareness campaigns into actual medication adherence due to escalating payer restrictions and high...
New AI Model Advances Stroke Imaging Precision
A novel deep learning model named DeepISLES, validated clinically, promises to significantly improve ischemic stroke lesion segmentation. By reliably delineating stroke-affected regions, this AI...
Mitochondrial Metabolism Drives Colorectal Cancer Drug Resistance
Emerging evidence highlights mitochondrial metabolic reprogramming as a key mechanism enabling colorectal cancer cells to resist chemotherapy and targeted therapies. Tumors adapt through...
Omega Fatty Acid Profiling Breakthrough Benefits Disease Research
Researchers have developed an innovative technique enabling the comprehensive characterization of omega fatty acids, overcoming previous biochemical challenges. This advancement facilitates...
Neuroprosthetics Enable Gut Motility and Metabolism Control
A cutting-edge gastrointestinal neuroprosthesis interfacing with the enteric nervous system has been developed to modulate gut motility and metabolic functions through precise neuromodulation....
Al–Salen Catalyst Advances Enantioselective Photocyclization Chemistry
Scientists have introduced an aluminum-salen (Al–salen) catalyst that enables enantioselective photocyclization via energy transfer mechanisms. This pioneering work grants unprecedented...
Novartis Wins Phase 3 Trials in Sjögren's Syndrome – Regulatory Plans Set
Novartis announced successful results from two phase 3 trials of ianalumab, targeting BAFF-R in patients with Sjögren's syndrome. Both Neptunus 1 and 2 studies met their primary endpoints, showing...
Sarepta Addresses Patient Deaths in Elevidys Reports – FDA Data Reviewed
Sarepta Therapeutics clarified that two patient deaths reported in the FDA Adverse Event Reporting System (FAERS) related to Elevidys, its gene therapy for Duchenne muscular dystrophy, were...
Vinay Prasad Returns to Lead FDA’s CBER Amid Controversy
In an unexpected development, Dr. Vinay Prasad has resumed leadership of the FDA’s Center for Biologics Evaluation and Research (CBER) shortly after stepping down. The Department of Health and...
Microbiome Link to Fibromyalgia Evidence Emerges from Mouse Studies
New research using germ-free mice demonstrates a causative role of gut microbiota in fibromyalgia-like chronic pain. Transferring fecal samples from fibromyalgia patients induced systemic pain...